LTF and EPPIN

Number of citations of the paper that reports this interaction (PubMedID 17567961)
0

Data Source:
BioGRID (far western blotting)

		LTF	EPPIN
Description		lactotransferrin	epididymal peptidase inhibitor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Early Endosome Plasma Membrane Cell Surface Secretory Granule Protein-containing Complex Specific Granule Lumen Specific Granule Recycling Endosome Extracellular Exosome Phagocytic Vesicle Lumen Tertiary Granule Lumen	Acrosomal Vesicle Extracellular Region Extracellular Space Cytoplasm Cell Surface Protein-containing Complex Sperm Plasma Membrane
	Molecular Function	Lipopolysaccharide Binding DNA Binding Serine-type Endopeptidase Activity Cysteine-type Endopeptidase Inhibitor Activity Iron Ion Binding Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Membrane Destabilizing Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Ossification Regulation Of Cytokine Production Innate Immune Response In Mucosa Immune System Process Proteolysis Monoatomic Ion Transport Iron Ion Transport Humoral Immune Response Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Another Organism Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of ATP-dependent Activity Positive Regulation Of Osteoblast Proliferation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Proces Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Membrane Potential Negative Regulation Of Viral Process Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Cytolysis By Host Of Symbiont Cells Bone Morphogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Positive Regulation Of Chondrocyte Proliferation Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Negative Regulation Of Osteoclast Development	Negative Regulation Of Peptidase Activity Defense Response To Bacterium Negative Regulation Of Calcium Ion Import Negative Regulation Of Flagellated Sperm Motility
Pathways		Mtb iron assimilation by chelation Neutrophil degranulation Metal sequestration by antimicrobial proteins Antimicrobial peptides Amyloid fiber formation	Antimicrobial peptides
Drugs		3h-Indole-5,6-Diol Lauric acid Nitrilotriacetic acid alpha-D-Fucopyranose Nimesulide (R)-Atenolol Parecoxib
Diseases
GWAS		AIDS progression ( 21502085) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Early-onset schizophrenia ( 33907183) Inflammatory bowel disease ( 26192919) Macular thickness ( 30535121) Ulcerative colitis ( 26192919)
Interacting Genes		13 interacting genes: ACE2 CALM1 CD14 CEL CP EPPIN ITLN1 LCN1 LRP1 LYZ MUC7 UBC USP7	2 interacting genes: CLU LTF
Entrez ID		4057	57119
HPRD ID		01028	10615
Ensembl ID		ENSG00000012223	ENSG00000101448
Uniprot IDs		B3KSL2 E7ER44 P02788 Q2TUW9 V9HWI4	A0A384NYB9 B2R4Q0 O95925
PDB IDs		1B0L 1BKA 1CB6 1DSN 1EH3 1FCK 1H43 1H44 1H45 1HSE 1L5T 1LCF 1LCT 1LFG 1LFH 1LFI 1LGB 1N76 1SQY 1U62 1VFD 1VFE 1XV4 1XV7 1Z6V 1Z6W 2BJJ 2DP4 2GMC 2GMD 2HD4 2PMS 7JRD 7N88
Enriched GO Terms of Interacting Partners?		Extracellular Region Extracellular Space Endocytic Vesicle Membrane Extracellular Exosome Regulation Of Transport Endocytosis Receptor-mediated Endocytosis Negative Regulation Of Calcium Ion Transport Membrane Raft Opsonin Receptor Activity Oxidoreductase Activity, Acting On Metal Ions, Oxygen As Acceptor Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Brush Border Membrane Import Into Cell Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Other Organism Diterpenoid Metabolic Process Retinoid Metabolic Process Acetylesterase Activity Oxidoreductase Activity, Acting On Metal Ions Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Regulation Of Cardiac Muscle Contraction Phagocytosis Cellular Response To Triacyl Bacterial Lipopeptide Response To External Biotic Stimulus Terpenoid Metabolic Process Ceramide Metabolic Process Ferroxidase Activity Lipoprotein Particle Receptor Binding Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Flagellated Sperm Motility Entry Receptor-mediated Virion Attachment To Host Cell Negative Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction Lipopolysaccharide Receptor Complex Positive Regulation Of Transport Peptidoglycan Immune Receptor Activity Sterol Ester Esterase Activity Isoprenoid Metabolic Process Phospholipid-hydroperoxide Glutathione Peroxidase Activity Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Viral Translation	Regulation Of DNA-binding Transcription Factor Activity Perinuclear Endoplasmic Reticulum Lumen Regulation Of Tumor Necrosis Factor Production Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Neuronal Signal Transduction Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Positive Regulation Of Neurofibrillary Tangle Assembly Humoral Immune Response Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Negative Regulation Of Activation Of Membrane Attack Complex Central Nervous System Myelin Maintenance Immune Complex Clearance Positive Regulation Of Bone Mineralization Involved In Bone Maturation Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Phagocytic Vesicle Lumen Membrane Destabilizing Activity Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Complement-dependent Cytotoxicity Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Negative Regulation Of Osteoclast Development Regulation Of Neurofibrillary Tangle Assembly Protein Import Spherical High-density Lipoprotein Particle Negative Regulation Of Immune System Process Positive Regulation Of Chondrocyte Proliferation Microglial Cell Proliferation Regulation Of Osteoclast Development Positive Regulation Of Immune Response Negative Regulation Of Amyloid Fibril Formation Innate Immune Response Protein Targeting To Vacuole Involved In Autophagy Regulation Of Complement-dependent Cytotoxicity Protein Carrier Chaperone Negative Regulation Of Complement Activation Response To Misfolded Protein Cell Surface Negative Regulation Of ATP-dependent Activity Cytolysis By Host Of Symbiont Cells Negative Regulation Of Membrane Potential Specific Granule Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Antifungal Humoral Response Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Osteoblast Proliferation Myelin Maintenance Apical Dendrite Defense Response To Other Organism
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