MAPT and CASP8

Number of citations of the paper that reports this interaction (PubMedID 12888622)
40

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro, in vivo)

		MAPT	CASP8
Description		microtubule associated protein tau	caspase 8
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Growth Cone Axolemma Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Somatodendritic Compartment Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Cell Body Main Axon Membrane Raft Tubulin Complex Glial Cell Projection Neurofibrillary Tangle Axon Cytoplasm	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Plasma Membrane Lamellipodium Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Cell Projection Cell Body Ripoptosome
	Molecular Function	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Actin Binding Protein Binding Microtubule Binding Tubulin Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Apolipoprotein Binding Dynactin Binding Phosphatidylinositol Binding Identical Protein Binding Sequence-specific DNA Binding Protein-folding Chaperone Binding Protein Phosphatase 2A Binding Hsp90 Protein Binding Lipoprotein Particle Binding Histone-dependent DNA Binding Microtubule Lateral Binding Phosphatidylinositol Bisphosphate Binding	Cysteine-type Endopeptidase Activity Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Scaffold Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Microglial Cell Activation DNA Damage Response Cell-cell Signaling Synapse Assembly Learning Or Memory Memory Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrial Membrane Potential RRNA Metabolic Process Axonal Transport Of Mitochondrion Central Nervous System Neuron Development Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Neuron Projection Development Positive Regulation Of Superoxide Anion Generation Regulation Of Chromosome Organization Stress Granule Assembly Cellular Response To Heat Cellular Response To Reactive Oxygen Species Positive Regulation Of Axon Extension Microtubule Polymerization Astrocyte Activation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Generation Of Neurons Synapse Organization Regulation Of Calcium-mediated Signaling Protein Polymerization Protein Homooligomerization Axon Development Regulation Of Microtubule Cytoskeleton Organization Plus-end-directed Organelle Transport Along Microtubule Regulation Of Mitochondrial Fission Negative Regulation Of Mitochondrial Fission Supramolecular Fiber Organization Axonal Transport Regulation Of Cellular Response To Heat Regulation Of Long-term Synaptic Depression Positive Regulation Of Protein Localization To Synapse Neurofibrillary Tangle Assembly Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Protein Localization Negative Regulation Of Tubulin Deacetylation Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Autophagosome Assembly Angiogenesis Regulation Of Cytokine Production Regulation Of Immune System Process Proteolysis Apoptotic Process Heart Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Processing Natural Killer Cell Activation Cell Differentiation Macrophage Differentiation Positive Regulation Of Cell Migration Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Response To Tumor Necrosis Factor TRAIL-activated Apoptotic Signaling Pathway T Cell Activation B Cell Activation Regulation Of Apoptotic Process Chordate Embryonic Development Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Regulation Of Innate Immune Response Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Animal Organ Development Proteolysis Involved In Protein Catabolic Process Protein Maturation Negative Regulation Of Necroptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Pyroptotic Inflammatory Response Cellular Response To Mechanical Stimulus Response To Anesthetic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Self Proteolysis Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis
Pathways		Caspase-mediated cleavage of cytoskeletal proteins	Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Microbial modulation of RIPK1-mediated regulated necrosis Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling
Drugs		Lansoprazole Astemizole Paclitaxel Docetaxel Flortaucipir F-18	Trichostatin A AN-9 Bryostatin 1 Bardoxolone Oleandrin
Diseases		Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease	Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		A body shape index ( 34021172) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30336701 33861876) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease in APOE e4- carriers ( 25778476) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Atrial fibrillation ( 29892015) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive performance (processing speed) ( 31598132) Corticobasal degeneration ( 26077951) Experiencing mood swings ( 29500382) Feeling hurt ( 29500382) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) HDL cholesterol levels ( 32203549) Head circumference (infant) ( 22504419) Headache ( 29397368) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156 31710517) Immature fraction of reticulocytes ( 32888494) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Left–right brain asymmetry ( 33723403) Lumbar spine bone mineral density ( 22504420) Male-pattern baldness ( 29146897 28196072) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (anilides) ( 31015401) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Neuroticism ( 29255261) Neutrophil percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Osteoarthrosis (time to event) ( 32589924) Parkinson's disease ( 31660654 20070850 20711177 21044948 21292315 34064523 21738487 22438815 24511991 24842889 25064009 28892059 19915575) Plasma t-tau levels ( 28100725) Pork consumption ( 32066663) Primary biliary cirrhosis ( 22961000) Progressive supranuclear palsy ( 31059154 30089514 21685912) QRS complex (12-leadsum) ( 27659466) Reaction time ( 29844566) Red blood cell count ( 32888494) Refractive error ( 32231278) Retinal detachment or retinal break ( 31816047) Serum alkaline phosphatase levels ( 33547301) Smoking initiation ( 33082346) Subcortical brain region volumes ( 25607358) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter integrity (mean diffusivity) ( 32358547)	Basal cell carcinoma ( 33549134 25855136 28177523) Breast cancer ( 29059683) Chronic lymphocytic leukemia ( 23770605 26956414 28165464) Cutaneous malignant melanoma ( 32341527) Esophageal squamous cell carcinoma ( 25129146) Lymphocyte count ( 27863252) Melanoma ( 28212542 21983787) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Nevus count or cutaneous melanoma ( 30429480 32341527) Non-small cell lung cancer ( 31326317) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Rheumatoid arthritis ( 30423114 24390342) Spleen volume ( 34128465) White blood cell count ( 32888494)
Interacting Genes		127 interacting genes: AATF ABL1 ACTA1 ACTB ACTG1 AKT1 AMPH APOE ARHGEF40 BAG1 BRSK1 BRSK2 CALM1 CAMK2A CAPN1 CASP1 CASP2 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CHEK1 CHEK2 CREBBP CSNK2A1 CTSD DUSP1 DYRK1A DYRK2 EGFR EP300 F2 FKBP1A FYN GSK3A GSK3B HDAC6 HNRNPC HOOK3 HSPA8 HTRA1 LCK LGMN LRRK2 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MARCHF7 MARK1 MARK3 MARK4 MASP1 MDM2 MELK NPEPPS OGT OTUB1 PACSIN1 PDIA2 PEG10 PHKG1 PIK3R1 PIN1 PKN1 PLCG1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP2R5A PPP5C PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCZ PSEN1 PTGES3 PTK2B PTPA PTPN11 PWP2 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SIK1 SNCA SPTB SQSTM1 SRC SRPK1 SRPK2 STAU1 STUB1 STXBP1 SYK TRAF6 TRIM11 TTBK1 TUBA1B TUBA4A TUBB TUBB3 UBB UBE2D2 UBE2D3 UBE2W USP9Y YWHAB YWHAZ	133 interacting genes: AGR3 ANGPTL4 AP1M1 APAF1 APP AR ATAD2 ATG4D ATP1A3 BAP1 BCAP31 BCL2 BCL2L1 BCL2L10 BEX1 BFAR BID BIRC6 BLID BRD1 CASC3 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CCNL1 CDH1 CDH13 CDK11B CDKN1B CFLAR CHD3 CHUK CNBP COPS6 CRADD CTNNB1 DEDD DEDD2 EDA2R EIF2AK2 EPSTI1 ERRFI1 FADD FAF1 FAS FYN GLCE GMEB1 GREB1 GRIA1 GZMB HBP1 HDAC7 HECTD3 HIP1 IKBKB IKBKG IL13RA2 IL24 ILK KLK5 KLK9 KRT18 LYPD3 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 NSD3 OGT PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PIK3C3 PLA2G4B PLEC PLIN4 PRDM14 PRDX6 PRKCI PRKCZ PRKN PRSS50 PSEN1 PSEN2 PSMC3IP QDPR RALBP1 RB1 RIPK1 RIPK2 RNF31 RYBP S100A14 SCGB2A2 SERPINB5 SNRPD3 SOX2 SRC SRF ST14 STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 UBC UMPS USO1 VIM VPS45 YBX1 ZNF707
Entrez ID		4137	841
HPRD ID		01142	03459
Ensembl ID		ENSG00000186868	ENSG00000064012
Uniprot IDs		A0A7I2PJZ2 A0A7I2PLE3 B3KTM0 P10636	A0A8Q3SID9 Q14790
PDB IDs		1I8H 2MZ7 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3 5K7N 5MO3 5MP1 5MP3 5MP5 5N5A 5N5B 5NVB 5O3L 5O3O 5O3T 5V5B 5V5C 5ZIA 5ZV3 6BB4 6CVJ 6CVN 6DC8 6DC9 6DCA 6FBW 6FI5 6GK7 6GK8 6GX5 6H06 6HRE 6HRF 6LRA 6N4P 6NK4 6NWP 6NWQ 6ODG 6PXR 6QJH 6QJM 6QJP 6QJQ 6TJO 6TJX 6VH7 6VHA 6VHL 6VI3 6XLI 7EYC 7KQK 7MKF 7MKG 7MKH 7NRQ 7NRS 7NRT 7NRV 7NRX 7P65 7P66 7P67 7P68 7P6A 7P6B 7P6C 7P6D 7P6E 7PQC 7PQP 7QJV 7QJW 7QJX 7QJY 7QJZ 7QK1 7QK2 7QK3 7QK5 7QK6 7QKF 7QKG 7QKH 7QKI 7QKJ 7QKK 7QKL 7QKM 7QKU 7QKV 7QKW 7QKX 7QKY 7QKZ 7QL0 7QL1 7QL2 7QL3 7QL4 7R4T 7R5H 7SP1 7U0Z 7UPE 7UPF 7UPG 7YMN 7YPG 8AZU 8BGS 8BGV 8BYN 8CAQ 8CAX 8FNZ 8FUG 8FYU 8G54 8G55 8G58 8GCK 8KDX 8OH2 8OHI 8OHP 8OI0 8OP0 8OPI 8ORE 8ORF 8ORG 8OT6 8OT9 8OTC 8OTG 8OTH 8OTI 8OTJ 8P34 8PII 8PPO 8Q27 8Q2J 8Q2K 8Q2L 8Q7F 8Q7L 8Q7M 8Q7P 8Q7T 8Q88 8Q8C 8Q8D 8Q8E 8Q8F 8Q8L 8Q8M 8Q8R 8Q8S 8Q8U 8Q8V 8Q8W 8Q8X 8Q8Y 8Q8Z 8Q92 8Q97 8Q98 8Q99 8Q9A 8Q9B 8Q9C 8Q9D 8Q9E 8Q9F 8Q9G 8Q9H 8Q9I 8Q9J 8Q9K 8Q9L 8Q9M 8Q9O 8QCP 8QCR 8QDV 8QJJ 8R3T 8SEH 8SEI 8TTL 8TTN 8UQ7 8V1N 8WCP 8ZWL 8ZWM 8ZX6 9B4L 9B4M 9B4N 9B4O 9BBL 9BBM 9BXI 9BXO 9BXQ 9BXR 9CGX 9CGZ 9CZI 9CZL 9EO7 9EO9 9EOE 9EOG 9EOH 9ERM 9ERN 9ERO 9G13 9GG0 9GG1 9GG6 9H5G 9H5J 9HBB 9MR8	1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7 4PRZ 4PS1 4ZBW 5H31 5H33 5JQE 5L08 6AGW 6PX9 7DEE 7LVJ 7LVM 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Kinase Activity Protein Modification Process Protein Metabolic Process Tau Protein Binding Intracellular Signal Transduction Protein Phosphorylation Phosphorylation Cytoplasm ATP Binding Cytosol Transferase Activity Nucleotide Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Macromolecule Metabolic Process Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Stress Response To Stress Regulation Of Signaling Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signaling Cassette Negative Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Nucleus Positive Regulation Of Cell Communication Regulation Of Protein-containing Complex Assembly Programmed Cell Death Cell Death Apoptotic Process Tau-protein Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Metabolic Process MAP Kinase Activity Regulation Of Immune System Process Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission	Programmed Cell Death Cell Death Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Extrinsic Apoptotic Signaling Pathway Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Response To Stress Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Cytosol Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Signaling Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Neuron Apoptotic Process Cytoplasm Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Oxygen-containing Compound Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Cysteine-type Endopeptidase Activity Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Programmed Necrotic Cell Death
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