AKT1 and CDKN1A

Number of citations of the paper that reports this interaction (PubMedID 16982699)
51

Data Source:
BioGRID (pull down, enzymatic study, imaging technique, enzymatic study)
HPRD (in vivo, in vitro)

		AKT1	CDKN1A
Description		AKT serine/threonine kinase 1	cyclin dependent kinase inhibitor 1A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Endoplasmic Reticulum Spindle Cytosol Plasma Membrane Cell-cell Junction Cilium Cell Cortex Microtubule Cytoskeleton Membrane Lamellipodium Vesicle Protein-containing Complex Ciliary Basal Body Postsynapse Glutamatergic Synapse	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Body Protein-containing Complex PCNA-p21 Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Kinase Activity Transferase Activity Enzyme Binding Kinase Binding Protein Kinase Binding Nitric-oxide Synthase Regulator Activity Protein Serine/threonine Kinase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding 14-3-3 Protein Binding Potassium Channel Activator Activity Protein Serine Kinase Activity TORC2 Complex Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Metal Ion Binding Protein Serine/threonine Kinase Binding Protein Sequestering Activity Molecular Function Activator Activity Molecular Function Inhibitor Activity
	Biological Process	Osteoblast Differentiation Maternal Placenta Development Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Cytoplasmic Translation Complement Receptor Mediated Signaling Pathway Sphingosine-1-phosphate Receptor Signaling Pathway Glycogen Metabolic Process Glycogen Biosynthetic Process Regulation Of Glycogen Biosynthetic Process Glucose Metabolic Process Gluconeogenesis Translational Initiation Regulation Of Translation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Nitric Oxide Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Response To Oxidative Stress Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Germ Cell Development Nervous System Development Cell Population Proliferation Insulin Receptor Signaling Pathway Apoptotic Mitochondrial Changes Cellular Response To Starvation Response To Heat Response To Hormone Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Fibroblast Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Sodium Ion Transport Positive Regulation Of Glucose Metabolic Process Regulation Of Neuron Projection Development Negative Regulation Of Macroautophagy Phosphorylation Cell Migration Protein Ubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Mammalian Oogenesis Stage Cell Differentiation Protein Catabolic Process Positive Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Costimulation Negative Regulation Of Protein Ubiquitination Regulation Of Myelination Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Nutrient Levels TOR Signaling Negative Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Endodeoxyribonuclease Activity Response To Food Peripheral Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Regulation Of Protein Localization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Stress Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Amino Acid Starvation Response To Fluid Shear Stress Protein K29-linked Ubiquitination Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Cellular Response To Decreased Oxygen Levels SREBP-SCAP Complex Retention In Endoplasmic Reticulum TRNA Stabilization Calcium Import Into The Mitochondrion PERK-mediated Unfolded Protein Response TORC1 Signaling Glucose Homeostasis Regulation Of Apoptotic Process Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Anoikis Regulation Of MRNA Stability Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Cilium Assembly Positive Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Nitric Oxide Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of Organ Growth Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Behavioral Response To Pain Positive Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Protein Metabolic Process Protein Maturation Excitatory Postsynaptic Potential Response To Growth Hormone Regulation Of Vesicle-mediated Transport Mammary Gland Epithelial Cell Differentiation Labyrinthine Layer Blood Vessel Development Protein Localization To Cilium Response To UV-A Response To Growth Factor Protein Localization To Endoplasmic Reticulum Protein K11-linked Ubiquitination Cellular Response To Calcium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Prostaglandin E Stimulus Tricarboxylic Acid Metabolic Process Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Cellular Response To Rapamycin Protein K6-linked Ubiquitination Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Execution Phase Of Apoptosis Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Postsynapse Organization TRNA (guanine-N7)-methylation Regulation Of TRNA Methylation Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus CGAS/STING Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Negative Regulation Of CGAS/STING Signaling Pathway Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Nucleus Cellular Response To Peptide Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Cilium Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Maturation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of TORC2 Signaling Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Nerve Growth Factor Stimulus Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Lymphocyte Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Protein Import Into Nucleus DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Epidermis Development Response To UV Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Keratinocyte Differentiation Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of B Cell Proliferation Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To Amino Acid Starvation Wound Healing Tissue Regeneration Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Programmed Cell Death Keratinocyte Proliferation Positive Regulation Of DNA Replication Positive Regulation Of Protein Kinase Activity Negative Regulation Of Growth Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Import Into Nucleus Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To UV-B Signal Transduction By P53 Class Mediator Cellular Senescence Replicative Senescence Stress-induced Premature Senescence Oncogene-induced Cell Senescence Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation MTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Mitochondrial unfolded protein response (UPRmt) High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Neddylation Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by ALK fusions and activated point mutants KEAP1-NFE2L2 pathway Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs		ATP Arsenic trioxide Genistein Inositol 1,3,4,5-Tetrakisphosphate Resveratrol Archexin Enzastaurin Perifosine N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine	Valproic acid Arsenic trioxide
Diseases		PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome	Cervical cancer
GWAS		Apolipoprotein A1 levels ( 32203549) Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) HDL cholesterol ( 24097068 25961943 30275531) HDL cholesterol levels ( 28334899 32203549) Neutrophil count ( 32888494) Vitamin C levels ( 33203707)	Abdominal aortic aneurysm ( 32981348) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874 33547301) Atrial fibrillation ( 30061737 29892015) Colorectal cancer ( 30529582 31826910 22634755) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic conduction measures ( 23463857) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 29891935) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495597 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) JT interval ( 29874175) Left ventricle wall thickness ( 33495596) Left ventricular fractional shortening ( 28394258) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) QRS complex (Cornell) ( 27659466) QRS duration ( 31251759 31217584 30679814 27659466 27577874 25035420 21076409) Triglyceride levels ( 32203549) Triglycerides ( 27036123)
Interacting Genes		396 interacting genes: ABI1 ABRAXAS1 ACAP1 ACAT2 AGAP2 AGR3 AHNAK AHSA1 AKT1S1 AKT2 AKTIP ALYREF AMBRA1 APLP2 APOE APOH APP APPL1 AR ARAF ARFIP2 ARHGAP9 ARHGEF16 ARHGEF28 ARNT ATXN1 AURKA BABAM1 BAD BAG6 BCL10 BCL2L1 BCL2L11 BCL3 BECN1 BEX1 BLVRA BPGM BRAF BRCA1 BTRC BUB1 C1orf174 CAMKK1 CARHSP1 CASC3 CASP3 CASP9 CASTOR1 CBLC CCDC88A CCND2 CCNE1 CCNF CCNI CCT2 CD44 CDC37 CDH1 CDK1 CDK4 CDK6 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CEP57L1 CEP76 CGGBP1 CHEK1 CHUK CLASP2 CLIP3 CLK2 CMTM8 CNKSR3 CNOT9 CREB1 CREBBP CSNK2A1 CTDP1 CTDSP2 CTNNA1 CTNNB1 CYLD DAB2IP DCTN1 DDIT4L DLC1 DNAJB1 DNMT1 EEF1G EFHC1 EIF4EBP1 ELAVL1 EMSY ENO2 EP300 EPHA2 EPSTI1 ERBB2 ESR1 ESR2 EZH2 FAF1 FAM168A FANCA FANCI FASN FBXO31 FBXW7 FGFR4 FOXO1 FOXO3 FOXO4 FUS FXN GAB1 GAB2 GATA1 GATA2 GET4 GFAP GJA1 GLIS2 GMPPA GPT2 GRB10 GRIN2A GSK3A GSK3B H2BC21 H2BC3 HEATR3 HIF1A HMOX1 HSP90AA1 HSP90AB1 HSPB1 HTT IKBKB IL13RA2 IL24 ILK IMPDH2 IRAK1 IRS1 ISCA2 ITCH ITGB3 ITPKB ITPR1 ITPR3 IWS1 JADE1 KANK1 KAT2A KAT2B KAT6A KDELR2 KLHL3 KLRC1 KMT2D KRT10 LANCL2 LATS2 LRRK2 LTB4R2 MAGEB1 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K11 MAP3K5 MAP3K8 MAPK4 MAPK8 MAPK8IP1 MAPK9 MAPKAP1 MAPKAPK2 MAPT MARK4 MATK MDM2 MDM4 MEF2D MESD METTL1 MLF2 MLH3 MOK MRC2 MS4A2 MSH2 MST1R MTA3 MTCP1 MTOR MTUS2 MUL1 MXD1 MYC NCF2 NCKIPSD NCOA4 NCOR2 NEDD4 NEDD4L NF1 NF2 NGB NHERF1 NIBAN1 NKD1 NLGN3 NOL4 NOS3 NOTCH1 NR4A1 NRAS NRIP2 NSD3 OFD1 OSBPL11 OSGIN1 OTUD1 OXSR1 PAK1 PCGF2 PCK1 PDE3A PDE3B PDGFRA PDHB PDK1 PDK2 PDPK1 PEA15 PFKFB1 PFKFB2 PFKP PHB2 PI4K2B PIAS1 PIAS2 PICK1 PIK3CA PIK3R1 PIP5K1C PKN2 PLCG1 PLEKHO1 PLP1 PLXNA1 PMS2 POP4 POP7 PPARGC1B PPL PPM1A PPM1H PPP1CA PPP1R11 PPP2CA PPP2R1A PRG2 PRKAR1A PRKCQ PRKCZ PRKDC PSMC5 PSRC1 PTEN PTGDS PTPA PTPN1 PTPN11 PTPN3 PYCR3 PYGO2 RAB3D RAC1 RAF1 RAP1GDS1 RARA RASL10B RASSF1 REPS1 REX1BD RGCC RHEBL1 RNF11 RNF115 RPS6KB1 RUVBL2 S100A14 S1PR1 SERPINB5 SETDB1 SFMBT2 SH2B2 SH3RF1 SHANK2 SHQ1 SIRPA SIRT1 SIRT6 SKI SKP2 SLFN5 SMAD2 SMAD3 SMAD4 SMAD7 SMARCB1 SMARCC1 SNCA SNCB SORBS1 SORBS2 SOX4 SP1 SP3 SPACA6 SPATA33 SRC SRPK2 SRR SSH1 ST14 STAT1 STK11 STK3 STK4 STOX1 SULT4A1 SUPT6H SYTL1 TBC1D4 TBC1D7 TBCE TCL1A TCL1B TCL6 TEAD2 TERF2IP TERT TFF1 THEM4 THRSP TLR2 TMCC2 TNFRSF1A TNFSF11 TNK2 TOPBP1 TP53 TRAF6 TRIB3 TRIM13 TRIM24 TRIT1 TRMT2B TSC1 TSC2 TTC3 UBE2S UCHL1 UHRF1 URI1 USP10 USP4 USP50 UXS1 VEGFA VHL VIM WDR53 WEE1 WNK1 WNK4 XAF1 XIAP YAP1 YBX1 YIF1B YWHAZ ZC3HAV1 ZFP36L1 ZHX1 ZNF691 ZRANB1	207 interacting genes: A1BG A2M ABL1 ACTB ACTL6B ADAMTS10 AKT1 AKT2 ALAS1 ANGPT2 APLP1 APP ATP5F1B ATP6V1A ATXN3 BAD BAG6 BCCIP CASP3 CCDC85B CCN3 CCNA1 CCNA2 CCNB1 CCNB2 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCT7 CDC45 CDC5L CDC6 CDC7 CDK1 CDK14 CDK2 CDK3 CDK4 CDK6 CEBPA CELF3 CENPB CHEK2 CHGB CIZ1 CLEC3B COL4A5 COPS6 CPNE2 CPNE6 CSAD CSNK2A1 CSNK2B CTSB CZIB DAPK3 DCAF11 DDAH2 DEAF1 DOCK7 DTL DYNC1I1 EEF1A1 ESR1 EXT2 F13A1 FAF1 FBN3 FGB FHL3 FLAD1 FNDC11 GADD45A GADD45B GADD45G GAPDH GCKR GDF9 GET4 GMNN GNB2 GNB5 GOLGA2 H1-5 HADHB HDAC1 HDAC11 HDAC2 HDAC4 HDAC6 HERC5 HMGXB3 HNRNPK HOOK2 HOXD8 HPD IKBKG IKZF3 INCA1 ING5 INPP5K KIFC3 KLHL23 KMT2B KRT31 KRTAP3-1 LATS2 LRIF1 LRP2BP LRR1 LZTS2 MAP3K5 MAPK8 MCM10 MED31 MEOX2 MSH2 MTUS2 NFYA NGFR NKD2 NMRK2 NPRL2 NR1H2 NRBP1 NSUN2 OTUB1 PARP1 PCNA PDE4DIP PDHB PIM1 POLD2 PPM1D PRKACA PRKAR1B PRKN PSMA3 PSMC2 QARS1 RAB1A RACK1 RAI1 RANBP9 RB1 RBBP4 RBM48 REL RNF144B RPL18 RPL35 RPS2 RRM2B S100A8 SCML2 SDF4 SET SETDB1 SHISA6 SIPA1 SKP1 SLC25A11 SP110 SPRED1 STAT3 STAT5B STUB1 SUMO3 TAF5L TCF4 TEX11 TFIP11 TK1 TLE1 TMSB4X TNIP1 TNIP2 TNKS TRAF1 TRIM21 TRIM3 TRIM54 TRIM71 TRMT2A TSG101 TTLL5 TUBA1A TUBB2B TUBB3 TXN TXNDC11 UBE2D1 UNC119 USHBP1 USP4 VIM VPS51 WDR73 WIZ XRCC6 YWHAQ ZBTB16 ZBTB48 ZNF135 ZNF431
Entrez ID		207	1026
HPRD ID		01261	00298
Ensembl ID		ENSG00000142208	ENSG00000124762
Uniprot IDs		B0LPE5 B3KVH4 P31749	P38936
PDB IDs		1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 5KCV 6BUU 6CCY 6HHF 6HHG 6HHH 6HHI 6HHJ 6NPZ 6S9W 6S9X 7APJ 7MYX 7NH4 7NH5 8JOW 8UVY 8UW2 8UW7 8UW9 8ZPU	1AXC 2ZVV 2ZVW 4RJF 5E0U 6CBI 6CEJ 6CIV 6CIX 6P8H 7KQ0 7KQ1 8GJF
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Signal Transduction Cytosol Regulation Of Signaling Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Cytoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Stress Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Developmental Process Positive Regulation Of Protein Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Programmed Cell Death Negative Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Kinase Activity Cellular Response To Oxygen-containing Compound Regulation Of Cell Cycle Protein Kinase Activity Regulation Of Protein Stability Cell Surface Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Protein Modification Process Regulation Of Phosphorus Metabolic Process MAPK Cascade Protein Serine Kinase Activity Protein Kinase Binding Regulation Of Protein Modification Process Regulation Of Apoptotic Signaling Pathway	Nucleus Nucleoplasm Regulation Of Primary Metabolic Process Cytoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Cyclin Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Cytosol Regulation Of Programmed Cell Death Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Macromolecule Metabolic Process Regulation Of Cell Cycle Phase Transition Cell Division Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Signal Transduction Cellular Response To Stress Negative Regulation Of Intracellular Signal Transduction Protein Binding Regulation Of Macromolecule Biosynthetic Process Protein Kinase Binding Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Biosynthetic Process Positive Regulation Of Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Fibroblast Proliferation Negative Regulation Of Signaling Negative Regulation Of Cell Communication
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