LTF and MUC7

Number of citations: 0 (PubMedID 12766201)
Data Source: HPRD (in vitro, in vivo)

		LTF	MUC7
Name		lactotransferrin	mucin 7, secreted
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Early Endosome Plasma Membrane Cell Surface Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Recycling Endosome Extracellular Exosome Phagocytic Vesicle Lumen Tertiary Granule Lumen	Extracellular Region Golgi Lumen Plasma Membrane Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding DNA Binding Serine-type Endopeptidase Activity Cysteine-type Endopeptidase Inhibitor Activity Iron Ion Binding Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Membrane Destabilizing Activity	Protein Binding
	Biological Process	Ossification Regulation Of Cytokine Production Innate Immune Response In Mucosa Immune System Process Proteolysis Monoatomic Ion Transport Iron Ion Transport Humoral Immune Response Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Another Organism Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of ATP-dependent Activity Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Proces Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Membrane Potential Negative Regulation Of Viral Process Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Cytolysis By Host Of Symbiont Cells Bone Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Osteoclast Development	Killing Of Cells Of Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Mtb iron assimilation by chelation Neutrophil degranulation Metal sequestration by antimicrobial proteins Antimicrobial peptides Amyloid fiber formation	Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs		3h-Indole-5,6-Diol Lauric acid Nitrilotriacetic acid alpha-D-Fucopyranose Nimesulide (R)-Atenolol Parecoxib	None
GWAS		AIDS progression ( 21502085 ) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798 ) Early-onset schizophrenia ( 33907183 ) Inflammatory bowel disease ( 26192919 ) Macular thickness ( 30535121 ) Ulcerative colitis ( 26192919 )	Diabetic nephropathy in type 1 diabetes ( 31537649 )
Interacting Genes		13 interacting genes: ACE2 CALM1 CD14 CEL CP EPPIN ITLN1 LCN1 LRP1 LYZ MUC7 UBC USP7	8 interacting genes: AMY1A GALNT10 GALNT12 GALNT14 HTN3 LTF PCGF1 SELL
Entrez ID		4057	4589
HPRD ID		01028	11759
Ensembl ID		ENSG00000012223	ENSG00000171195
Uniprot IDs		B3KSL2 E7ER44 P02788 Q2TUW9 V9HWI4	Q8TAX7
PDB IDs		1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS 7JRD 7N88	Not available
GO Terms Enriched among Interactors		Extracellular Region Extracellular Space Endocytic Vesicle Membrane Extracellular Exosome Regulation Of Transport Endocytosis Receptor-mediated Endocytosis Negative Regulation Of Calcium Ion Transport Membrane Raft Opsonin Receptor Activity Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Brush Border Membrane Import Into Cell Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Other Organism Diterpenoid Metabolic Process Retinoid Metabolic Process Acetylesterase Activity Oxidoreductase Activity, Acting On Metal Ions Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Regulation Of Cardiac Muscle Contraction Phagocytosis Cellular Response To Triacyl Bacterial Lipopeptide Response To External Biotic Stimulus Terpenoid Metabolic Process Ceramide Metabolic Process Ferroxidase Activity Lipoprotein Particle Receptor Binding Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Flagellated Sperm Motility Entry Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction Lipopolysaccharide Receptor Complex Positive Regulation Of Transport Peptidoglycan Immune Receptor Activity Sterol Ester Esterase Activity Isoprenoid Metabolic Process Phospholipid-hydroperoxide Glutathione Peroxidase Activity Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Viral Translation	Polypeptide N-acetylgalactosaminyltransferase Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Carbohydrate Binding Metal Ion Binding Protein O-linked Glycosylation Protein Glycosylation Macromolecule Glycosylation Glycosylation Glycosyltransferase Activity Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Defense Response To Fungus Response To Fungus Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Alpha-amylase Activity Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Carbohydrate Derivative Biosynthetic Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Killing Of Cells Of Another Organism Positive Regulation Of Bone Mineralization Involved In Bone Maturation Phagocytic Vesicle Lumen Membrane Destabilizing Activity Antimicrobial Humoral Response Heparin Binding Negative Regulation Of Osteoclast Development Golgi Membrane Extracellular Space Glycosphingolipid Binding Cell Killing Positive Regulation Of Chondrocyte Proliferation Regulation Of Osteoclast Development Carbohydrate Derivative Metabolic Process Cytolysis By Host Of Symbiont Cells Antifungal Humoral Response Chloride Ion Binding Humoral Immune Response Negative Regulation Of ATP-dependent Activity Negative Regulation Of Membrane Potential Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Osteoblast Proliferation Oligosaccharide Binding Specific Granule Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cation Binding Host-mediated Suppression Of Viral Proces Defense Response To Bacterium