LCN2 and MMP9

Number of citations of the paper that reports this interaction (PMID 1281792)
32

Data Source:
HPRD (in vitro)

		LCN2	MMP9
Gene Name		lipocalin 2	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Transporter Activity Iron Ion Binding Small Molecule Binding Protein Homodimerization Activity	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Collagen Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Ion Transport Cellular Iron Ion Homeostasis Response To Virus Response To Herbicide Positive Regulation Of Gene Expression Siderophore Transport Positive Regulation Of Cell Projection Organization Cellular Response To Nutrient Levels Response To Drug Innate Immune Response Transmembrane Transport Protein Homotrimerization Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Skeletal System Development Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Macrophage Differentiation Collagen Catabolic Process Endodermal Cell Differentiation Positive Regulation Of Apoptotic Process Ephrin Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Keratinocyte Migration Positive Regulation Of Receptor Binding Negative Regulation Of Cation Channel Activity
Pathways		Iron uptake and transport Orphan transporters	Signaling by SCF-KIT EPH-ephrin mediated repulsion of cells Axon guidance Collagen formation Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs		Methyl Nonanoate (Ester) 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Alpha-D-Mannose Carboxymycobactin T Trencam-3,2-Hopo	Marimastat Minocycline Captopril Glucosamine 2-Amino-N,3,3-Trimethylbutanamide 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic Acid 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONE (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDE (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACID
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		4 interactors: HGF LRP2 MMP2 MMP9	32 interactors: AREG BTC CD44 COL1A1 COL1A2 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CXCL1 CXCL5 CXCL6 CXCL8 EPHB2 FN1 HAPLN1 KISS1 LCN2 MMP10 MMP26 MMP7 PLG PRSS2 PZP RECK TFPI TGFB1 THBS1 THBS2 TIMP3
Entrez ID		3934	4318
HPRD ID		02551	00387
Ensembl ID		ENSG00000148346	ENSG00000100985
Uniprot IDs		P80188	P14780
PDB IDs		1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U03 3U0D 4GH7 4IAW 4IAX 4K19	1GKC 1GKD 1ITV 1L6J 1LKG 2OVX 2OVZ 2OW0 2OW1 2OW2 4H1Q 4H2E 4H3X 4H82 4HMA
Enriched GO Terms of Interacting Partners?		Endodermal Cell Differentiation Endoderm Formation Response To External Stimulus Collagen Catabolic Process Embryo Implantation Collagen Metabolic Process Chemotaxis Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Formation Of Primary Germ Layer Enzyme Linked Receptor Protein Signaling Pathway Organ Development Cell Morphogenesis Gastrulation Locomotion Female Pregnancy Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Receptor Binding Myoblast Proliferation Positive Regulation Of Keratinocyte Migration Ossification Hepatocyte Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component System Development Generation Of Neurons Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Neurogenesis Cellular Response To Hepatocyte Growth Factor Stimulus Intramembranous Ossification Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Extracellular Matrix Organization Extracellular Structure Organization Tissue Development Positive Regulation Of Myelination Axon Guidance Bone Trabecula Formation Multicellular Organismal Development Cell Development Positive Regulation Of Neuron Projection Regeneration Anatomical Structure Development Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Blood Vessel Development Vasculature Development Catabolic Process Regulation Of Body Fluid Levels Response To External Stimulus Chemotaxis Cell Migration Positive Regulation Of Chemotaxis Cell Motility Positive Regulation Of Behavior Immune System Process Regulation Of Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Cellular Response To Organic Substance Negative Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Blood Coagulation Negative Regulation Of Peptidase Activity Inflammatory Response Hemostasis Defense Response Cardiovascular System Development Positive Regulation Of Leukocyte Migration Regulation Of Behavior Platelet Activation Response To Organic Substance Positive Regulation Of Cell Migration Response To Cytokine Positive Regulation Of Cell Motility Response To Stress Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Protein Processing Regulation Of Leukocyte Migration Immune Response Leukocyte Migration Regulation Of Endopeptidase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Hydrolase Activity
Tagcloud ?		adipocyte adipocytes adipokine adipose adiposity bdh2 brca butyrate circulating combat conditioned considering constitute dehydrogenase deletion eralpha ferko heightened hydroxy lipocalin media microenvironment migratory pad promotes pure repress responsiveness slc22a17	alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Difference) ?		adipocyte adipocytes adipokine adipose adiposity bdh2 brca butyrate circulating combat conditioned considering constitute dehydrogenase deletion eralpha ferko heightened hydroxy lipocalin media microenvironment migratory pad promotes pure repress responsiveness slc22a17	alkaline alp ccd cleidocranial cocultured ctr ctsk dental dspp dysplasia heterozygous interfered mineralization mineralized mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth
Tagcloud (Intersection) ?