MAPT and CDK5R1

Number of citations of the paper that reports this interaction (PMID 19527721)
4

Data Source:
BioGRID (enzymatic study)

		MAPT	CDK5R1
Gene Name		microtubule-associated protein tau	cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Microtubule Associated Complex Plasma Membrane Axoneme Axon Growth Cone Nuclear Periphery Cytoplasmic Ribonucleoprotein Granule Tubulin Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Cyclin-dependent Protein Kinase 5 Holoenzyme Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding Apolipoprotein Binding Lipoprotein Particle Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Cyclin-dependent Protein Kinase 5 Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Adult Walking Behavior Axon Cargo Transport Regulation Of Autophagy Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of Intracellular Transport Positive Regulation Of Axon Extension Mitochondrion Transport Along Microtubule Axon Extension Generation Of Neurons Regulation Of Microtubule-based Movement	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Neuron Migration Neuron Cell-cell Adhesion G-protein Coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Cell Proliferation Embryo Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Serine Phosphorylation Of STAT3 Protein Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Targeting To Membrane
Pathways		Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins	Axon guidance Semaphorin interactions CRMPs in Sema3A signaling
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Head circumference (infant) ( 22504419) Interstitial lung disease ( 23583980) Intracranial volume ( 22504418) Parkinson's disease ( 20711177 21292315 19915575 22438815 20070850 21044948 21738487) Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		78 interactors: AATF ABL1 ACTB AKT1 APOE APP ARHGEF40 BAG1 CALM1 CAMK2A CAPN2 CASP1 CASP3 CASP6 CASP7 CASP8 CDK1 CDK2 CDK5 CDK5R1 CSNK1A1 CSNK1D CSNK2A1 EP300 FYN GSK3A GSK3B HSPA4 HSPA8 LRRK2 MAPK11 MAPK12 MAPK13 MAPK8 MARCH7 MARK1 MARK2 MARK3 MARK4 OGT PEG10 PHKG1 PIN1 PKN1 PPP2CA PPP2CB PPP2R4 PPP2R5A PPP5C PRKACA PRKAR1A PRKCD PSEN1 PTK2B RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 S100B SGK1 SIRT1 SNCA SPTB SRC STAU1 STUB1 STXBP1 SYK TRAF6 TUBA1B TUBA4A TUBB UBB UBC UBE2D2 USP9Y YWHAB YWHAZ	31 interactors: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MAPT MTUS2 NEDD4 NES NOTCH2NL ODF1 PAK1 SET SIAH1 STXBP1 TSC22D4 TTBK1
Entrez ID		4137	8851
HPRD ID		01142	04586
Ensembl ID		ENSG00000186868	ENSG00000176749
Uniprot IDs		B3KTM0 P10636	Q15078 Q8N619
PDB IDs		1I8H 3FQP 3OVL 4GLR	1H4L 1UNG 1UNH 1UNL 3O0G
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Death Apoptotic Process Death Programmed Cell Death Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin Signaling Pathway Protein Metabolic Process Response To Growth Factor Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Protein Modification Process Positive Regulation Of Cell Death Positive Regulation Of Catalytic Activity Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Intracellular Signal Transduction Signaling Positive Regulation Of Metabolic Process Cell Communication Regulation Of Kinase Activity Regulation Of Cellular Component Organization Regulation Of Protein Phosphorylation Cellular Response To Stimulus Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus Immune Response Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Phosphorylation Signal Transduction Regulation Of Proteolysis Regulation Of Signal Transduction	Generation Of Neurons Nervous System Development Neurogenesis Establishment Of Localization In Cell Neuron Projection Development Cellular Localization Neuron Differentiation Cell Differentiation Cell Projection Organization Neuron Development Multicellular Organismal Development Vesicle-mediated Transport Regulation Of Organelle Organization Regulation Of Neurogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Organization Developmental Process Cell Morphogenesis Involved In Differentiation Exocytosis Axonogenesis Synaptic Vesicle Transport Regulation Of Neuron Differentiation Cell Morphogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Morphogenesis Cell Development Regulation Of Cell Development System Development Cell Part Morphogenesis Organelle Localization Neuron Projection Morphogenesis Receptor Catabolic Process Anatomical Structure Development Synapse Organization Regulation Of Cytoskeleton Organization Secretion By Cell Brain Development Receptor Metabolic Process Response To Abiotic Stimulus Head Development Establishment Of Vesicle Localization Negative Regulation Of Neuron Death Vesicle Localization Axon Guidance Regulation Of Cell Differentiation Secretion Anatomical Structure Morphogenesis Regulation Of Cell Cycle Locomotion
Tagcloud ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?		1795g 2125g abeta37 abeta39 abeta40 advance dementia dementias doi e599k ejhg fus g709s genetics genotyping granulin grn harbored hek293 journal lewy neuropathological pd psen1 publically publication shifted tar variants	10a 200c 30a 30c arhgap5 cd36 cdh2 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?