MARK3 and PKP2

Number of citations of the paper that reports this interaction (PubMedID 12941695)
36

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)
HPRD (in vivo, in vitro)

		MARK3	PKP2
Description		microtubule affinity regulating kinase 3	plakophilin 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Cell Projection Extracellular Exosome	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Intercalated Disc Membrane Cell Junction Desmosome Cell Tip Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity	DNA Binding Protein Kinase C Binding Protein Binding Sodium Channel Regulator Activity Intermediate Filament Binding Transmembrane Transporter Binding Alpha-catenin Binding Cadherin Binding Molecular Adaptor Activity Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
	Biological Process	Microtubule Cytoskeleton Organization Protein Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus	Desmosome Assembly Desmosome Organization Cell Adhesion Cell-cell Signaling Heart Development Positive Regulation Of Sodium Ion Transport Regulation Of Cell-substrate Adhesion Intermediate Filament Bundle Assembly Maintenance Of Animal Organ Identity Ventricular Cardiac Muscle Tissue Morphogenesis Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Maintenance Of Protein Localization At Cell Tip Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Transcriptional and post-translational regulation of MITF-M expression and activity	Keratinization Formation of the cornified envelope
Drugs		Fostamatinib
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778 33020668) Cutaneous melanoma or hair colour ( 32341527) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Optic disc size ( 31809533) PR interval ( 32439900) Systolic blood pressure ( 30578418 30224653) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)	Atrial fibrillation ( 29892015 30061737) Blood protein levels ( 30072576) Body mass index (change over time) in lung cancer ( 28044437) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965 32201043) Periodontal disease related phenotype (PCT5) ( 26962152) Prevalent atrial fibrillation ( 28416818)
Interacting Genes		28 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CHGB CLASP1 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAZ	48 interacting genes: ACTN3 AKAP9 ARMC8 BAG4 CARD9 CASK CCDC120 CCDC125 CCHCR1 CTBP1 CTNNB1 DMRTB1 DSC1 DSC2 DSG1 DSG2 DSP EIF4ENIF1 EXOSC8 FHL3 GOLGA2 GRIPAP1 GTF2IRD1 HOOK2 HSPB2 JUP KLC4 KRT18 KRT31 KRT5 MAGOHB MARK3 MTUS2 NCKIPSD NDEL1 PIBF1 PLEKHG4 POLR3A RABEP1 RBM5 RBPMS ROPN1 SMAD9 SPTA1 TEKT4 VHL VIM YWHAG
Entrez ID		4140	5318
HPRD ID		04058	04177
Ensembl ID		ENSG00000075413	ENSG00000057294
Uniprot IDs		A0A7I2V2E3 A0A7I2V2N8 A0A7I2V3B9 A0A7I2V5G3 A0A7I2V639 A0A7I2YQF7 H0YNV4 P27448 Q86U11	A0A8V8TPU9 A0AAQ5BGY2 Q99959
PDB IDs		2QNJ 3FE3 7P1L 8UOH 8UOI 8UOJ 8UOK 8UOL	3TT9
Enriched GO Terms of Interacting Partners?		Protein Kinase C Inhibitor Activity Phosphoserine Residue Binding Main Axon Regulation Of Microtubule Polymerization Or Depolymerization Protein Sequestering Activity Negative Regulation Of Microtubule Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Phosphorylation Positive Regulation Of Intracellular Transport Dystroglycan Binding Protein Kinase Binding Tubulin Binding Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule Polymerization Phototransduction, Visible Light Regulation Of Cell Differentiation Microtubule	Desmosome Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Cytoskeleton Organization Cornified Envelope Regulation Of Cardiac Muscle Cell Action Potential Cytoplasm Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Regulation Of Heart Rate By Cardiac Conduction Intercalated Disc Cardiac Conduction Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Intermediate Filament Cytoskeleton Regulation Of Action Potential Cytosol Regulation Of Cardiac Muscle Cell Contraction Cell Junction Scaffold Protein Binding Heterotypic Cell-cell Adhesion Microtubule Organizing Center Regulation Of Striated Muscle Contraction Structural Constituent Of Cytoskeleton Regulation Of Heart Rate Cell-cell Junction Organization Organelle Organization Catenin-TCF7L2 Complex Cell-cell Junction Homotypic Cell-cell Adhesion Intracellular Protein Localization Protein Binding Intermediate Filament Organization Cellular Response To Indole-3-methanol Regulation Of Muscle System Process Nucleus Regulation Of Cardiac Muscle Contraction Microtubule Nucleation Cell-cell Adhesion Microtubule-based Process Response To Indole-3-methanol Regulation Of Muscle Contraction Anchoring Junction Fascia Adherens Adherens Junction Focal Adhesion Protein-DNA Complex Regulation Of Heart Contraction
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