MAPT and AKT1

Number of citations of the paper that reports this interaction (PMID 19014373)
9

Data Source:
BioGRID (enzymatic study)

		MAPT	AKT1
Gene Name		microtubule-associated protein tau	v-akt murine thymoma viral oncogene homolog 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Axon Growth Cone Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Tubulin Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Plasma Membrane Cell-cell Junction Microtubule Cytoskeleton Ciliary Basal Body
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Apolipoprotein Binding Lipoprotein Particle Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Kinase Activity Enzyme Binding Nitric-oxide Synthase Regulator Activity Identical Protein Binding Phosphatidylinositol-3,4-bisphosphate Binding 14-3-3 Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Adult Walking Behavior Axon Cargo Transport Regulation Of Autophagy Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of Intracellular Transport Positive Regulation Of Axon Extension Mitochondrion Transport Along Microtubule Axon Extension Generation Of Neurons Regulation Of Microtubule-based Movement	Protein Import Into Nucleus, Translocation Osteoblast Differentiation Maternal Placenta Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Glucose Metabolic Process Translation Regulation Of Translation Cellular Protein Modification Process Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Nitric Oxide Biosynthetic Process Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Response To Oxidative Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Germ Cell Development Aging Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Apoptotic Mitochondrial Changes Response To Heat Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Sodium Ion Transport Positive Regulation Of Glucose Metabolic Process Negative Regulation Of Endopeptidase Activity Regulation Of Neuron Projection Development Glucose Transport Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Cell Projection Organization Cell Differentiation Protein Catabolic Process Platelet Activation Hyaluronan Metabolic Process Positive Regulation Of Cell Growth Regulation Of Cell Migration Endocrine Pancreas Development T Cell Costimulation Regulation Of Myelination Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Fatty Acid Beta-oxidation Response To Food Positive Regulation Of Cellular Protein Metabolic Process Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Peptidyl-serine Phosphorylation Response To Fluid Shear Stress Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Cell Size Negative Regulation Of Proteolysis Positive Regulation Of Vasoconstriction Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitric Oxide Metabolic Process Positive Regulation Of Glucose Import Negative Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Striated Muscle Cell Differentiation Mammary Gland Epithelial Cell Differentiation Glycogen Cell Differentiation Involved In Embryonic Placenta Development Labyrinthine Layer Blood Vessel Development Membrane Organization Response To UV-A Cellular Response To Mechanical Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Hypoxia Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Neuron Death Regulation Of Cell Cycle Checkpoint Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins Signaling by Wnt Platelet Aggregation (Plug Formation) Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of beta-cell development PI3K/AKT activation PI-3K cascade RNF mutants show enhanced WNT signaling and proliferation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling DAP12 interactions Regulation of mRNA stability by proteins that bind AU-rich elements GAB1 signalosome misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR GPCR downstream signaling Signaling by VEGF AKT phosphorylates targets in the nucleus Downstream signal transduction Regulation of gene expression in beta cells Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling Translocation of GLUT4 to the plasma membrane deactivation of the beta-catenin transactivating complex VEGFA-VEGFR2 Pathway Metabolism of nitric oxide G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN eNOS activation and regulation Intrinsic Pathway for Apoptosis Butyrate Response Factor 1 (BRF1) destabilizes mRNA Innate Immune System Signalling by NGF CTLA4 inhibitory signaling AKT-mediated inactivation of FOXO1A Integrin alphaIIb beta3 signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR eNOS activation TCF dependent signaling in response to WNT KSRP destabilizes mRNA GPVI-mediated activation cascade Signaling by WNT in cancer
Drugs			Adenosine triphosphate Arsenic trioxide Inositol 1,3,4,5-Tetrakisphosphate N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
Diseases
GWAS		Bone mineral density ( 22504420) Head circumference (infant) ( 22504419) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Parkinson's disease ( 20711177 21292315 19915575 22438815 20070850 21044948 21738487) Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		78 interactors: AATF ABL1 ACTB AKT1 APOE APP ARHGEF40 BAG1 CALM1 CAMK2A CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CSNK1A1 CSNK1D CSNK2A1 EP300 FYN GSK3A GSK3B HSPA4 HSPA8 LRRK2 MAPK11 MAPK12 MAPK13 MAPK8 MARCH7 MARK1 MARK2 MARK3 MARK4 OGT PEG10 PHKG1 PIN1 PKN1 PPP2CA PPP2CB PPP2R4 PPP2R5A PPP5C PRKACA PRKAR1A PRKCD PSEN1 PTK2B RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SGK1 SIRT1 SNCA SPTB SRC STAU1 STUB1 STXBP1 SYK TRAF6 TUBA1B TUBA4A TUBB UBB UBC UBE2D2 USP9Y YWHAB YWHAZ	191 interactors: ACAP1 AHNAK AKT1S1 AKT2 AKTIP ALYREF APLP2 APOH APP APPL1 AR ARFIP2 ARHGAP29 ARHGAP32 ATXN1 BAD BCL10 BCL2L1 BCL2L11 BPGM BRAF BRCA1 CAMKK1 CARHSP1 CASP3 CASP9 CCDC88A CDKN1A CDKN1B CDKN1C CHEK1 CHN2 CHUK CLIP3 CLK2 CREB1 CREBBP CSNK2A1 CTNNB1 CYLD DAB2IP DCTN1 DLC1 DNAJB1 DNMT1 EEF1G EIF4EBP1 EP300 ESR1 ESR2 EZH2 FANCA FOXO1 FOXO3 FOXO4 GAB2 GATA1 GATA2 GRB10 GSK3A GSK3B HIST2H2BE HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB ILK IMPDH2 IRAK1 IRS1 ITGB3 ITPR1 ITPR3 JADE1 KAT2B KAT6A KRT10 KTN1 LRRK2 MAP2K4 MAP3K11 MAP3K5 MAP3K8 MAPK14 MAPK8IP1 MAPKAPK2 MAPT MDM2 MDM4 METTL1 MS4A2 MST1R MTCP1 MTOR MUL1 MXD1 NCOA4 NCOR2 NF2 NOS3 NOTCH1 NR4A1 PAK1 PAK6 PDE3B PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PHB2 PI4K2B PIAS1 PIAS2 PIK3R1 PKN2 PLCG1 PLEKHO1 PLXNA1 PPARGC1B PPL PPM1A PPP1CA PPP2CA PPP2R1A PPP2R4 PRG2 PRKCQ PRKCZ PRKDC PTEN PTPN1 RAB3D RAC1 RAF1 RARA RGCC RHEBL1 RICTOR RNF11 RNF115 RPS6KB1 RQCD1 S1PR1 SETDB1 SH2B2 SH3RF1 SIRT1 SIRT6 SKI SKP2 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SORBS2 SORBS3 SRC STAT1 STK3 STK4 TBC1D4 TCL1A TCL1B TCL6 TERF2IP TERT THEM4 TNFSF11 TOPBP1 TRIB3 TSC1 TSC2 TTC3 USP4 UXS1 VEGFA VIM WNK1 WNK4 XIAP YAP1 YBX1 YWHAZ ZFP36L1 ZHX1
Entrez ID		4137	207
HPRD ID		01142	01261
Ensembl ID		ENSG00000186868	ENSG00000142208
Uniprot IDs		B3KTM0 P10636	B0LPE5 B3KVH4 P31749
PDB IDs		1I8H 3FQP 3OVL 4GLR	1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Death Apoptotic Process Death Programmed Cell Death Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin Signaling Pathway Protein Metabolic Process Response To Growth Factor Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Positive Regulation Of Cell Death Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Intracellular Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Regulation Of Cellular Component Organization Regulation Of Protein Phosphorylation Cellular Response To Stimulus Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Immune Response Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Phosphorylation Signal Transduction Regulation Of Proteolysis Regulation Of Signal Transduction	Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Cellular Response To Organic Substance Response To Organic Substance Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Death Death Response To Stimulus Programmed Cell Death Apoptotic Process Regulation Of Catalytic Activity Signal Transduction Signaling Cellular Response To Growth Factor Stimulus Cell Communication Regulation Of Kinase Activity Response To Growth Factor Response To Stress Negative Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Cell Death Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Cell Proliferation Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune System Process Regulation Of Protein Kinase Activity Fc Receptor Signaling Pathway Regulation Of Cellular Process Regulation Of Immune System Process Positive Regulation Of Catalytic Activity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	advance catenin contributes decreasing deregulation doi dramatically foxo1 glioma gliomas implicate inducing insights introduction invasion january micrornas mir mirnas onc oncogene online phosphorylated publication silencing suppressed tissues tumorigenesis unfavorable
Tagcloud (Difference) ?		1795g 2125g abeta37 abeta39 abeta40 dementia dementias e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically shifted tar variants	catenin contributes decreasing deregulation dramatically foxo1 glioma gliomas implicate inducing insights introduction invasion january micrornas mir mirnas onc oncogene online phosphorylated silencing suppressed tissues tumorigenesis unfavorable
Tagcloud (Intersection) ?		advance doi publication