LCN2 and LRP2

Number of citations of the paper that reports this interaction (PMID 15670845)
47

Data Source:
HPRD (in vitro)

		LCN2	LRP2
Gene Name		lipocalin 2	low density lipoprotein receptor-related protein 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Extracellular Vesicular Exosome	Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Coated Pit Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Brush Border Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Transporter Activity Iron Ion Binding Small Molecule Binding Protein Homodimerization Activity	Calcium Ion Binding Protein Binding SH3 Domain Binding
	Biological Process	Ion Transport Cellular Iron Ion Homeostasis Response To Virus Response To Herbicide Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Cellular Response To Nutrient Levels Response To Drug Innate Immune Response Transmembrane Transport Protein Homotrimerization Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Retinoid Metabolic Process Protein Glycosylation Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phototransduction, Visible Light Steroid Metabolic Process Cell Proliferation Forebrain Development Vitamin D Metabolic Process Small Molecule Metabolic Process
Pathways		Iron uptake and transport Orphan transporters	Metabolism of lipids and lipoproteins Visual phototransduction Diseases associated with visual transduction Metabolism of steroid hormones and vitamin D Vitamin D (calciferol) metabolism Retinoid metabolism and transport
Drugs		Methyl Nonanoate (Ester) 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Alpha-D-Mannose Carboxymycobactin T Trencam-3,2-Hopo	Urokinase Insulin Regular Insulin, porcine Gentamicin
Diseases
GWAS			Anorexia nervosa ( 21079607) Urate levels ( 20139978)
Protein-Protein Interactions		4 interactors: HGF LRP2 MMP2 MMP9	48 interactors: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RBP1 SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		3934	4036
HPRD ID		02551	02509
Ensembl ID		ENSG00000148346	ENSG00000081479
Uniprot IDs		P80188	P98164 Q7Z5C0 Q7Z5C1
PDB IDs		1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U03 3U0D 4GH7 4IAW 4IAX 4K19	2M0P
Enriched GO Terms of Interacting Partners?		Endodermal Cell Differentiation Endoderm Formation Response To External Stimulus Collagen Catabolic Process Embryo Implantation Collagen Metabolic Process Chemotaxis Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Formation Of Primary Germ Layer Enzyme Linked Receptor Protein Signaling Pathway Organ Development Cell Morphogenesis Gastrulation Locomotion Female Pregnancy Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Receptor Binding Myoblast Proliferation Positive Regulation Of Keratinocyte Migration Ossification Hepatocyte Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component System Development Generation Of Neurons Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Neurogenesis Cellular Response To Hepatocyte Growth Factor Stimulus Intramembranous Ossification Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Positive Regulation Of Myelination Axon Guidance Bone Trabecula Formation Multicellular Organismal Development Cell Development Positive Regulation Of Neuron Projection Regeneration Anatomical Structure Development Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Response To Wounding Regulation Of Catalytic Activity Transport Cell Communication Endocytosis Response To External Stimulus Signaling Receptor Clustering Blood Coagulation Negative Regulation Of Cellular Metabolic Process Hemostasis Vesicle-mediated Transport Cellular Localization Negative Regulation Of Protein Metabolic Process Receptor Localization To Synapse Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Signal Transduction Receptor-mediated Endocytosis Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Signaling Regulation Of Cellular Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Platelet Degranulation Locomotion Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Lipid Metabolic Process Regulation Of Signaling Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Steroid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Secretion By Cell Positive Regulation Of Protein Metabolic Process Protein Localization To Synapse Movement Of Cell Or Subcellular Component Signal Transduction System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Regulation Of Phosphorylation
Tagcloud ?		adipocyte adipocytes adipokine adipose adiposity bdh2 brca butyrate circulating combat conditioned considering constitute dehydrogenase deletion eralpha ferko heightened hydroxy lipocalin media microenvironment migratory pad promotes pure repress responsiveness slc22a17	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Difference) ?		adipocyte adipocytes adipokine adipose adiposity bdh2 brca butyrate circulating combat conditioned considering constitute dehydrogenase deletion eralpha ferko heightened hydroxy lipocalin media microenvironment migratory pad promotes pure repress responsiveness slc22a17	adenosine bioinformatics ciliary consequences damaging dnaaf1 eventual exome exploration harbouring heterozygote hyperprolactinaemia hypopituitarism inexpensive inosine intriguing itp mendelian morbid novo obesity ontology overrepresented teenager trios triphosphate ucp2 variants wes
Tagcloud (Intersection) ?