Description |
AKT serine/threonine kinase 1 |
phosphatase and tensin homolog |
Image |
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Cellular Component |
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Molecular Function |
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- Phosphatidylinositol-3-phosphate Phosphatase Activity
- Phosphoprotein Phosphatase Activity
- Protein Serine/threonine Phosphatase Activity
- Protein Tyrosine Phosphatase Activity
- Protein Binding
- Beta-catenin Binding
- Lipid Binding
- Anaphase-promoting Complex Binding
- Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity
- Hydrolase Activity
- Phosphatase Activity
- Enzyme Binding
- PDZ Domain Binding
- Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity
- Identical Protein Binding
- Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
- Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
- Phosphatidylinositol Phosphate Phosphatase Activity
- Molecular Function Inhibitor Activity
- Ubiquitin-specific Protease Binding
- Ubiquitin Ligase Activator Activity
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Biological Process |
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Pathways |
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Drugs |
- ATP
- Arsenic trioxide
- Genistein
- Inositol 1,3,4,5-Tetrakisphosphate
- Resveratrol
- Archexin
- Enzastaurin
- Perifosine
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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Diseases |
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GWAS |
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Interacting Genes |
396 interacting genes:
ABI1
ABRAXAS1
ACAP1
ACAT2
AGAP2
AGR3
AHNAK
AHSA1
AKT1S1
AKT2
AKTIP
ALYREF
AMBRA1
APLP2
APOE
APOH
APP
APPL1
AR
ARAF
ARFIP2
ARHGAP9
ARHGEF16
ARHGEF28
ARNT
ATXN1
AURKA
BABAM1
BAD
BAG6
BCL10
BCL2L1
BCL2L11
BCL3
BECN1
BEX1
BLVRA
BPGM
BRAF
BRCA1
BTRC
BUB1
C1orf174
CAMKK1
CARHSP1
CASC3
CASP3
CASP9
CASTOR1
CBLC
CCDC88A
CCND2
CCNE1
CCNF
CCNI
CCT2
CD44
CDC37
CDH1
CDK1
CDK4
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CEP57L1
CEP76
CGGBP1
CHEK1
CHUK
CLASP2
CLIP3
CLK2
CMTM8
CNKSR3
CNOT9
CREB1
CREBBP
CSNK2A1
CTDP1
CTDSP2
CTNNA1
CTNNB1
CYLD
DAB2IP
DCTN1
DDIT4L
DLC1
DNAJB1
DNMT1
EEF1G
EFHC1
EIF4EBP1
ELAVL1
EMSY
ENO2
EP300
EPHA2
EPSTI1
ERBB2
ESR1
ESR2
EZH2
FAF1
FAM168A
FANCA
FANCI
FASN
FBXO31
FBXW7
FGFR4
FOXO1
FOXO3
FOXO4
FUS
FXN
GAB1
GAB2
GATA1
GATA2
GET4
GFAP
GJA1
GLIS2
GMPPA
GPT2
GRB10
GRIN2A
GSK3A
GSK3B
H2BC21
H2BC3
HEATR3
HIF1A
HMOX1
HSP90AA1
HSP90AB1
HSPB1
HTT
IKBKB
IL13RA2
IL24
ILK
IMPDH2
IRAK1
IRS1
ISCA2
ITCH
ITGB3
ITPKB
ITPR1
ITPR3
IWS1
JADE1
KANK1
KAT2A
KAT2B
KAT6A
KDELR2
KLHL3
KLRC1
KMT2D
KRT10
LANCL2
LATS2
LRRK2
LTB4R2
MAGEB1
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP3K11
MAP3K5
MAP3K8
MAPK4
MAPK8
MAPK8IP1
MAPK9
MAPKAP1
MAPKAPK2
MAPT
MARK4
MATK
MDM2
MDM4
MEF2D
MESD
METTL1
MLF2
MLH3
MOK
MRC2
MS4A2
MSH2
MST1R
MTA3
MTCP1
MTOR
MTUS2
MUL1
MXD1
MYC
NCF2
NCKIPSD
NCOA4
NCOR2
NEDD4
NEDD4L
NF1
NF2
NGB
NHERF1
NIBAN1
NKD1
NLGN3
NOL4
NOS3
NOTCH1
NR4A1
NRAS
NRIP2
NSD3
OFD1
OSBPL11
OSGIN1
OTUD1
OXSR1
PAK1
PCGF2
PCK1
PDE3A
PDE3B
PDGFRA
PDHB
PDK1
PDK2
PDPK1
PEA15
PFKFB1
PFKFB2
PFKP
PHB2
PI4K2B
PIAS1
PIAS2
PICK1
PIK3CA
PIK3R1
PIP5K1C
PKN2
PLCG1
PLEKHO1
PLP1
PLXNA1
PMS2
POP4
POP7
PPARGC1B
PPL
PPM1A
PPM1H
PPP1CA
PPP1R11
PPP2CA
PPP2R1A
PRG2
PRKAR1A
PRKCQ
PRKCZ
PRKDC
PSMC5
PSRC1
PTEN
PTGDS
PTPA
PTPN1
PTPN11
PTPN3
PYCR3
PYGO2
RAB3D
RAC1
RAF1
RAP1GDS1
RARA
RASL10B
RASSF1
REPS1
REX1BD
RGCC
RHEBL1
RNF11
RNF115
RPS6KB1
RUVBL2
S100A14
S1PR1
SERPINB5
SETDB1
SFMBT2
SH2B2
SH3RF1
SHANK2
SHQ1
SIRPA
SIRT1
SIRT6
SKI
SKP2
SLFN5
SMAD2
SMAD3
SMAD4
SMAD7
SMARCB1
SMARCC1
SNCA
SNCB
SORBS1
SORBS2
SOX4
SP1
SP3
SPACA6
SPATA33
SRC
SRPK2
SRR
SSH1
ST14
STAT1
STK11
STK3
STK4
STOX1
SULT4A1
SUPT6H
SYTL1
TBC1D4
TBC1D7
TBCE
TCL1A
TCL1B
TCL6
TEAD2
TERF2IP
TERT
TFF1
THEM4
THRSP
TLR2
TMCC2
TNFRSF1A
TNFSF11
TNK2
TOPBP1
TP53
TRAF6
TRIB3
TRIM13
TRIM24
TRIT1
TRMT2B
TSC1
TSC2
TTC3
UBE2S
UCHL1
UHRF1
URI1
USP10
USP4
USP50
UXS1
VEGFA
VHL
VIM
WDR53
WEE1
WNK1
WNK4
XAF1
XIAP
YAP1
YBX1
YIF1B
YWHAZ
ZC3HAV1
ZFP36L1
ZHX1
ZNF691
ZRANB1
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376 interacting genes:
AATK
ABCF2
ACTL6A
ADAR
AFP
AKAP12
AKT1
ALYREF
AMOT
ANAPC10
ANAPC7
ANG
ANP32B
ANP32E
ANXA2
AR
ARF4
ARMCX3
ASCC3
ATM
ATP5F1A
ATP5F1C
BCAR1
BEX1
BGLT3
BUB3
CACTIN-AS1
CAD
CALM1
CAMK2G
CAV1
CBL
CCDC180
CCDC47
CCND2
CCT2
CCT3
CCT4
CCT6A
CCT8
CDC27
CEP170
CEP97
CFL1
CHD4
CHGB
CMAS
COPA
COPB1
COPS6
CREB1
CSNK1A1
CSNK2A1
CSNK2A2
CUL4B
CXCL1
CXXC1
DAP3
DAXX
DBN1
DCAF11
DCAF13
DDB1
DDOST
DDX1
DDX21
DDX24
DDX47
DDX50
DHX15
DHX9
DLC1
DLG1
DNAJA1
DNAJA2
DNAJA3
DNAJB6
DNAJC10
DPM1
DRG1
DSP
EEF2
EIF4E
EIF6
EML1
EPHA2
EPRS1
ERBB3
ESR1
EXOSC1
EXOSC2
EXOSC4
EXOSC5
EXOSC7
FARSA
FARSB
FASN
FBL
FBXW11
FLNA
FOXK1
FUBP3
GEMIN4
GNAI1
GNAI2
GNB4
GNL3
GPC4
GSTM2
GTF3C2
GTF3C3
GTF3C5
H2AC4
H2AX
HADHA
HBA1
HNRNPA1
HNRNPA3
HNRNPAB
HNRNPUL1
HSD17B1
HSD17B10
HSP90B1
HSPA4
HSPA4L
HSPA8
HSPBP1
HSPD1
HSPH1
IL24
ILF2
ILF3
INS
IPO5
IPO7
IRS4
ITPRID2
JUP
KBTBD4
KDM1A
KPNB1
LATS1
LGALS1
LIMA1
LINC00839
LINC01198
LINC02023
LMNB1
LRPPRC
LTV1
MAGED2
MAGI2
MAGI3
MAP2K3
MAST1
MAST2
MAST3
MATR3
MCM2
MCM3
MCM5
MCRS1
MDC1
MDN1
METTL26
MEX3C
MKI67
MME
MPRIP
MRPS22
MRPS23
MRPS27
MRPS28
MRPS7
MRPS9
MSH6
MTHFD2
MVP
MYBBP1A
MYC
MYH10
MYL12A
MYO1B
MYO1C
MYO1D
MYOF
NACA
NCBP1
NCF1
NDFIP1
NEDD4
NGB
NHERF1
NHERF2
NOP56
NOP58
NPM3
NUMB
OSGIN1
PBK
PBRM1
PCNA
PDGFRB
PELO
PELP1
PHB1
PHB2
PICK1
PIK3R1
PKM
PLEC
PLK1
POLDIP2
POLR1A
POLR2A
POLR2B
POLR2H
POP1
PPL
PPP1CA
PPP2CA
PRDX1
PRDX3
PRKDC
PRPF19
PRPF8
PSMD3
PSMD4
PSMD7
PTDSS1
PTK7
PURA
PXN
QPCTL
RAD21
RANBP2
RANGAP1
RBBP5
RBM4
RCC2
RCN1
RFC3
RFC4
RFC5
RING1
RNF31
RPL10
RPL10A
RPL12
RPL13
RPL13A
RPL14
RPL17
RPL18A
RPL21
RPL22
RPL22L1
RPL23
RPL23A
RPL27
RPL27A
RPL28
RPL30
RPL31
RPL32
RPL34
RPL36
RPL38
RPL7
RPLP0
RPLP2
RPN2
RPP30
RPP38
RPP40
RPS11
RPS13
RPS15
RPS15A
RPS17
RPS2
RPS20
RPS23
RPS25
RPS26
RPS27
RPS27A
RPS3
RPS4X
RPS5
RPS6
RPS9
RSL1D1
RYBP
S100A8
S100A9
SDC1
SDC4
SDCBP
SEC61A1
SET
SETX
SHARPIN
SHROOM3
SIN3A
SIRT4
SKP1
SLC25A1
SLC25A13
SLC25A3
SLC25A5
SMARCA4
SMARCA5
SMC2
SMC4
SMCHD1
SMURF1
SNAI1
SNRNP200
SNRPA1
SNRPB2
SNRPD1
SNTB2
SNX27
SPOP
SPTAN1
SPTBN1
SRP14
SSB
SSR4
SSRP1
STAG2
STK11
STRAP
SUDS3
SUGP2
TCF25
TCP1
TECR
TERF2IP
THOC2
THOC3
THOC6
TMEFF1
TNKS
TNKS2
TNPO3
TP53
TP53BP1
TRIM25
TRIM28
TRMO
TUBA1B
TUBB
TUBB4B
TUFM
TWIST1
TXN
U2AF1
UBE2I
UBE2L3
UPF1
USP7
USP9X
UTP14A
UTRN
WWP1
WWP2
XRCC5
XRCC6
YAF2
YAP1
YES1
YTHDC2
YTHDF2
ZNF326
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Entrez ID |
207 |
5728 |
HPRD ID |
01261 |
03431 |
Ensembl ID |
ENSG00000142208
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ENSG00000171862
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Uniprot IDs |
B0LPE5
B3KVH4
P31749
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F6KD01
P60484
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PDB IDs |
1H10
1UNP
1UNQ
1UNR
2UVM
2UZR
2UZS
3CQU
3CQW
3MV5
3MVH
3O96
3OCB
3OW4
3QKK
3QKL
3QKM
4EJN
4EKK
4EKL
4GV1
5KCV
6BUU
6CCY
6HHF
6HHG
6HHH
6HHI
6HHJ
6NPZ
6S9W
6S9X
7APJ
7MYX
7NH4
7NH5
8JOW
8UVY
8UW2
8UW7
8UW9
8ZPU
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1D5R
2KYL
4O1V
5BUG
5BZX
5BZZ
7JTX
7JUK
7JUL
7JVX
7PC7
8X3S
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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