LTF and ITLN1

Number of citations of the paper that reports this interaction (PubMedID 11313366)
0

Data Source:
HPRD (in vitro)

		LTF	ITLN1
Description		lactotransferrin	intelectin 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Early Endosome Plasma Membrane Cell Surface Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Recycling Endosome Extracellular Exosome Phagocytic Vesicle Lumen Tertiary Granule Lumen	Extracellular Region Extracellular Space Plasma Membrane Membrane Brush Border Membrane Receptor Complex Membrane Raft Extracellular Exosome Side Of Membrane
	Molecular Function	Lipopolysaccharide Binding DNA Binding Serine-type Endopeptidase Activity Cysteine-type Endopeptidase Inhibitor Activity Iron Ion Binding Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Membrane Destabilizing Activity	Calcium Ion Binding Protein Binding Carbohydrate Binding Identical Protein Binding Metal Ion Binding Oligosaccharide Binding
	Biological Process	Ossification Regulation Of Cytokine Production Innate Immune Response In Mucosa Immune System Process Proteolysis Monoatomic Ion Transport Iron Ion Transport Humoral Immune Response Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Another Organism Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of ATP-dependent Activity Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Proces Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Membrane Potential Negative Regulation Of Viral Process Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Cytolysis By Host Of Symbiont Cells Bone Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Osteoclast Development	Positive Regulation Of Protein Phosphorylation Response To Nematode Positive Regulation Of D-glucose Import Protein Homotrimerization
Pathways		Mtb iron assimilation by chelation Neutrophil degranulation Metal sequestration by antimicrobial proteins Antimicrobial peptides Amyloid fiber formation	Antimicrobial peptides
Drugs		3h-Indole-5,6-Diol Lauric acid Nitrilotriacetic acid alpha-D-Fucopyranose Nimesulide (R)-Atenolol Parecoxib
Diseases
GWAS		AIDS progression ( 21502085) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Early-onset schizophrenia ( 33907183) Inflammatory bowel disease ( 26192919) Macular thickness ( 30535121) Ulcerative colitis ( 26192919)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 21102463 28067908) Inflammatory bowel disease ( 23128233 28067908)
Interacting Genes		13 interacting genes: ACE2 CALM1 CD14 CEL CP EPPIN ITLN1 LCN1 LRP1 LYZ MUC7 UBC USP7	1 interacting genes: LTF
Entrez ID		4057	55600
HPRD ID		01028	17165
Ensembl ID		ENSG00000012223	ENSG00000179914
Uniprot IDs		B3KSL2 E7ER44 P02788 Q2TUW9 V9HWI4	Q8WWA0
PDB IDs		1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS 7JRD 7N88	4WMQ 4WMY 6USC
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endocytic Vesicle Membrane Extracellular Exosome Regulation Of Transport Endocytosis Receptor-mediated Endocytosis Negative Regulation Of Calcium Ion Transport Membrane Raft Opsonin Receptor Activity Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Brush Border Membrane Import Into Cell Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Other Organism Diterpenoid Metabolic Process Retinoid Metabolic Process Acetylesterase Activity Oxidoreductase Activity, Acting On Metal Ions Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Regulation Of Cardiac Muscle Contraction Phagocytosis Cellular Response To Triacyl Bacterial Lipopeptide Response To External Biotic Stimulus Terpenoid Metabolic Process Ceramide Metabolic Process Ferroxidase Activity Lipoprotein Particle Receptor Binding Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Flagellated Sperm Motility Entry Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction Lipopolysaccharide Receptor Complex Positive Regulation Of Transport Peptidoglycan Immune Receptor Activity Sterol Ester Esterase Activity Isoprenoid Metabolic Process Phospholipid-hydroperoxide Glutathione Peroxidase Activity Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Viral Translation	Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Positive Regulation Of Bone Mineralization Involved In Bone Maturation Phagocytic Vesicle Lumen Membrane Destabilizing Activity Negative Regulation Of Osteoclast Development Negative Regulation Of ATP-dependent Activity Cytolysis By Host Of Symbiont Cells Negative Regulation Of Membrane Potential Specific Granule Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Antifungal Humoral Response Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Osteoclast Development Positive Regulation Of Chondrocyte Proliferation Positive Regulation Of Osteoblast Proliferation Host-mediated Suppression Of Viral Proces Innate Immune Response In Mucosa Cysteine-type Endopeptidase Inhibitor Activity Lipopolysaccharide Binding Bone Morphogenesis Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Osteoblast Proliferation Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of ATP-dependent Activity Biological Process Involved In Interaction With Symbiont Mucosal Immune Response Negative Regulation Of Osteoclast Differentiation Killing By Host Of Symbiont Cells Organ Or Tissue Specific Immune Response Positive Regulation Of Bone Mineralization Iron Ion Transport Tertiary Granule Lumen Defense Response To Fungus Positive Regulation Of Ossification Negative Regulation Of Viral Genome Replication Positive Regulation Of Biomineral Tissue Development Negative Regulation Of Myeloid Leukocyte Differentiation Specific Granule Lumen Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Fungus Antibacterial Humoral Response Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Osteoclast Differentiation Protein Serine/threonine Kinase Activator Activity Regulation Of Viral Genome Replication Positive Regulation Of Osteoblast Differentiation Host-mediated Perturbation Of Viral Process Regulation Of Bone Mineralization
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