LCN2 and MMP9

Number of citations of the paper that reports this interaction (PubMedID 23150684)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		LCN2	MMP9
Description		lipocalin 2	matrix metallopeptidase 9
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasmic Vesicle Specific Granule Lumen Cytoplasmic Vesicle Lumen Extracellular Exosome	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protease Binding Iron Ion Binding Protein Binding Small Molecule Binding Identical Protein Binding Iron Ion Sequestering Activity Enterobactin Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Immune System Process Monoatomic Ion Transport Iron Ion Transport Apoptotic Process Acute-phase Response Response To Oxidative Stress Short-term Memory Long-term Memory Response To Xenobiotic Stimulus Response To Virus Response To Bacterium Response To Herbicide Response To Toxic Substance Response To Blue Light Response To Fructose Response To Iron(II) Ion Response To Mycotoxin Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Response To Nutrient Levels Cellular Response To Nutrient Levels Response To Lipopolysaccharide Cellular Response To Increased Oxygen Levels Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To X-ray Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hippocampal Neuron Apoptotic Process Negative Regulation Of Hippocampal Neuron Apoptotic Process Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Kainic Acid Positive Regulation Of Iron Ion Import Across Plasma Membrane Cellular Response To Amyloid-beta Positive Regulation Of Endothelial Tube Morphogenesis Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Reactive Oxygen Species Metabolic Process	Skeletal System Development Positive Regulation Of Protein Phosphorylation Proteolysis Apoptotic Process Embryo Implantation Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Keratinocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To UV-A Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Neuroinflammatory Response Negative Regulation Of Cation Transmembrane Transport Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport	Signaling by SCF-KIT Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling
Drugs		Methyl nonanoate 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo	Glutathione Marimastat Minocycline Captopril Zinc 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid AE-941 PG-530742 Endostatin 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID Oleandrin Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Penile cancer Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS			Abdominal aortic aneurysm ( 27899403) Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 23128233) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mild influenza (H1N1) infection ( 26379185) Systemic sclerosis ( 29293537)
Interacting Genes		62 interacting genes: ALDH7A1 ALKBH4 ASB10 ASPH BEX2 BMF CAMLG CCNC CDSN CHIC2 CIMIP1 CLMP CTDSP2 EHHADH FAAP20 FAM25A FAM25C FAM25G HDDC2 HGF LAIR2 LNPEP LRP2 LY96 MAGED4B MMP2 MMP9 MSRB3 MYDGF NDUFB2 NEIL2 ODAPH P4HB PDIA4 PELI1 PICK1 PIN1 POLL POU4F2 PRKAA2 PTRH1 RAMP2 SCNM1 SEC61G SGTA SGTB TBC1D21 TRAPPC2L TRH TRIAP1 TRIM32 TSG101 TTC23 TXN2 UBASH3A UBE2F UBE3A UBQLN1 UBQLN2 VEZF1 XRN2 ZBED1	32 interacting genes: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFBI THBS1 THBS2 TIMP3
Entrez ID		3934	4318
HPRD ID		02551	00387
Ensembl ID		ENSG00000148346	ENSG00000100985
Uniprot IDs		P80188	P14780
PDB IDs		1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU 6S8V 6SUA 6Z2C 6Z6Z 8UYN 8UZ9	1GKC 1GKD 1ITV 1L6J 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA 4JIJ 4JQG 4WZV 4XCT 5CUH 5I12 5TH6 5TH9 5UE3 5UE4 6ESM 8K5V 8K5W 8K5X 8K5Y
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Cytochrome C From Mitochondria TRC Complex Positive Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Protein-disulfide Reductase Activity Regulation Of ERAD Pathway Protein Targeting To ER Regulation Of Protein Metabolic Process Proteolysis Response To UV Establishment Of Protein Localization To Endoplasmic Reticulum Cellular Response To UV Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Cellular Response To UV-A Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Cellular Response To Light Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Response To UV-A	Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Collagen Type IV Trimer Basement Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Collagen Trimer Endoplasmic Reticulum Lumen Protease Binding Collagen Metabolic Process Angiogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Antimicrobial Humoral Response Collagen Catabolic Process Platelet-derived Growth Factor Binding Cell Surface Receptor Signaling Pathway Endopeptidase Inhibitor Activity CXCR Chemokine Receptor Binding Extracellular Matrix Disassembly Peptidase Inhibitor Activity Metalloendopeptidase Inhibitor Activity Chemokine Activity Response To Amino Acid Regulation Of Anatomical Structure Morphogenesis Collagen Type I Trimer Inflammatory Response Positive Regulation Of Cell Migration Humoral Immune Response Regulation Of Blood Coagulation Positive Regulation Of Cell Motility Regulation Of Hemostasis Heparin Binding Response To Lipid Cellular Response To Growth Factor Stimulus Positive Regulation Of Locomotion Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Lipopolysaccharide Serine-type Endopeptidase Inhibitor Activity Cellular Response To Lipid Cellular Response To Fibroblast Growth Factor Stimulus Defense Response
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