LCN2 and CTDSP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LCN2	CTDSP2
Description		lipocalin 2	CTD small phosphatase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasmic Vesicle Specific Granule Lumen Cytoplasmic Vesicle Lumen Extracellular Exosome	Nucleus Nucleoplasm
	Molecular Function	Protease Binding Iron Ion Binding Protein Binding Small Molecule Binding Identical Protein Binding Iron Ion Sequestering Activity Enterobactin Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	Immune System Process Monoatomic Ion Transport Iron Ion Transport Apoptotic Process Acute-phase Response Response To Oxidative Stress Short-term Memory Long-term Memory Response To Xenobiotic Stimulus Response To Virus Response To Bacterium Response To Herbicide Response To Toxic Substance Response To Blue Light Response To Fructose Response To Iron(II) Ion Response To Mycotoxin Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Response To Nutrient Levels Cellular Response To Nutrient Levels Response To Lipopolysaccharide Cellular Response To Increased Oxygen Levels Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To X-ray Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Kainic Acid Positive Regulation Of Iron Ion Import Across Plasma Membrane Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Tube Morphogenesis Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Transcription By RNA Polymerase II Protein Dephosphorylation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport	XBP1(S) activates chaperone genes
Drugs		Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
Diseases
GWAS			Height ( 31562340) Hematocrit ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278) Trochanter size ( 31053729)
Interacting Genes		62 interacting genes: ALDH7A1 ALKBH4 ASB10 ASPH BEX2 BMF CAMLG CCNC CDSN CHIC2 CIMIP1 CLMP CTDSP2 EHHADH FAAP20 FAM25A FAM25C FAM25G HDDC2 HGF LAIR2 LNPEP LRP2 LY96 MAGED4B MMP2 MMP9 MSRB3 MYDGF NDUFB2 NEIL2 ODAPH P4HB PDIA4 PELI1 PICK1 PIN1 POLL POU4F2 PRKAA2 PTRH1 RAMP2 SCNM1 SEC61G SGTA SGTB TBC1D21 TRAPPC2L TRH TRIAP1 TRIM32 TSG101 TTC23 TXN2 UBASH3A UBE2F UBE3A UBQLN1 UBQLN2 VEZF1 XRN2 ZBED1	13 interacting genes: AKT1 AR CDCA3 CSF1R EPHA1 EPHA3 INSRR LCN2 N4BP3 POLR2A PTK7 SNAI1 TYRO3
Entrez ID		3934	10106
HPRD ID		02551	12281
Ensembl ID		ENSG00000148346	ENSG00000175215
Uniprot IDs		P80188	O14595
PDB IDs		1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU 6S8V 6SUA 6Z2C 6Z6Z 8UYN 8UZ9	2Q5E
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Cytochrome C From Mitochondria TRC Complex Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Protein-disulfide Reductase Activity Regulation Of ERAD Pathway Protein Targeting To ER Regulation Of Protein Metabolic Process Proteolysis Response To UV Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Response To UV Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Cellular Response To UV-A Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Cellular Response To Light Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Response To UV-A	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Lipid ATP Binding Receptor Complex Transferase Activity Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Cell Migration Cellular Response To Ether Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration Male Sex Determination Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Positive Regulation Of Cell Motility Kinase Binding Positive Regulation Of Locomotion Phosphatidylinositol 3-kinase Binding Cell Motility Regulation Of Protein Localization To Plasma Membrane Protein Autophosphorylation Protein Phosphorylation Response To Ether Negative Regulation Of Toll-like Receptor Signaling Pathway Sex Determination Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Projection Organization Nucleotide Binding Phosphorylation Regulation Of Cellular Component Organization Regulation Of Protein Localization To Cell Periphery Tissue Morphogenesis Cellular Response To Cytokine Stimulus Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Regulation Of Protein Localization To Membrane Positive Regulation Of Morphogenesis Of An Epithelium Regulation Of Toll-like Receptor Signaling Pathway Developmental Process Involved In Reproduction Regulation Of Apoptotic Process Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor
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