MAPT and UBE2D2

Number of citations of the paper that reports this interaction (PubMedID 14612456)
0

Data Source:
BioGRID (enzymatic study)

		MAPT	UBE2D2
Description		microtubule associated protein tau	ubiquitin conjugating enzyme E2 D2
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Microtubule Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Growth Cone Axolemma Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Somatodendritic Compartment Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Cell Body Main Axon Membrane Raft Tubulin Complex Glial Cell Projection Neurofibrillary Tangle Axon Cytoplasm	Nucleus Nucleoplasm Cytosol Protein-containing Complex Extracellular Exosome
	Molecular Function	DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Actin Binding Protein Binding Microtubule Binding Tubulin Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Apolipoprotein Binding Dynactin Binding Phosphatidylinositol Binding Identical Protein Binding Sequence-specific DNA Binding Protein-folding Chaperone Binding Protein Phosphatase 2A Binding Hsp90 Protein Binding Lipoprotein Particle Binding Histone-dependent DNA Binding Microtubule Lateral Binding Phosphatidylinositol Bisphosphate Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Microtubule Cytoskeleton Organization Microglial Cell Activation DNA Damage Response Cell-cell Signaling Synapse Assembly Learning Or Memory Memory Response To Lead Ion Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Mitochondrial Membrane Potential RRNA Metabolic Process Axonal Transport Of Mitochondrion Central Nervous System Neuron Development Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Neuron Projection Development Positive Regulation Of Superoxide Anion Generation Regulation Of Chromosome Organization Stress Granule Assembly Cellular Response To Heat Cellular Response To Reactive Oxygen Species Positive Regulation Of Axon Extension Microtubule Polymerization Astrocyte Activation Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Generation Of Neurons Synapse Organization Regulation Of Calcium-mediated Signaling Protein Polymerization Protein Homooligomerization Axon Development Regulation Of Microtubule Cytoskeleton Organization Plus-end-directed Organelle Transport Along Microtubule Regulation Of Mitochondrial Fission Negative Regulation Of Mitochondrial Fission Supramolecular Fiber Organization Axonal Transport Regulation Of Cellular Response To Heat Regulation Of Long-term Synaptic Depression Positive Regulation Of Protein Localization To Synapse Neurofibrillary Tangle Assembly Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Protein Localization Negative Regulation Of Tubulin Deacetylation Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification Process Protein Autoubiquitination Protein K48-linked Ubiquitination
Pathways		Caspase-mediated cleavage of cytoskeletal proteins	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs		Lansoprazole Astemizole Paclitaxel Docetaxel Flortaucipir F-18	(R,R)-2,3-Butanediol
Diseases		Progressive supranuclear palsy (PSP); Steele-Richardson-Olszewski syndrome Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		A body shape index ( 34021172) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alcohol use disorder (consumption score) ( 30336701 33861876) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease ( 31473137) Alzheimer's disease in APOE e4- carriers ( 25778476) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Atrial fibrillation ( 29892015) Brain morphology (MOSTest) ( 32665545) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive performance (processing speed) ( 31598132) Corticobasal degeneration ( 26077951) Experiencing mood swings ( 29500382) Feeling hurt ( 29500382) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 33627673) Handedness (Left-handed vs. non-left-handed) ( 31504236) Handedness (left-handed vs. right-handed) ( 31504236) Handedness (non-right-handed vs right-handed) ( 31504236) HDL cholesterol levels ( 32203549) Head circumference (infant) ( 22504419) Headache ( 29397368) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Hip circumference adjusted for BMI ( 34021172) Household income ( 31844048) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156 31710517) Immature fraction of reticulocytes ( 32888494) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Left–right brain asymmetry ( 33723403) Lumbar spine bone mineral density ( 22504420) Male-pattern baldness ( 29146897 28196072) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (anilides) ( 31015401) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Neuroticism ( 29255261) Neutrophil percentage of white cells ( 32888494) Oily fish consumption ( 32066663) Osteoarthrosis (time to event) ( 32589924) Parkinson's disease ( 31660654 20070850 20711177 21044948 21292315 34064523 21738487 22438815 24511991 24842889 25064009 28892059 19915575) Plasma t-tau levels ( 28100725) Pork consumption ( 32066663) Primary biliary cirrhosis ( 22961000) Progressive supranuclear palsy ( 31059154 30089514 21685912) QRS complex (12-leadsum) ( 27659466) Reaction time ( 29844566) Red blood cell count ( 32888494) Refractive error ( 32231278) Retinal detachment or retinal break ( 31816047) Serum alkaline phosphatase levels ( 33547301) Smoking initiation ( 33082346) Subcortical brain region volumes ( 25607358) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter integrity (mean diffusivity) ( 32358547)	Alzheimer's disease (late onset) ( 30820047) Body mass index ( 26426971) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Leukocyte telomere length ( 32109421)
Interacting Genes		127 interacting genes: AATF ABL1 ACTA1 ACTB ACTG1 AKT1 AMPH APOE ARHGEF40 BAG1 BRSK1 BRSK2 CALM1 CAMK2A CAPN1 CASP1 CASP2 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CHEK1 CHEK2 CREBBP CSNK2A1 CTSD DUSP1 DYRK1A DYRK2 EGFR EP300 F2 FKBP1A FYN GSK3A GSK3B HDAC6 HNRNPC HOOK3 HSPA8 HTRA1 LCK LGMN LRRK2 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MARCHF7 MARK1 MARK3 MARK4 MASP1 MDM2 MELK NPEPPS OGT OTUB1 PACSIN1 PDIA2 PEG10 PHKG1 PIK3R1 PIN1 PKN1 PLCG1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP2R5A PPP5C PRKACA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCI PRKCZ PSEN1 PTGES3 PTK2B PTPA PTPN11 PWP2 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SIK1 SNCA SPTB SQSTM1 SRC SRPK1 SRPK2 STAU1 STUB1 STXBP1 SYK TRAF6 TRIM11 TTBK1 TUBA1B TUBA4A TUBB TUBB3 UBB UBE2D2 UBE2D3 UBE2W USP9Y YWHAB YWHAZ	244 interacting genes: AMFR ANAPC11 ANAPC2 AREL1 ARIH2 ARRDC3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRAP BRCA1 BTRC CADPS2 CBL CBLB CBLC CCNB1 CDKN1B CHFR CNOT4 COP1 CUEDC1 CUL3 DCAF1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL3 FBXO2 FBXO4 FBXO7 FBXW2 HACE1 HECTD1 HECTD3 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC4 HUWE1 ITCH KAT2B KCMF1 LNX1 LNX2 LRSAM1 LTN1 MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF6 MARCHF7 MDM2 MDM4 MEX3A MEX3C MGRN1 MIB1 MIB2 MID1 MID2 MKRN2 MKRN3 MUL1 MYCBP2 MYLIP NAT10 NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NPR1 NSMCE1 OBI1 OTUB1 PDZRN3 PELI1 PHF7 PHRF1 PJA1 PJA2 PMAIP1 POLL POLM PRKN QSOX1 RAD18 RAF1 RAG1 RBCK1 RBX1 RC3H1 RC3H2 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF126 RNF13 RNF130 RNF135 RNF138 RNF14 RNF144A RNF146 RNF149 RNF150 RNF151 RNF166 RNF167 RNF168 RNF170 RNF181 RNF185 RNF186 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF224 RNF25 RNF26 RNF31 RNF34 RNF38 RNF4 RNF40 RNF43 RNF5 RNF7 RNF8 RSPRY1 RTF2 SIAH1 SIAH2 SMURF1 SMURF2 SNCA SOCS6 SPOP STAM2 STK11 STUB1 SYVN1 TOPORS TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM10 TRIM11 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM34 TRIM35 TRIM36 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM46 TRIM47 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM65 TRIM7 TRIM8 TRIP12 TTC3 UBA1 UBA3 UBA5 UBA6 UBASH3B UBD UBE3A UBE3C UBE4A UBE4B UBOX5 UBR1 UBR2 UBR3 UBR4 UBR5 UFM1 UHRF1 UHRF2 UVSSA VHL VPS11 VPS18 WSB1 WWP1 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		4137	7322
HPRD ID		01142	04268
Ensembl ID		ENSG00000186868	ENSG00000131508
Uniprot IDs		A0A7I2PJZ2 A0A7I2PLE3 B3KTM0 P10636	P62837
PDB IDs		1I8H 2MZ7 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3 5K7N 5MO3 5MP1 5MP3 5MP5 5N5A 5N5B 5NVB 5O3L 5O3O 5O3T 5V5B 5V5C 5ZIA 5ZV3 6BB4 6CVJ 6CVN 6DC8 6DC9 6DCA 6FBW 6FI5 6GK7 6GK8 6GX5 6H06 6HRE 6HRF 6LRA 6N4P 6NK4 6NWP 6NWQ 6ODG 6PXR 6QJH 6QJM 6QJP 6QJQ 6TJO 6TJX 6VH7 6VHA 6VHL 6VI3 6XLI 7EYC 7KQK 7MKF 7MKG 7MKH 7NRQ 7NRS 7NRT 7NRV 7NRX 7P65 7P66 7P67 7P68 7P6A 7P6B 7P6C 7P6D 7P6E 7PQC 7PQP 7QJV 7QJW 7QJX 7QJY 7QJZ 7QK1 7QK2 7QK3 7QK5 7QK6 7QKF 7QKG 7QKH 7QKI 7QKJ 7QKK 7QKL 7QKM 7QKU 7QKV 7QKW 7QKX 7QKY 7QKZ 7QL0 7QL1 7QL2 7QL3 7QL4 7R4T 7R5H 7SP1 7U0Z 7UPE 7UPF 7UPG 7YMN 7YPG 8AZU 8BGS 8BGV 8BYN 8CAQ 8CAX 8FNZ 8FUG 8FYU 8G54 8G55 8G58 8GCK 8KDX 8OH2 8OHI 8OHP 8OI0 8OP0 8OPI 8ORE 8ORF 8ORG 8OT6 8OT9 8OTC 8OTG 8OTH 8OTI 8OTJ 8P34 8PII 8PPO 8Q27 8Q2J 8Q2K 8Q2L 8Q7F 8Q7L 8Q7M 8Q7P 8Q7T 8Q88 8Q8C 8Q8D 8Q8E 8Q8F 8Q8L 8Q8M 8Q8R 8Q8S 8Q8U 8Q8V 8Q8W 8Q8X 8Q8Y 8Q8Z 8Q92 8Q97 8Q98 8Q99 8Q9A 8Q9B 8Q9C 8Q9D 8Q9E 8Q9F 8Q9G 8Q9H 8Q9I 8Q9J 8Q9K 8Q9L 8Q9M 8Q9O 8QCP 8QCR 8QDV 8QJJ 8R3T 8SEH 8SEI 8TTL 8TTN 8UQ7 8V1N 8WCP 8ZWL 8ZWM 8ZX6 9B4L 9B4M 9B4N 9B4O 9BBL 9BBM 9BXI 9BXO 9BXQ 9BXR 9CGX 9CGZ 9CZI 9CZL 9EO7 9EO9 9EOE 9EOG 9EOH 9ERM 9ERN 9ERO 9G13 9GG0 9GG1 9GG6 9H5G 9H5J 9HBB 9MR8	1UR6 1W4U 2CLW 2ESK 2ESO 2ESP 2ESQ 3A33 3JVZ 3JW0 3L1Y 3TGD 3ZNI 4A49 4A4B 4A4C 4AUQ 4DDG 4DDI 4LDT 4V3K 4V3L 4WZ3 5D0K 5D0M 5D1K 5D1L 5D1M 5EDV 5MNJ 5ULF 5ULH 5ULK 5VZW 5ZBU 6HPR 6M2C 6SQO 6SQR 6SQS 6TTU 6W7Z 6W9D 7AI0 7AI1 7BOL 7R71 8B3I 8GBQ 8GCB 8GRM 8JWJ 8JWU 8V0D 8VK8 8VK9
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Kinase Activity Protein Modification Process Protein Metabolic Process Tau Protein Binding Intracellular Signal Transduction Protein Phosphorylation Phosphorylation Cytoplasm ATP Binding Cytosol Transferase Activity Nucleotide Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Macromolecule Metabolic Process Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cellular Component Organization Cellular Response To Stress Response To Stress Regulation Of Signaling Regulation Of Cell Communication Regulation Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signaling Cassette Negative Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Nucleus Positive Regulation Of Cell Communication Regulation Of Protein-containing Complex Assembly Programmed Cell Death Cell Death Apoptotic Process Tau-protein Kinase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Localization Regulation Of Protein Metabolic Process MAP Kinase Activity Regulation Of Immune System Process Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Zinc Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Metal Ion Binding Catabolic Process Protein Autoubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Protein Monoubiquitination Response To Stress Regulation Of Signal Transduction Immune System Process Cellular Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Protein Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Negative Regulation Of Signaling Negative Regulation Of Cell Communication Ubiquitin Binding Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Canonical NF-kappaB Signal Transduction Defense Response To Symbiont
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