MAPT and RPS6KA1

Number of citations of the paper that reports this interaction (PMID 17512525)
2

Data Source:
BioGRID (enzymatic study)

		MAPT	RPS6KA1
Gene Name		microtubule-associated protein tau	ribosomal protein S6 kinase, 90kDa, polypeptide 1
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Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Axon Growth Cone Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Tubulin Complex	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Apolipoprotein Binding Lipoprotein Particle Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Adult Walking Behavior Axon Cargo Transport Regulation Of Autophagy Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of Intracellular Transport Positive Regulation Of Axon Extension Mitochondrion Transport Along Microtubule Axon Extension Generation Of Neurons Regulation Of Microtubule-based Movement	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Cell Cycle Signal Transduction Synaptic Transmission Axon Guidance Positive Regulation Of Cell Growth Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Positive Regulation Of Hepatic Stellate Cell Activation
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins	Signaling by GPCR CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence CREB phosphorylation L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ERK/MAPK targets Post NMDA receptor activation events Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transmission across Chemical Synapses Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Head circumference (infant) ( 22504419) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Parkinson's disease ( 20711177 21292315 19915575 22438815 20070850 21044948 21738487) Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		78 interactors: AATF ABL1 ACTB AKT1 APOE APP ARHGEF40 BAG1 CALM1 CAMK2A CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CSNK1A1 CSNK1D CSNK2A1 EP300 FYN GSK3A GSK3B HSPA4 HSPA8 LRRK2 MAPK11 MAPK12 MAPK13 MAPK8 MARCH7 MARK1 MARK2 MARK3 MARK4 OGT PEG10 PHKG1 PIN1 PKN1 PPP2CA PPP2CB PPP2R4 PPP2R5A PPP5C PRKACA PRKAR1A PRKCD PSEN1 PTK2B RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SGK1 SIRT1 SNCA SPTB SRC STAU1 STUB1 STXBP1 SYK TRAF6 TUBA1B TUBA4A TUBB UBB UBC UBE2D2 USP9Y YWHAB YWHAZ	51 interactors: ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DLC1 EEF1D EEF2K ESR1 ETV1 FGFR1 FOS GBP2 GMFB GRB2 GSK3B L1CAM MAGI1 MAPK1 MAPK3 MAPT METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PDCD4 PDPK1 PHAX POLDIP3 PPM1G PPP1R3A RPTOR SRF SRSF5 SYK TOB2 TSC2 TTK VCP YBX1 YWHAB
Entrez ID		4137	6195
HPRD ID		01142	03402
Ensembl ID		ENSG00000186868	ENSG00000117676
Uniprot IDs		B3KTM0 P10636	E9PRI4 Q15418
PDB IDs		1I8H 3FQP 3OVL 4GLR	2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Death Apoptotic Process Death Programmed Cell Death Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin Signaling Pathway Protein Metabolic Process Response To Growth Factor Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Positive Regulation Of Cell Death Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Intracellular Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Regulation Of Cellular Component Organization Regulation Of Protein Phosphorylation Cellular Response To Stimulus Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Immune Response Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Phosphorylation Signal Transduction Regulation Of Proteolysis Regulation Of Signal Transduction	Fc Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Innate Immune Response Response To Fibroblast Growth Factor Response To Organonitrogen Compound Cellular Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Cellular Response To Growth Factor Stimulus Regulation Of Immune System Process Immune Response Response To Growth Factor Regulation Of Immune Response Defense Response Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Phosphatidylinositol-mediated Signaling Response To External Stimulus Cellular Response To Hormone Stimulus Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Insulin Receptor Signaling Pathway Response To Peptide Cellular Response To Heat Immune System Process Cell Communication Regulation Of Phosphorylation Response To Temperature Stimulus Response To Peptide Hormone Positive Regulation Of Transcription, DNA-templated Signal Transduction Signaling Positive Regulation Of Gene Expression Response To Stress Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Chemotaxis Cellular Response To Insulin Stimulus
Tagcloud ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 tlr8 tradition
Tagcloud (Difference) ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr2b htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 tlr8 tradition
Tagcloud (Intersection) ?