LCN2 and MMP2

Number of citations of the paper that reports this interaction (PMID 7683678)
145

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		LCN2	MMP2
Gene Name		lipocalin 2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere
	Molecular Function	Protease Binding Transporter Activity Iron Ion Binding Small Molecule Binding Protein Homodimerization Activity	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Ion Transport Cellular Iron Ion Homeostasis Response To Virus Response To Herbicide Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Cellular Response To Nutrient Levels Response To Drug Innate Immune Response Transmembrane Transport Protein Homotrimerization Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus
Pathways		Iron uptake and transport Orphan transporters	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix
Drugs		Methyl Nonanoate (Ester) 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Alpha-D-Mannose Carboxymycobactin T Trencam-3,2-Hopo	Marimastat Captopril SC-74020
Diseases
GWAS
Protein-Protein Interactions		4 interactors: HGF LRP2 MMP2 MMP9	34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		3934	4313
HPRD ID		02551	00386
Ensembl ID		ENSG00000148346	ENSG00000087245
Uniprot IDs		P80188	P08253
PDB IDs		1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U03 3U0D 4GH7 4IAW 4IAX 4K19	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?		Endodermal Cell Differentiation Endoderm Formation Response To External Stimulus Collagen Catabolic Process Embryo Implantation Collagen Metabolic Process Chemotaxis Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Formation Of Primary Germ Layer Enzyme Linked Receptor Protein Signaling Pathway Organ Development Cell Morphogenesis Gastrulation Locomotion Female Pregnancy Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Receptor Binding Myoblast Proliferation Positive Regulation Of Keratinocyte Migration Ossification Hepatocyte Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component System Development Generation Of Neurons Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Neurogenesis Cellular Response To Hepatocyte Growth Factor Stimulus Intramembranous Ossification Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Positive Regulation Of Myelination Axon Guidance Bone Trabecula Formation Multicellular Organismal Development Cell Development Positive Regulation Of Neuron Projection Regeneration Anatomical Structure Development Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process
Tagcloud ?		adipocyte adipocytes adipokine adipose adiposity bdh2 brca butyrate circulating combat conditioned considering constitute dehydrogenase deletion eralpha ferko heightened hydroxy lipocalin media microenvironment migratory pad promotes pure repress responsiveness slc22a17	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Difference) ?		adipocyte adipocytes adipokine adipose adiposity bdh2 brca butyrate circulating combat conditioned considering constitute dehydrogenase deletion eralpha ferko heightened hydroxy lipocalin media microenvironment migratory pad promotes pure repress responsiveness slc22a17	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Intersection) ?