AKT1 and EP300

Number of citations of the paper that reports this interaction (PubMedID 15224190)
24

Data Source:
BioGRID (pull down, enzymatic study)
HPRD (in vitro)

		AKT1	EP300
Description		AKT serine/threonine kinase 1	EP300 lysine acetyltransferase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Spindle Cytosol Plasma Membrane Cell-cell Junction Cilium Cell Cortex Microtubule Cytoskeleton Membrane Lamellipodium Vesicle Protein-containing Complex Ciliary Basal Body Postsynapse Glutamatergic Synapse	Histone Acetyltransferase Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytoplasm Cytosol Protein-containing Complex Protein-DNA Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Kinase Activity Transferase Activity Enzyme Binding Kinase Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding 14-3-3 Protein Binding Potassium Channel Activator Activity Protein Serine Kinase Activity TORC2 Complex Binding	Transcription Coregulator Binding Transcription Coactivator Binding P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Beta-catenin Binding Zinc Ion Binding Histone H3 Acetyltransferase Activity Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Nuclear Receptor Binding Chromatin DNA Binding Histone H3K18 Acetyltransferase Activity Histone H2B Acetyltransferase Activity Histone H3K27 Acetyltransferase Activity Metal Ion Binding Tau Protein Binding Nuclear Androgen Receptor Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein-lysine-acetyltransferase Activity Protein Propionyltransferase Activity Pre-mRNA Intronic Binding STAT Family Protein Binding Peptide 2-hydroxyisobutyryltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Histone Lactyltransferase (CoA-dependent) Activity Acetylation-dependent Protein Binding Peptide Crotonyltransferase Activity Peptide Butyryltransferase Activity Histone Crotonyltransferase Activity Histone Butyryltransferase Activity DNA-binding Transcription Factor Binding Histone Reader Activity Histone H3K122 Acetyltransferase Activity
	Biological Process	Osteoblast Differentiation Maternal Placenta Development Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Cytoplasmic Translation Complement Receptor Mediated Signaling Pathway Sphingosine-1-phosphate Receptor Signaling Pathway Glycogen Metabolic Process Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Glucose Metabolic Process Gluconeogenesis Translational Initiation Regulation Of Translation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Nitric Oxide Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Response To Oxidative Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Germ Cell Development Nervous System Development Cell Population Proliferation Insulin Receptor Signaling Pathway Apoptotic Mitochondrial Changes Cellular Response To Starvation Response To Heat Response To Hormone Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Fibroblast Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Sodium Ion Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Neuron Projection Development Negative Regulation Of Macroautophagy Phosphorylation Cell Migration Protein Ubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Mammalian Oogenesis Stage Cell Differentiation Protein Catabolic Process Positive Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Costimulation Negative Regulation Of Protein Ubiquitination Regulation Of Myelination Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Endodeoxyribonuclease Activity Response To Food Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Stress Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Amino Acid Starvation Response To Fluid Shear Stress Protein K29-linked Ubiquitination Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Decreased Oxygen Levels SREBP-SCAP Complex Retention In Endoplasmic Reticulum TRNA Stabilization Calcium Import Into The Mitochondrion PERK-mediated Unfolded Protein Response TORC1 Signaling Glucose Homeostasis Regulation Of Apoptotic Process Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Anoikis Regulation Of MRNA Stability Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Cilium Assembly Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Nitric Oxide Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of Organ Growth Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Behavioral Response To Pain Positive Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Protein Maturation Excitatory Postsynaptic Potential Response To Growth Hormone Regulation Of Vesicle-mediated Transport Mammary Gland Epithelial Cell Differentiation Labyrinthine Layer Blood Vessel Development Protein Localization To Cilium Response To UV-A Response To Growth Factor Protein Localization To Endoplasmic Reticulum Protein K11-linked Ubiquitination Cellular Response To Calcium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Tricarboxylic Acid Metabolic Process Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Cellular Response To Rapamycin Protein K6-linked Ubiquitination Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Execution Phase Of Apoptosis Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Postsynapse Organization TRNA (guanine-N7)-methylation Regulation Of TRNA Methylation Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus CGAS/STING Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Negative Regulation Of CGAS/STING Signaling Pathway Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Cellular Response To Peptide Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cilium Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Maturation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Nerve Growth Factor Stimulus Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Lymphocyte Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Autophagosome Assembly Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Somitogenesis Thigmotaxis Behavioral Defense Response Stimulatory C-type Lectin Receptor Signaling Pathway Gluconeogenesis Glycolytic Process Regulation Of Glycolytic Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Protein Acetylation Internal Protein Amino Acid Acetylation Apoptotic Process Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Nervous System Development Heart Development Skeletal Muscle Tissue Development Learning Or Memory Circadian Rhythm Lipid Biosynthetic Process Animal Organ Morphogenesis Regulation Of Autophagy Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Positive Regulation Of Neuron Projection Development N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation B Cell Differentiation Platelet Formation Lung Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Protein Destabilization Cellular Response To Nutrient Levels Negative Regulation Of Protein Oligomerization Cellular Response To UV Multicellular Organism Growth Megakaryocyte Development Endodermal Cell Differentiation Swimming TORC1 Signaling TORC2 Signaling Positive Regulation Of Protein Import Into Nucleus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Estrogen Host-mediated Activation Of Viral Transcription Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Rhythmic Process Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Face Morphogenesis Regulation Of Androgen Receptor Signaling Pathway Peptidyl-lysine Propionylation Protein Localization To Chromatin Cellular Response To L-leucine Tricarboxylic Acid Metabolic Process T-helper 17 Cell Lineage Commitment Regulation Of Tubulin Deacetylation Peptidyl-lysine Crotonylation Peptidyl-lysine Butyrylation Regulation Of Cellular Response To Heat Positive Regulation Of Protein Localization To Nucleus Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation MTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Mitochondrial unfolded protein response (UPRmt) High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Regulation of gene expression by Hypoxia-inducible Factor Polo-like kinase mediated events Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors B-WICH complex positively regulates rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling Metalloprotease DUBs TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NGF-stimulated transcription NGF-stimulated transcription TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation STAT3 nuclear events downstream of ALK signaling Heme signaling SARS-CoV-1 targets host intracellular signalling and regulatory pathways Nuclear events mediated by NFE2L2 Formation of paraxial mesoderm NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Zygotic genome activation (ZGA) Evasion by RSV of host interferon responses TGFBR3 expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional and post-translational regulation of MITF-M expression and activity Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of PD-L1(CD274) transcription Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		ATP Arsenic trioxide Genistein Inositol 1,3,4,5-Tetrakisphosphate Resveratrol Archexin Enzastaurin Perifosine N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
Diseases		PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome	Rubinstein-Taybi syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) HDL cholesterol ( 24097068 25961943 30275531) HDL cholesterol levels ( 28334899 32203549) Neutrophil count ( 32888494) Vitamin C levels ( 33203707)	Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22936669) General risk tolerance (MTAG) ( 30643258) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 28991256 29483656) Type 2 diabetes ( 30297969)
Interacting Genes		396 interacting genes: ABI1 ABRAXAS1 ACAP1 ACAT2 AGAP2 AGR3 AHNAK AHSA1 AKT1S1 AKT2 AKTIP ALYREF AMBRA1 APLP2 APOE APOH APP APPL1 AR ARAF ARFIP2 ARHGAP9 ARHGEF16 ARHGEF28 ARNT ATXN1 AURKA BABAM1 BAD BAG6 BCL10 BCL2L1 BCL2L11 BCL3 BECN1 BEX1 BLVRA BPGM BRAF BRCA1 BTRC BUB1 C1orf174 CAMKK1 CARHSP1 CASC3 CASP3 CASP9 CASTOR1 CBLC CCDC88A CCND2 CCNE1 CCNF CCNI CCT2 CD44 CDC37 CDH1 CDK1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CEP57L1 CEP76 CGGBP1 CHEK1 CHUK CLASP2 CLIP3 CLK2 CMTM8 CNKSR3 CNOT9 CREB1 CREBBP CSNK2A1 CTDP1 CTDSP2 CTNNA1 CTNNB1 CYLD DAB2IP DCTN1 DDIT4L DLC1 DNAJB1 DNMT1 EEF1G EFHC1 EIF4EBP1 ELAVL1 EMSY ENO2 EP300 EPHA2 EPSTI1 ERBB2 ESR1 ESR2 EZH2 FAF1 FAM168A FANCA FANCI FASN FBXO31 FBXW7 FGFR4 FOXO1 FOXO3 FOXO4 FUS FXN GAB1 GAB2 GATA1 GATA2 GET4 GFAP GJA1 GLIS2 GMPPA GPT2 GRB10 GRIN2A GSK3A GSK3B H2BC21 H2BC3 HEATR3 HIF1A HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB IL13RA2 IL24 ILK IMPDH2 IRAK1 IRS1 ISCA2 ITCH ITGB3 ITPKB ITPR1 ITPR3 IWS1 JADE1 KANK1 KAT2A KAT2B KAT6A KDELR2 KLHL3 KLRC1 KMT2D KRT10 LANCL2 LATS2 LRRK2 LTB4R2 MAGEB1 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K11 MAP3K5 MAP3K8 MAPK4 MAPK8 MAPK8IP1 MAPK9 MAPKAP1 MAPKAPK2 MAPT MARK4 MATK MDM2 MDM4 MEF2D MESD METTL1 MLF2 MLH3 MOK MRC2 MS4A2 MSH2 MST1R MTA3 MTCP1 MTOR MTUS2 MUL1 MXD1 MYC NCF2 NCKIPSD NCOA4 NCOR2 NEDD4 NEDD4L NF1 NF2 NGB NHERF1 NIBAN1 NKD1 NLGN3 NOL4 NOS3 NOTCH1 NR4A1 NRAS NRIP2 NSD3 OFD1 OSBPL11 OSGIN1 OTUD1 OXSR1 PAK1 PCGF2 PCK1 PDE3A PDE3B PDGFRA PDHB PDK1 PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PFKP PHB2 PI4K2B PIAS1 PIAS2 PICK1 PIK3CA PIK3R1 PIP5K1C PKN2 PLCG1 PLEKHO1 PLP1 PLXNA1 PMS2 POP4 POP7 PPARGC1B PPL PPM1A PPM1H PPP1CA PPP1R11 PPP2CA PPP2R1A PRG2 PRKAR1A PRKCQ PRKCZ PRKDC PSMC5 PSRC1 PTEN PTGDS PTPA PTPN1 PTPN11 PTPN3 PYCR3 PYGO2 RAB3D RAC1 RAF1 RAP1GDS1 RARA RASL10B RASSF1 REPS1 REX1BD RGCC RHEBL1 RNF11 RNF115 RPS6KB1 RUVBL2 S100A14 S1PR1 SERPINB5 SETDB1 SFMBT2 SH2B2 SH3RF1 SHANK2 SHQ1 SIRPA SIRT1 SIRT6 SKI SKP2 SLFN5 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SNCB SORBS1 SORBS2 SOX4 SP1 SP3 SPACA6 SPATA33 SRC SRPK2 SRR SSH1 ST14 STAT1 STK11 STK3 STK4 STOX1 SULT4A1 SUPT6H SYTL1 TBC1D4 TBC1D7 TBCE TCL1A TCL1B TCL6 TEAD2 TERF2IP TERT TFF1 THEM4 THRSP TLR2 TMCC2 TNFRSF1A TNFSF11 TNK2 TOPBP1 TP53 TRAF6 TRIB3 TRIM13 TRIM24 TRIT1 TRMT2B TSC1 TSC2 TTC3 UBE2S UCHL1 UHRF1 URI1 USP10 USP4 USP50 UXS1 VEGFA VHL VIM WDR53 WEE1 WNK1 WNK4 XAF1 XIAP YAP1 YBX1 YIF1B YWHAZ ZC3HAV1 ZFP36L1 ZHX1 ZNF691 ZRANB1	375 interacting genes: ABL1 ACSM5 ACTA2 AHR AKT1 ALKBH4 ALX1 APEX1 AR ARHGDIA ARNT ARSF ASCL1 ASH2L ATF4 ATF5 ATR BAG6 BCAS2 BCL3 BCL6 BMAL1 BRCA1 BRMS1 C1R CALCOCO1 CARM1 CCNB1 CCND1 CDC25A CDK2 CDT1 CDX2 CEBPA CEBPB CEBPD CFH CHD4 CITED1 CITED2 CITED4 CLOCK CNOT4 COPS2 COPS6 CREBBP CRX CTBP1 CTBP2 CTF1 CTNNB1 CXCL8 CXXC1 DAO DBP DDIT3 DDX24 DECR2 DEK DTX1 DUX4 E2F1 E2F5 EEF1A1 EGR1 EID1 EID2 ELF3 ELK1 ELL EMB EPAS1 EPO ESR1 ESR2 ETS1 ETS2 ETV1 ETV4 EZH2 FBXL5 FEN1 FHL2 FOSB FOSL1 FOSL2 FOXO3 FOXP3 GAA GABPA GABPB1 GATA4 GATA5 GATA6 GCKR GLUL GOLGA2 GPBP1 GPS2 GRB2 GRIP1 GTF2B H1-1 H1-3 H2AC20 H2AC21 H2AC4 H2AC8 H2BC21 H2BC3 H3-3A H3-4 H3C1 H3C14 H4C1 H4C14 H4C16 H4C7 H4C9 HAND2 HBP1 HDAC1 HDAC3 HDAC6 HEMGN HERC1 HIF1A HMGB1 HMGN1 HMGN2 HNF1A HNRNPU HNRNPUL1 HOXA10 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD4 HPS6 HSP90AA2P ILF2 ILF3 IMMT ING1 ING2 ING4 ING5 IRF1 IRF2 IRF3 IRF5 IRF7 ITIH3 JDP2 JMY JUN JUNB JUND KAT2A KAT2B KAT5 KCTD5 KDM2A KLF1 KLF13 KLF2 KLF5 KPNA2 KRT18 LEF1 MAF MAGED1 MAML1 MAP2K1 MAP3K5 MAPK1 MAPK8 MAPT MAX MCM2 MCM3 MCM3AP MCM4 MCM5 MDC1 MDM2 MDM4 MEF2A MEF2C MEF2D MGMT MITF MLXIPL MN1 MORF4L1 MPG MRE11 MSH6 MSTO1 MTOR MYB MYBL2 MYC MYOD1 N4BP2 NAP1L1 NAP1L4 NBN NCOA1 NCOA2 NCOA3 NCOA6 NEDD1 NEDD4 NEIL2 NEUROD1 NFATC1 NFATC2 NFYA NFYB NOTCH1 NOXA1 NPAS2 NPM1 NR1H4 NR1I2 NR2F2 NR3C1 NR4A1 NUP98 NUPR1 OLIG2 ORC2 PAK2 PAX6 PAX8 PAXIP1 PCK2 PCNA PDHX PELP1 PIAS1 PIAS3 PIN1 PLAGL1 PLG PLSCR1 PLSCR2 PML POLB POLD2 POLI POU3F2 PPARA PPARD PPARG PPP2R5C PRKCA PRKCB PRKCD PRKDC PRMT1 PROX1 PTMA RACK1 RAD23A RAD50 RAN RB1 RBM14 RECQL4 REL RELA RORA RPL27 RPS6KA5 RPS6KB1 RPS6KB2 RUNX1 RUNX2 RUNX3 RUVBL2 SATB1 SAV1 SELENOP SENP3 SERTAD1 SET SETD1A SIK2 SIRT1 SIRT2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD7 SNIP1 SNW1 SOX9 SP1 SP3 SPHK1 SPIB SREBF1 SREBF2 SRY SS18 SS18L1 STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 SUB1 SUMO2 SUV39H1 TACC2 TADA3 TAF1B TAL1 TCF12 TCF3 TCF4 TCF7L2 TDG TERF2 TFAP2A TGFB1I1 TGS1 THPO TINAGL1 TNIP2 TP53 TP53BP1 TP63 TP73 TRAF2 TRERF1 TRIP4 TSG101 TWIST1 UBC UBE2D1 UBE2I UBQLN1 UBTF USF2 VPS18 WDR59 WDR82 XRCC6 YWHAZ YY1 ZBTB16 ZBTB17 ZBTB48 ZBTB49 ZBTB5 ZBTB7B ZBTB8A ZC3H12A ZEB1 ZFPM2 ZNF106 ZNF148 ZNF76 ZRANB2
Entrez ID		207	2033
HPRD ID		01261	04078
Ensembl ID		ENSG00000142208	ENSG00000100393
Uniprot IDs		B0LPE5 B3KVH4 P31749	A0A669KB12 Q09472 Q7Z6C1
PDB IDs		1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 5KCV 6BUU 6CCY 6HHF 6HHG 6HHH 6HHI 6HHJ 6NPZ 6S9W 6S9X 7APJ 7MYX 7NH4 7NH5 8JOW 8UVY 8UW2 8UW7 8UW9 8ZPU	1L3E 1P4Q 2K8F 2MH0 2MZD 3BIY 3I3J 3IO2 3P57 3T92 4BHW 4PZR 4PZS 4PZT 5BT3 5KJ2 5LKT 5LKU 5LKX 5LKZ 5LPK 5LPM 5NU5 5XZC 6DS6 6FGN 6FGS 6GYR 6GYT 6K4N 6PF1 6PGU 6V8B 6V8K 6V8N 6V90 7LJE 7QGS 7SS8 7SSK 7SZQ 7UGI 7VHY 7VHZ 7VI0 7W9V 7XEZ 7XFG 8E1D 8FVF 8GZC 8HAG 8HAH 8HAI 8HAJ 8HAK 9JEJ 9JUT
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Cytosol Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Stress Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Developmental Process Positive Regulation Of Protein Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Programmed Cell Death Negative Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Kinase Activity Cellular Response To Oxygen-containing Compound Regulation Of Cell Cycle Protein Kinase Activity Regulation Of Protein Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Protein Modification Process Regulation Of Phosphorus Metabolic Process MAPK Cascade Protein Serine Kinase Activity Protein Kinase Binding Regulation Of Protein Modification Process Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Regulation Of Developmental Process Transcription Regulator Complex Regulation Of Cell Differentiation Positive Regulation Of Developmental Process DNA-binding Transcription Factor Binding Chromatin Binding RNA Polymerase II Transcription Regulator Complex Chromatin Organization Cellular Response To Stress Regulation Of Cell Population Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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