MAPT and MARK1

Number of citations of the paper that reports this interaction (PMID 10090741)
67

Data Source:
HPRD (in vitro)

		MAPT	MARK1
Gene Name		microtubule-associated protein tau	MAP/microtubule affinity-regulating kinase 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Axon Growth Cone Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Tubulin Complex	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Apolipoprotein Binding Lipoprotein Particle Binding	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau-protein Kinase Activity Phosphatidic Acid Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Adult Walking Behavior Axon Cargo Transport Regulation Of Autophagy Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of Intracellular Transport Positive Regulation Of Axon Extension Mitochondrion Transport Along Microtubule Axon Extension Generation Of Neurons Regulation Of Microtubule-based Movement	Neuron Migration Protein Phosphorylation Cytoskeleton Organization Wnt Signaling Pathway Intracellular Signal Transduction
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Head circumference (infant) ( 22504419) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Parkinson's disease ( 20711177 21292315 19915575 22438815 20070850 21044948 21738487) Progressive supranuclear palsy ( 21685912)	Bipolar disorder ( 22205951) Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		78 interactors: AATF ABL1 ACTB AKT1 APOE APP ARHGEF40 BAG1 CALM1 CAMK2A CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CSNK1A1 CSNK1D CSNK2A1 EP300 FYN GSK3A GSK3B HSPA4 HSPA8 LRRK2 MAPK11 MAPK12 MAPK13 MAPK8 MARCH7 MARK1 MARK2 MARK3 MARK4 OGT PEG10 PHKG1 PIN1 PKN1 PPP2CA PPP2CB PPP2R4 PPP2R5A PPP5C PRKACA PRKAR1A PRKCD PSEN1 PTK2B RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SGK1 SIRT1 SNCA SPTB SRC STAU1 STUB1 STXBP1 SYK TRAF6 TUBA1B TUBA4A TUBB UBB UBC UBE2D2 USP9Y YWHAB YWHAZ	7 interactors: CCDC102B GJA5 MAP2 MAP4 MAPT STK11 TAOK1
Entrez ID		4137	4139
HPRD ID		01142	07353
Ensembl ID		ENSG00000186868	ENSG00000116141
Uniprot IDs		B3KTM0 P10636	B4DIB3 Q9P0L2
PDB IDs		1I8H 3FQP 3OVL 4GLR	2HAK 3OSE
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Death Apoptotic Process Death Programmed Cell Death Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin Signaling Pathway Protein Metabolic Process Response To Growth Factor Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Positive Regulation Of Cell Death Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Intracellular Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Regulation Of Cellular Component Organization Regulation Of Protein Phosphorylation Cellular Response To Stimulus Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Immune Response Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Phosphorylation Signal Transduction Regulation Of Proteolysis Regulation Of Signal Transduction	Organelle Localization Microtubule Cytoskeleton Organization Execution Phase Of Apoptosis Positive Regulation Of Axonogenesis Axonogenesis Vasomotion Microtubule Sliding AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling TCR Signalosome Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Establishment Of Cell Polarity Neuron Projection Morphogenesis Atrial Ventricular Junction Remodeling Pulmonary Valve Formation Foramen Ovale Closure Positive Regulation Of Cell Communication By Chemical Coupling Cell Morphogenesis Involved In Differentiation Microtubule-based Process Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Establishment Or Maintenance Of Cell Polarity Cell Part Morphogenesis Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Chemical Coupling Regulation Of Membrane Depolarization During Action Potential AV Node Cell To Bundle Of His Cell Communication Neuron Development Apoptotic Process Positive Regulation Of Neuron Projection Development Anatomical Structure Morphogenesis Programmed Cell Death Negative Regulation Of Glomerular Filtration Cell Cycle Process Cell Death Death Cell Morphogenesis Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Mitral Valve Development SA Node Cell Action Potential Regulation Of Renin Secretion Into Blood Stream Anoikis Cellular Response To UV-B Regulation Of Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Neuron Differentiation Cytoskeleton Organization Activation Of Protein Kinase Activity
Tagcloud ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	backgroundprocess behavior broadly conclusionsthe coping eating engagement improvements informed intervention inverted mark0 mark2 mark5 mediators methods108 motivation motivational pmblc pmlbc question r2 resultsthe specified theoretical theoretically theories underpinning
Tagcloud (Difference) ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	backgroundprocess behavior broadly conclusionsthe coping eating engagement improvements informed intervention inverted mark0 mark2 mark5 mediators methods108 motivation motivational pmblc pmlbc question r2 resultsthe specified theoretical theoretically theories underpinning
Tagcloud (Intersection) ?