AKT1 and ARHGEF28

Number of citations: 49 (PubMedID 34941261)
Data Source: BioGRID (enzymatic study)

		AKT1	ARHGEF28
Name		AKT serine/threonine kinase 1	Rho guanine nucleotide exchange factor 28
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Spindle Cytosol Plasma Membrane Cell-cell Junction Cilium Cell Cortex Microtubule Cytoskeleton Membrane Lamellipodium Vesicle Protein-containing Complex Ciliary Basal Body Postsynapse Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Kinase Activity Transferase Activity Enzyme Binding Kinase Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding 14-3-3 Protein Binding Potassium Channel Activator Activity Protein Serine Kinase Activity TORC2 Complex Binding	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Osteoblast Differentiation Maternal Placenta Development Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Cytoplasmic Translation Complement Receptor Mediated Signaling Pathway Sphingosine-1-phosphate Receptor Signaling Pathway Glycogen Metabolic Process Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Glucose Metabolic Process Gluconeogenesis Translational Initiation Regulation Of Translation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Nitric Oxide Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Response To Oxidative Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Germ Cell Development Nervous System Development Cell Population Proliferation Insulin Receptor Signaling Pathway Apoptotic Mitochondrial Changes Cellular Response To Starvation Response To Heat Response To Hormone Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Fibroblast Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Sodium Ion Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Neuron Projection Development Negative Regulation Of Macroautophagy Phosphorylation Cell Migration Protein Ubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Mammalian Oogenesis Stage Cell Differentiation Protein Catabolic Process Positive Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Costimulation Negative Regulation Of Protein Ubiquitination Regulation Of Myelination Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Endodeoxyribonuclease Activity Response To Food Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Stress Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Amino Acid Starvation Response To Fluid Shear Stress Protein K29-linked Ubiquitination Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Decreased Oxygen Levels SREBP-SCAP Complex Retention In Endoplasmic Reticulum TRNA Stabilization Calcium Import Into The Mitochondrion PERK-mediated Unfolded Protein Response TORC1 Signaling Glucose Homeostasis Regulation Of Apoptotic Process Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Anoikis Regulation Of MRNA Stability Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Cilium Assembly Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Nitric Oxide Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of Organ Growth Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Behavioral Response To Pain Positive Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Protein Maturation Excitatory Postsynaptic Potential Response To Growth Hormone Regulation Of Vesicle-mediated Transport Mammary Gland Epithelial Cell Differentiation Labyrinthine Layer Blood Vessel Development Protein Localization To Cilium Response To UV-A Response To Growth Factor Protein Localization To Endoplasmic Reticulum Protein K11-linked Ubiquitination Cellular Response To Calcium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Tricarboxylic Acid Metabolic Process Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Cellular Response To Rapamycin Protein K6-linked Ubiquitination Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Execution Phase Of Apoptosis Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Postsynapse Organization TRNA (guanine-N7)-methylation Regulation Of TRNA Methylation Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus CGAS/STING Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Negative Regulation Of CGAS/STING Signaling Pathway Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Cellular Response To Peptide Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cilium Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Maturation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Nerve Growth Factor Stimulus Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Lymphocyte Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Morphogenesis Central Nervous System Neuron Axonogenesis Cell Differentiation Regulation Of Rho Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Neurofilament Cytoskeleton Organization
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation MTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Mitochondrial unfolded protein response (UPRmt) High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	EPHB-mediated forward signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		ATP Arsenic trioxide Genistein Inositol 1,3,4,5-Tetrakisphosphate Resveratrol Archexin Enzastaurin Perifosine N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine	None
Diseases		PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Endometrial cancer ( 27135401 ) Endometrial endometrioid carcinoma ( 27135401 ) HDL cholesterol ( 24097068 25961943 30275531 ) HDL cholesterol levels ( 28334899 32203549 ) Neutrophil count ( 32888494 ) Vitamin C levels ( 33203707 )	Age-related hearing impairment ( 34108613 ) Chin dimples ( 27182965 ) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821 ) HDL cholesterol ( 30275531 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hodgkin's lymphoma ( 34216518 ) Mean spheric corpuscular volume ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Vaginal microbiome composition (Shannon diversity index) ( 32723796 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 )
Interacting Genes		396 interacting genes: ABI1 ABRAXAS1 ACAP1 ACAT2 AGAP2 AGR3 AHNAK AHSA1 AKT1S1 AKT2 AKTIP ALYREF AMBRA1 APLP2 APOE APOH APP APPL1 AR ARAF ARFIP2 ARHGAP9 ARHGEF16 ARHGEF28 ARNT ATXN1 AURKA BABAM1 BAD BAG6 BCL10 BCL2L1 BCL2L11 BCL3 BECN1 BEX1 BLVRA BPGM BRAF BRCA1 BTRC BUB1 C1orf174 CAMKK1 CARHSP1 CASC3 CASP3 CASP9 CASTOR1 CBLC CCDC88A CCND2 CCNE1 CCNF CCNI CCT2 CD44 CDC37 CDH1 CDK1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CEP57L1 CEP76 CGGBP1 CHEK1 CHUK CLASP2 CLIP3 CLK2 CMTM8 CNKSR3 CNOT9 CREB1 CREBBP CSNK2A1 CTDP1 CTDSP2 CTNNA1 CTNNB1 CYLD DAB2IP DCTN1 DDIT4L DLC1 DNAJB1 DNMT1 EEF1G EFHC1 EIF4EBP1 ELAVL1 EMSY ENO2 EP300 EPHA2 EPSTI1 ERBB2 ESR1 ESR2 EZH2 FAF1 FAM168A FANCA FANCI FASN FBXO31 FBXW7 FGFR4 FOXO1 FOXO3 FOXO4 FUS FXN GAB1 GAB2 GATA1 GATA2 GET4 GFAP GJA1 GLIS2 GMPPA GPT2 GRB10 GRIN2A GSK3A GSK3B H2BC21 H2BC3 HEATR3 HIF1A HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB IL13RA2 IL24 ILK IMPDH2 IRAK1 IRS1 ISCA2 ITCH ITGB3 ITPKB ITPR1 ITPR3 IWS1 JADE1 KANK1 KAT2A KAT2B KAT6A KDELR2 KLHL3 KLRC1 KMT2D KRT10 LANCL2 LATS2 LRRK2 LTB4R2 MAGEB1 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K11 MAP3K5 MAP3K8 MAPK4 MAPK8 MAPK8IP1 MAPK9 MAPKAP1 MAPKAPK2 MAPT MARK4 MATK MDM2 MDM4 MEF2D MESD METTL1 MLF2 MLH3 MOK MRC2 MS4A2 MSH2 MST1R MTA3 MTCP1 MTOR MTUS2 MUL1 MXD1 MYC NCF2 NCKIPSD NCOA4 NCOR2 NEDD4 NEDD4L NF1 NF2 NGB NHERF1 NIBAN1 NKD1 NLGN3 NOL4 NOS3 NOTCH1 NR4A1 NRAS NRIP2 NSD3 OFD1 OSBPL11 OSGIN1 OTUD1 OXSR1 PAK1 PCGF2 PCK1 PDE3A PDE3B PDGFRA PDHB PDK1 PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PFKP PHB2 PI4K2B PIAS1 PIAS2 PICK1 PIK3CA PIK3R1 PIP5K1C PKN2 PLCG1 PLEKHO1 PLP1 PLXNA1 PMS2 POP4 POP7 PPARGC1B PPL PPM1A PPM1H PPP1CA PPP1R11 PPP2CA PPP2R1A PRG2 PRKAR1A PRKCQ PRKCZ PRKDC PSMC5 PSRC1 PTEN PTGDS PTPA PTPN1 PTPN11 PTPN3 PYCR3 PYGO2 RAB3D RAC1 RAF1 RAP1GDS1 RARA RASL10B RASSF1 REPS1 REX1BD RGCC RHEBL1 RNF11 RNF115 RPS6KB1 RUVBL2 S100A14 S1PR1 SERPINB5 SETDB1 SFMBT2 SH2B2 SH3RF1 SHANK2 SHQ1 SIRPA SIRT1 SIRT6 SKI SKP2 SLFN5 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SNCB SORBS1 SORBS2 SOX4 SP1 SP3 SPACA6 SPATA33 SRC SRPK2 SRR SSH1 ST14 STAT1 STK11 STK3 STK4 STOX1 SULT4A1 SUPT6H SYTL1 TBC1D4 TBC1D7 TBCE TCL1A TCL1B TCL6 TEAD2 TERF2IP TERT TFF1 THEM4 THRSP TLR2 TMCC2 TNFRSF1A TNFSF11 TNK2 TOPBP1 TP53 TRAF6 TRIB3 TRIM13 TRIM24 TRIT1 TRMT2B TSC1 TSC2 TTC3 UBE2S UCHL1 UHRF1 URI1 USP10 USP4 USP50 UXS1 VEGFA VHL VIM WDR53 WEE1 WNK1 WNK4 XAF1 XIAP YAP1 YBX1 YIF1B YWHAZ ZC3HAV1 ZFP36L1 ZHX1 ZNF691 ZRANB1	8 interacting genes: AKT1 CTAG1A CTAG1B MAPK8IP1 RHOA TARDBP YWHAE YWHAH
Entrez ID		207	64283
HPRD ID		01261	15244
Ensembl ID		ENSG00000142208	ENSG00000214944
Uniprot IDs		B0LPE5 B3KVH4 P31749	Q8N1W1
PDB IDs		1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 5KCV 6BUU 6CCY 6HHF 6HHG 6HHH 6HHI 6HHJ 6NPZ 6S9W 6S9X 7APJ 7MYX 7NH4 7NH5 8JOW 8UVY 8UW2 8UW7 8UW9 8ZPU	6BC0 6BC1
GO Terms Enriched among Interactors		Intracellular Signal Transduction Regulation Of Signal Transduction Cytosol Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Stress Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Developmental Process Positive Regulation Of Protein Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Programmed Cell Death Negative Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Kinase Activity Cellular Response To Oxygen-containing Compound Regulation Of Cell Cycle Protein Kinase Activity Regulation Of Protein Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Protein Modification Process Regulation Of Phosphorus Metabolic Process MAPK Cascade Protein Serine Kinase Activity Protein Kinase Binding Regulation Of Protein Modification Process Regulation Of Apoptotic Signaling Pathway	Intracellular Receptor Signaling Pathway Substantia Nigra Development Neural Nucleus Development Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Protein Phosphorylation Protein Localization To Endoplasmic Reticulum Regulation Of Phosphorylation Identical Protein Binding TRNA Threonylcarbamoyladenosine Metabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway TRNA Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Modification Process Regulation Of Toll-like Receptor Signaling Pathway Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Sodium Ion Transport Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Migration Regulation Of Metal Ion Transport Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of TRNA Methylation Golgi To Plasma Membrane Transport Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Positive Regulation Of Nucleocytoplasmic Transport Glucocorticoid Catabolic Process Dentate Gyrus Mossy Fiber Nuclear Inner Membrane Organization Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Regulation Of T Cell Activation RNA Stabilization Enzyme Binding Negative Regulation Of RNA Catabolic Process Positive Regulation Of Organelle Assembly Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Protein Kinase Binding Response To Heat Cytoplasm Regulation Of Neuron Projection Development Negative Regulation Of Protein Localization To Lysosome Endothelial Cell Migration