MAPT and SRPK2

Number of citations: 45 (PubMedID 28826672)
Data Source: BioGRID (enzymatic study)

		MAPT	SRPK2
Name		microtubule associated protein tau	SRSF protein kinase 2
Structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Growth Cone Axolemma Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Somatodendritic Compartment Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Cell Body Main Axon Membrane Raft Tubulin Complex Glial Cell Projection Neurofibrillary Tangle Axon Cytoplasm	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nuclear Speck Presynapse
	Molecular Function	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Actin Binding Protein Binding Microtubule Binding Tubulin Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Apolipoprotein Binding Dynactin Binding Phosphatidylinositol Binding Identical Protein Binding Sequence-specific DNA Binding Protein-folding Chaperone Binding Protein Phosphatase 2A Binding Hsp90 Protein Binding Lipoprotein Particle Binding Histone-dependent DNA Binding Microtubule Lateral Binding Phosphatidylinositol Bisphosphate Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity 14-3-3 Protein Binding Protein Serine Kinase Activity
	Biological Process	Microtubule Cytoskeleton Organization Microglial Cell Activation DNA Damage Response Cell-cell Signaling Synapse Assembly Learning Or Memory Memory Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrial Membrane Potential RRNA Metabolic Process Axonal Transport Of Mitochondrion Central Nervous System Neuron Development Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Neuron Projection Development Positive Regulation Of Superoxide Anion Generation Regulation Of Chromosome Organization Stress Granule Assembly Cellular Response To Heat Cellular Response To Reactive Oxygen Species Positive Regulation Of Axon Extension Microtubule Polymerization Astrocyte Activation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Generation Of Neurons Synapse Organization Regulation Of Calcium-mediated Signaling Protein Polymerization Protein Homooligomerization Axon Development Regulation Of Microtubule Cytoskeleton Organization Plus-end-directed Organelle Transport Along Microtubule Regulation Of Mitochondrial Fission Negative Regulation Of Mitochondrial Fission Supramolecular Fiber Organization Axonal Transport Regulation Of Cellular Response To Heat Regulation Of Long-term Synaptic Depression Positive Regulation Of Protein Localization To Synapse Neurofibrillary Tangle Assembly Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Protein Localization Negative Regulation Of Tubulin Deacetylation Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Spliceosomal Complex Assembly Angiogenesis MRNA Processing Protein Phosphorylation Positive Regulation Of Cell Population Proliferation RNA Splicing Regulation Of Gene Expression Positive Regulation Of Gene Expression Peptidyl-serine Phosphorylation Cell Differentiation Nuclear Speck Organization Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Viral Genome Replication Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Cell Cycle Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing R-loop Processing
Pathways		Caspase-mediated cleavage of cytoskeletal proteins	Maturation of nucleoprotein
Drugs		Lansoprazole Astemizole Paclitaxel Docetaxel Flortaucipir F-18	Adenine Purvalanol Phosphoaminophosphonic Acid-Adenylate Ester
Diseases		Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease	None
GWAS		A body shape index ( 34021172 ) Alcohol consumption ( 31358974 ) Alcohol consumption (drinks per week) ( 30643258 ) Alcohol use disorder (consumption score) ( 30336701 33861876 ) Alcohol use disorder (total score) ( 30336701 ) Alzheimer's disease ( 31473137 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 ) Atrial fibrillation ( 29892015 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive ability ( 29186694 ) Cognitive ability (MTAG) ( 29186694 ) Cognitive performance (processing speed) ( 31598132 ) Corticobasal degeneration ( 26077951 ) Experiencing mood swings ( 29500382 ) Feeling hurt ( 29500382 ) General cognitive ability ( 29844566 ) General factor of neuroticism ( 30867560 ) Glaucoma (primary open-angle) ( 33627673 ) Handedness (Left-handed vs. non-left-handed) ( 31504236 ) Handedness (left-handed vs. right-handed) ( 31504236 ) Handedness (non-right-handed vs right-handed) ( 31504236 ) HDL cholesterol levels ( 32203549 ) Head circumference (infant) ( 22504419 ) Headache ( 29397368 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Household income ( 31844048 ) Household income (MTAG) ( 31844048 ) Idiopathic pulmonary fibrosis ( 24429156 31710517 ) Immature fraction of reticulocytes ( 32888494 ) Interstitial lung disease ( 23583980 ) Intracranial volume ( 22504418 ) Left–right brain asymmetry ( 33723403 ) Lumbar spine bone mineral density ( 22504420 ) Male-pattern baldness ( 29146897 28196072 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (anilides) ( 31015401 ) Mood instability ( 31168069 ) Multiple system atrophy ( 27629089 ) Neuroticism ( 29255261 ) Neutrophil percentage of white cells ( 32888494 ) Oily fish consumption ( 32066663 ) Osteoarthrosis (time to event) ( 32589924 ) Parkinson's disease ( 31660654 20070850 20711177 21044948 21292315 34064523 21738487 22438815 24511991 24842889 25064009 28892059 19915575 ) Plasma t-tau levels ( 28100725 ) Pork consumption ( 32066663 ) Primary biliary cirrhosis ( 22961000 ) Progressive supranuclear palsy ( 31059154 30089514 21685912 ) QRS complex (12-leadsum) ( 27659466 ) Reaction time ( 29844566 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Retinal detachment or retinal break ( 31816047 ) Serum alkaline phosphatase levels ( 33547301 ) Smoking initiation ( 33082346 ) Subcortical brain region volumes ( 25607358 ) Type 1 diabetes ( 34127860 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White matter integrity (mean diffusivity) ( 32358547 )	Advanced age-related macular degeneration ( 26691988 ) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder ( 30804558 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 34002096 31043756 ) General cognitive ability ( 29844566 ) Myopia (pathological) ( 23049088 ) Regular attendance at a religious group ( 29970889 ) Schizophrenia ( 29483656 30285260 28991256 25056061 ) Uterine fibroid size (maximum dimension) ( 30196971 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 ) Youthful appearance (self-reported) ( 32339537 )
Novel Interactors		None recorded	5 novel interactors: ARPC3 CXADR KXD1 OR10J1 TRIM4
Interacting Genes		127 interacting genes: AATF ABL1 ACTA1 ACTB ACTG1 AKT1 AMPH APOE ARHGEF40 BAG1 BRSK1 BRSK2 CALM1 CAMK2A CAPN1 CASP1 CASP2 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CHEK1 CHEK2 CREBBP CSNK2A1 CTSD DUSP1 DYRK1A DYRK2 EGFR EP300 F2 FKBP1A FYN GSK3A GSK3B HDAC6 HNRNPC HOOK3 HSPA8 HTRA1 LCK LGMN LRRK2 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MARCHF7 MARK1 MARK3 MARK4 MASP1 MDM2 MELK NPEPPS OGT OTUB1 PACSIN1 PDIA2 PEG10 PHKG1 PIK3R1 PIN1 PKN1 PLCG1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP2R5A PPP5C PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCZ PSEN1 PTGES3 PTK2B PTPA PTPN11 PWP2 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SIK1 SNCA SPTB SQSTM1 SRC SRPK1 SRPK2 STAU1 STUB1 STXBP1 SYK TRAF6 TRIM11 TTBK1 TUBA1B TUBA4A TUBB TUBB3 UBB UBE2D2 UBE2D3 UBE2W USP9Y YWHAB YWHAZ	416 interacting genes: ABL1 ACIN1 ACTB ACTG1 ADAMTS18 ADGRG5 ADPRH AHCYL1 AKAP13 AKT1 ALDOA ALKBH3 ALPL AMER1 AMMECR1L ANK3 ANKFY1 ANKRD35 AP1M1 APEX1 APOBEC3C APP ARFGEF3 ARGLU1 ARHGAP12 ARK2N ARL6IP4 ARPC1B ARSG ASL ATAT1 AURKA BAG3 BAIAP2 BAZ1A BCL9L BCLAF1 BTG3 BUD13 C16orf78 C1orf35 C4orf46 CACNG2 CADPS2 CALCOCO1 CAMSAP1 CAND1 CARD11 CARHSP1 CASK CBLN4 CCDC28A CCDC86 CCDC88B CCDC97 CCM2 CDC42EP4 CDK12 CDK13 CDK7 CEP170 CHD1L CHD2 CHEK2 CHERP CHTOP CHUK CLASP1 CLASP2 CLASRP CLCNKA CLDN19 CLK1 CLK2 CLK3 CLU COIL CPLANE1 CPSF7 CRTC1 CSAG1 CTNNBL1 DAW1 DBF4B DCAF10 DDX39B DDX3X DDX46 DDX50 DDX6 DHX8 DIDO1 DNAH6 DNAH9 DNAJC8 DOCK3 DRAP1 DRG1 DYRK1A ECT2 EED EFCAB12 EGLN2 EIF1AY EIF3A EIF4B EIF4G1 ELAVL3 ELP6 ENOX2 ENSA EPB41L1 EPB41L4A EPB41L4B EPM2A EPS8L1 EPS8L3 ERBB3 ERC1 ERCC3 ERN1 EVI5L EXOSC8 F5 FAM43A FAM76B FAM90A1 FBXO24 FCHO1 FGF12 FGFR3 FIP1L1 FMNL1 FOXN3 FXR1 FXR2 GABARAP GABARAPL1 GBF1 GCC2 GGCX GHR GLRA4 GNGT2 GSE1 GTF2E1 GTPBP4 GXYLT2 H2BC12 HBS1L HERC3 HIRIP3 HIVEP1 HMCN2 HMGA1 HMGN2 HMGN3 HMGXB4 HNRNPA1 HNRNPA3 HNRNPC HNRNPK HOMER3 HOXB6 HTATSF1 IFIT5 IRS2 ISLR JMJD1C KANK2 KCNN2 KHDRBS1 KIF11 KRT78 LBR LCA5 LCE3D LDHA LDHC LGMN LINC00322 LMNA LMNB1 LMO7 LRRC34 LRRC52 LRRN4CL LUC7L LUC7L2 LUC7L3 LUZP4 MAB21L2 MACF1 MACO1 MAGEB1 MAP1S MAP3K20 MAP4 MAP7 MAP7D1 MAPKAPK3 MAPKAPK5 MAPRE1 MAPT MARCHF10 MAST2 MATR3 MCOLN3 MDC1 MDK MIB2 MIPOL1 MMP23B MPP3 MRPS6 MSI2 MTCL1 MYCBP2 MYLIP MYO18B MYO1E MZT2B NADK NAGK NCBP3 NCK2 NCL NELFE NGDN NGLY1 NKAP NOLC1 NOM1 NOP16 NOP53 NPM2 NSMCE4A NSRP1 NSUN5P2 NTHL1 NUP50 NXF1 NXPE4 NXT2 OBI1 OCEL1 OTOF PABPC4 PAK4 PALLD PCBP1 PCF11 PDCL3 PDE7B PELI1 PHF6 PHLDB1 PKD1L2 PLEKHA5 PNISR PNMA8B POLB POLDIP3 PPHLN1 PPIA PPIL1 PPP1R13L PRKAA1 PRP4K PRPF38A PRPF38B PRPF40A PRR20A PRR20B PRR20C PRR20D PRR20E PRRC2A PRRC2B PRRC2C PSMA3 PSMD13 PTBP1 PTBP2 PTPN22 RABEP1 RASGRF1 RBM15 RBM15B RBM19 RBM8A RBMX RIPK3 RIT1 RIT2 RNF4 RPL13 RPL22 RPL34 RPL37 RPL39L RPL41 RPLP2 RPS26 RRM2B RRP1 RRP1B RSRC1 RSRC2 RSRP1 RTF1 RWDD2B RXFP1 S100A4 SAFB SART1 SBK1 SCAF1 SDK2 SDR42E1 SEC16B SEC23B SELENOS SERPING1 SGPL1 SIPA1L3 SLAIN2 SLC13A2 SLC17A6 SLC75A1 SLFN5 SLTM SMCHD1 SNIP1 SNRNP27 SNRNP35 SNURF SPDEF SPEN SRC SREK1 SRI SRRM1 SRRM2 SRSF1 SRSF11 SRSF12 SRSF3 SRSF7 SRSF8 SRSF9 SRXN1 STON1 SUPT16H SYCP2 TAF7L TCEANC2 TCOF1 TDP2 TLE4 TLE5 TMPO TMPRSS11A TMSB10 TNFAIP8L2 TNFRSF10C TNIP2 TNS3 TOGARAM1 TOP1 TPD52 TRIM41 TRIP12 TTN TUBA1B TXN U2AF1 U2AF2 UBD UBE2E2 UBR4 UNKL UPF3B USP39 VAC14 VAV2 VRK1 VSTM2L WDR24 WDR5 WDR70 XRCC5 YBX3 YPEL2 YPEL3 YRDC YTHDC1 YTHDC2 ZC3H13 ZCCHC17 ZDHHC5 ZFC3H1 ZFHX4 ZFP91 ZMAT4 ZMYM4 ZNF140 ZNF234 ZNF529 ZNF592 ZNF593 ZNF616 ZRANB2 ZRSR2 ZSCAN12 ZSCAN9
Entrez ID		4137	6733
HPRD ID		01142	04280
Ensembl ID		ENSG00000186868	ENSG00000135250
Uniprot IDs		A0A7I2PJZ2 A0A7I2PLE3 B3KTM0 P10636	A0A994J591 C9J2M4 P78362
PDB IDs		1I8H 2MZ7 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3 5K7N 5MO3 5MP1 5MP3 5MP5 5N5A 5N5B 5NVB 5O3L 5O3O 5O3T 5V5B 5V5C 5ZIA 5ZV3 6BB4 6CVJ 6CVN 6DC8 6DC9 6DCA 6FBW 6FI5 6GK7 6GK8 6GX5 6H06 6HRE 6HRF 6LRA 6N4P 6NK4 6NWP 6NWQ 6ODG 6PXR 6QJH 6QJM 6QJP 6QJQ 6TJO 6TJX 6VH7 6VHA 6VHL 6VI3 6XLI 7EYC 7KQK 7MKF 7MKG 7MKH 7NRQ 7NRS 7NRT 7NRV 7NRX 7P65 7P66 7P67 7P68 7P6A 7P6B 7P6C 7P6D 7P6E 7PQC 7PQP 7QJV 7QJW 7QJX 7QJY 7QJZ 7QK1 7QK2 7QK3 7QK5 7QK6 7QKF 7QKG 7QKH 7QKI 7QKJ 7QKK 7QKL 7QKM 7QKU 7QKV 7QKW 7QKX 7QKY 7QKZ 7QL0 7QL1 7QL2 7QL3 7QL4 7R4T 7R5H 7SP1 7U0Z 7UPE 7UPF 7UPG 7YMN 7YPG 8AZU 8BGS 8BGV 8BYN 8CAQ 8CAX 8FNZ 8FUG 8FYU 8G54 8G55 8G58 8GCK 8KDX 8OH2 8OHI 8OHP 8OI0 8OP0 8OPI 8ORE 8ORF 8ORG 8OT6 8OT9 8OTC 8OTG 8OTH 8OTI 8OTJ 8P34 8PII 8PPO 8Q27 8Q2J 8Q2K 8Q2L 8Q7F 8Q7L 8Q7M 8Q7P 8Q7T 8Q88 8Q8C 8Q8D 8Q8E 8Q8F 8Q8L 8Q8M 8Q8R 8Q8S 8Q8U 8Q8V 8Q8W 8Q8X 8Q8Y 8Q8Z 8Q92 8Q97 8Q98 8Q99 8Q9A 8Q9B 8Q9C 8Q9D 8Q9E 8Q9F 8Q9G 8Q9H 8Q9I 8Q9J 8Q9K 8Q9L 8Q9M 8Q9O 8QCP 8QCR 8QDV 8QJJ 8R3T 8SEH 8SEI 8TTL 8TTN 8UQ7 8V1N 8WCP 8ZWL 8ZWM 8ZX6 9B4L 9B4M 9B4N 9B4O 9BBL 9BBM 9BXI 9BXO 9BXQ 9BXR 9CGX 9CGZ 9CZI 9CZL 9EO7 9EO9 9EOE 9EOG 9EOH 9ERM 9ERN 9ERO 9G13 9GG0 9GG1 9GG6 9H5G 9H5J 9HBB 9MR8	2X7G 5MYV 7ZKX
GO Terms Enriched among Interactors		Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Kinase Activity Protein Modification Process Protein Metabolic Process Tau Protein Binding Intracellular Signal Transduction Protein Phosphorylation Phosphorylation Cytoplasm ATP Binding Cytosol Transferase Activity Nucleotide Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Macromolecule Metabolic Process Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Stress Response To Stress Regulation Of Signaling Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signaling Cassette Negative Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Nucleus Positive Regulation Of Cell Communication Regulation Of Protein-containing Complex Assembly Programmed Cell Death Cell Death Apoptotic Process Tau-protein Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Metabolic Process MAP Kinase Activity Regulation Of Immune System Process Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission	RNA Binding MRNA Processing RNA Splicing MRNA Binding MRNA Metabolic Process Nucleic Acid Binding RNA Processing Nucleus Nuclear Speck RNA Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Processing Spliceosomal Complex Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Splicing Protein-RNA Complex Assembly Macromolecule Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Catalytic Step 2 Spliceosome RNA Transport Negative Regulation Of MRNA Metabolic Process Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Post-transcriptional Regulation Of Gene Expression MRNA Splice Site Recognition Spliceosomal Complex Assembly Ribonucleoprotein Complex Regulation Of Gene Expression Nucleolus Nucleobase-containing Compound Transport Regulation Of Microtubule Polymerization RNA Export From Nucleus RS Domain Binding MRNA Export From Nucleus Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Translation Microtubule Cortical Microtubule Cytoskeleton Negative Regulation Of Gene Expression