LTF and LRP1

Number of citations of the paper that reports this interaction (PubMedID 1464627)
0

Data Source:
HPRD (in vivo)

		LTF	LRP1
Description		lactotransferrin	LDL receptor related protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Early Endosome Plasma Membrane Cell Surface Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Recycling Endosome Extracellular Exosome Phagocytic Vesicle Lumen Tertiary Granule Lumen	Nucleus Nucleolus Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Endocytic Vesicle Membrane Receptor Complex Plasma Membrane Protein Complex
	Molecular Function	Lipopolysaccharide Binding DNA Binding Serine-type Endopeptidase Activity Cysteine-type Endopeptidase Inhibitor Activity Iron Ion Binding Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Membrane Destabilizing Activity	Amyloid-beta Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Lipoprotein Particle Receptor Binding
	Biological Process	Ossification Regulation Of Cytokine Production Innate Immune Response In Mucosa Immune System Process Proteolysis Monoatomic Ion Transport Iron Ion Transport Humoral Immune Response Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Another Organism Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of ATP-dependent Activity Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Proces Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Membrane Potential Negative Regulation Of Viral Process Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Cytolysis By Host Of Symbiont Cells Bone Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Osteoclast Development	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Lipid Transport Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Transport Apoptotic Cell Clearance Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Transport Regulation Of Protein Metabolic Process Negative Regulation Of SMAD Protein Signal Transduction Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Transport Across Blood-brain Barrier Positive Regulation Of Amyloid-beta Clearance Regulation Of Extracellular Matrix Organization Positive Regulation Of Reverse Cholesterol Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Mtb iron assimilation by chelation Neutrophil degranulation Metal sequestration by antimicrobial proteins Antimicrobial peptides Amyloid fiber formation	Scavenging of heme from plasma Retinoid metabolism and transport
Drugs		3h-Indole-5,6-Diol Lauric acid Nitrilotriacetic acid alpha-D-Fucopyranose Nimesulide (R)-Atenolol Parecoxib	Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Von Willebrand factor human Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		AIDS progression ( 21502085) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Early-onset schizophrenia ( 33907183) Inflammatory bowel disease ( 26192919) Macular thickness ( 30535121) Ulcerative colitis ( 26192919)	Abdominal aortic aneurysm ( 22055160 27899403) Adult asthma ( 30787307) Appendicular lean mass ( 33097823) Asthma ( 31959851 31619474 29273806 27182965) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28552196) Cervical artery dissection ( 25420145) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899) Headache ( 29397368) Height ( 31562340) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27322543 22683712 21666692 23793025 27182965) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Moyamoya disease ( 29273593) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Spontaneous coronary artery dissection ( 32374345 32887874) Triglyceride levels ( 28334899) Triglycerides ( 25961943 24097068 20686565)
Interacting Genes		13 interacting genes: ACE2 CALM1 CD14 CEL CP EPPIN ITLN1 LCN1 LRP1 LYZ MUC7 UBC USP7	74 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 BDNF C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CLU CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90AA1 HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NGF NOS1AP NTF3 NTF4 PDGFB PID1 PLAT PLAUR PRKACA PTPN11 RBM11 RIC8B RNF10 SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		4057	4035
HPRD ID		01028	00138
Ensembl ID		ENSG00000012223	ENSG00000123384
Uniprot IDs		B3KSL2 E7ER44 P02788 Q2TUW9 V9HWI4	Q07954 Q59FG2
PDB IDs		1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS 7JRD 7N88	1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endocytic Vesicle Membrane Extracellular Exosome Regulation Of Transport Endocytosis Receptor-mediated Endocytosis Negative Regulation Of Calcium Ion Transport Membrane Raft Opsonin Receptor Activity Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Brush Border Membrane Import Into Cell Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Other Organism Diterpenoid Metabolic Process Retinoid Metabolic Process Acetylesterase Activity Oxidoreductase Activity, Acting On Metal Ions Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Regulation Of Cardiac Muscle Contraction Phagocytosis Cellular Response To Triacyl Bacterial Lipopeptide Response To External Biotic Stimulus Terpenoid Metabolic Process Ceramide Metabolic Process Ferroxidase Activity Lipoprotein Particle Receptor Binding Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Flagellated Sperm Motility Entry Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction Lipopolysaccharide Receptor Complex Positive Regulation Of Transport Peptidoglycan Immune Receptor Activity Sterol Ester Esterase Activity Isoprenoid Metabolic Process Phospholipid-hydroperoxide Glutathione Peroxidase Activity Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Viral Translation	Signaling Receptor Binding Extracellular Space Extracellular Region Low-density Lipoprotein Particle Receptor Binding Endoplasmic Reticulum Lumen Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Extracellular Matrix Heparin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Golgi Lumen Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Processing Regulation Of Protein Metabolic Process Cell Projection Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Protein Maturation Cell Surface Platelet Alpha Granule Lumen Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Nerve Growth Factor Receptor Binding Regulation Of Vesicle-mediated Transport Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor-mediated Endocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Amyloid-beta Binding Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Perinuclear Region Of Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Transport Positive Regulation Of MAPK Cascade
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