AKT1 and MAP3K5

  • Number of citations of the paper that reports this interaction (PMID 11154276)
  • 144
  • Data Source:
  • BioGRID (affinity chromatography technology, enzymatic study)
  • HPRD (in vitro, in vivo)

AKT1

MAP3K5

Gene Name v-akt murine thymoma viral oncogene homolog 1 mitogen-activated protein kinase kinase kinase 5
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 191 interactors: ACAP1 AHNAK AKT1S1 AKT2 AKTIP ALYREF APLP2 APOH APP APPL1 AR ARFIP2 ARHGAP29 ARHGAP32 ATXN1 BAD BCL10 BCL2L1 BCL2L11 BPGM BRAF BRCA1 CAMKK1 CARHSP1 CASP3 CASP9 CCDC88A CDKN1A CDKN1B CDKN1C CHEK1 CHN2 CHUK CLIP3 CLK2 CREB1 CREBBP CSNK2A1 CTNNB1 CYLD DAB2IP DCTN1 DLC1 DNAJB1 DNMT1 EEF1G EIF4EBP1 EP300 ESR1 ESR2 EZH2 FANCA FOXO1 FOXO3 FOXO4 GAB2 GATA1 GATA2 GRB10 GSK3A GSK3B HIST2H2BE HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB ILK IMPDH2 IRAK1 IRS1 ITGB3 ITPR1 ITPR3 JADE1 KAT2B KAT6A KRT10 KTN1 LRRK2 MAP2K4 MAP3K11 MAP3K5 MAP3K8 MAPK14 MAPK8IP1 MAPKAPK2 MAPT MDM2 MDM4 METTL1 MS4A2 MST1R MTCP1 MTOR MUL1 MXD1 NCOA4 NCOR2 NF2 NOS3 NOTCH1 NR4A1 PAK1 PAK6 PDE3B PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PHB2 PI4K2B PIAS1 PIAS2 PIK3R1 PKN2 PLCG1 PLEKHO1 PLXNA1 PPARGC1B PPL PPM1A PPP1CA PPP2CA PPP2R1A PPP2R4 PRG2 PRKCQ PRKCZ PRKDC PTEN PTPN1 RAB3D RAC1 RAF1 RARA RGCC RHEBL1 RICTOR RNF11 RNF115 RPS6KB1 RQCD1 S1PR1 SETDB1 SH2B2 SH3RF1 SIRT1 SIRT6 SKI SKP2 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SORBS2 SORBS3 SRC STAT1 STK3 STK4 TBC1D4 TCL1A TCL1B TCL6 TERF2IP TERT THEM4 TNFSF11 TOPBP1 TRIB3 TSC1 TSC2 TTC3 USP4 UXS1 VEGFA VIM WNK1 WNK4 XIAP YAP1 YBX1 YWHAZ ZFP36L1 ZHX1 50 interactors: AKT1 AKT2 ARRB1 ARRB2 CDC25A CDKN1A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 GADD45B GEMIN5 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L PDCD6 PPP3R1 PPP5C PTPN11 QARS RAF1 SFN TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID 207 4217
HPRD ID 01261 03904
Ensembl ID ENSG00000142208 ENSG00000197442
Uniprot IDs B0LPE5 B3KVH4 P31749 Q99683
PDB IDs 1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
advance  catenin  contributes  decreasing  deregulation  doi  dramatically  foxo1  glioma  gliomas  implicate  inducing  insights  introduction  invasion  january  micrornas  mir  mirnas  onc  oncogene  online  phosphorylated  publication  silencing  suppressed  tissues  tumorigenesis  unfavorable 
199a2  angptl2  awry  chondrosarcoma  cmet  discovering  dnm3  evenly  fibrosarcoma  flt1  flt4  foxl1  genetics  gli1  hif1alpha  hmga2  kdr  liposarcoma  mdk  med12  muc4  mycn  osteocytes  pcsk1  relentless  sarcoma  tek  tie1  yeats4 
Tagcloud (Difference) ?
advance  catenin  contributes  decreasing  deregulation  doi  dramatically  foxo1  glioma  gliomas  implicate  inducing  insights  introduction  invasion  january  micrornas  mir  mirnas  onc  oncogene  online  phosphorylated  publication  silencing  suppressed  tissues  tumorigenesis  unfavorable 
199a2  angptl2  awry  chondrosarcoma  cmet  discovering  dnm3  evenly  fibrosarcoma  flt1  flt4  foxl1  genetics  gli1  hif1alpha  hmga2  kdr  liposarcoma  mdk  med12  muc4  mycn  osteocytes  pcsk1  relentless  sarcoma  tek  tie1  yeats4 
Tagcloud (Intersection) ?