LCAT and A2M

Number of citations of the paper that reports this interaction (PMID 11435418)
7

Data Source:
HPRD (in vitro, in vivo)

		LCAT	A2M
Gene Name		lecithin-cholesterol acyltransferase	alpha-2-macroglobulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Vesicular Exosome	Extracellular Region Cytosol Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Phosphatidylcholine-sterol O-acyltransferase Activity Protein Binding Apolipoprotein A-I Binding	Protease Binding Serine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Cholesterol Esterification Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Small Molecule Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Small GTPase Mediated Signal Transduction Blood Coagulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Lipoprotein metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Lipid digestion, mobilization, and transport	Lipoprotein metabolism Metabolism of lipids and lipoproteins Platelet degranulation Lipid digestion, mobilization, and transport Degradation of the extracellular matrix Formation of Fibrin Clot (Clotting Cascade) Rho GTPase cycle Intrinsic Pathway HDL-mediated lipid transport Response to elevated platelet cytosolic Ca2+ Signaling by Rho GTPases Platelet activation, signaling and aggregation
Drugs			Becaplermin Bacitracin Ocriplasmin
Diseases
GWAS		Coronary heart disease ( 21347282) HDL cholesterol ( 18193043 20864672 19060906 19060910 20686565)
Protein-Protein Interactions		4 interactors: A2M APOA1 APOE EXOSC10	93 interactors: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AFX HMOX2 HSPA5 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK13 KLK2 KLK3 LCAT LEP LONP1 LRP1 LYZ MAST1 MGEA5 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPT8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1L UMPS
Entrez ID		3931	2
HPRD ID		06098	00072
Ensembl ID		ENSG00000213398	ENSG00000175899
Uniprot IDs		P04180	P01023
PDB IDs			1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Esterification High-density Lipoprotein Particle Assembly Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Phospholipid Efflux High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Reverse Cholesterol Transport Plasma Lipoprotein Particle Remodeling Regulation Of Inflammatory Response Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Axon Regeneration Anion Homeostasis Neuron Projection Regeneration Regulation Of Plasma Lipoprotein Particle Levels Positive Regulation Of Lipid Biosynthetic Process Cholesterol Transport Sterol Transport Response To Axon Injury Platelet Degranulation Phototransduction, Visible Light Cholesterol Homeostasis Sterol Homeostasis Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phospholipid Transport Regulation Of Lipid Transport Phototransduction Regulation Of Steroid Metabolic Process Response To Wounding Cellular Localization Negative Regulation Of Inflammatory Response Detection Of Light Stimulus Regulation Of Small GTPase Mediated Signal Transduction Cholesterol Metabolic Process Lipid Homeostasis Lipoprotein Biosynthetic Process Negative Regulation Of Catalytic Activity Isoprenoid Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier	Response To Abiotic Stimulus Response To Stress Regulation Of Cell Activation Response To Stimulus Response To External Stimulus Developmental Process Anatomical Structure Development Regulation Of Immune Response Response To Organic Substance Cellular Response To Stimulus Response To Drug System Development Multicellular Organismal Development Hemostasis Defense Response Regulation Of Cellular Component Organization Regulation Of Body Fluid Levels Regulation Of Immune System Process Blood Coagulation Negative Regulation Of Blood Coagulation Regulation Of Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Organ Development Cellular Response To Organic Substance Negative Regulation Of Wound Healing Regulation Of Protein Metabolic Process Response To Hormone Catabolic Process Negative Regulation Of Platelet Activation Positive Regulation Of Cellular Protein Metabolic Process Platelet Activation Phosphatidylinositol-mediated Signaling Immune Response Regulation Of Phosphorylation Regulation Of Signaling Reproductive Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of DNA Metabolic Process Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Wounding Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Wound Healing
Tagcloud ?		abca1 apoa apoe astrocytes believed catalyzed cerebrospinal cholesteryl clearance cns deficiency discoidal ester esterification facilitating hdl hdls lipidation lipoprotein lipoproteins maturation nascent paralleled particles pathology pronounced ps1 spherical unaffected	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Difference) ?		abca1 apoa apoe astrocytes believed catalyzed cerebrospinal cholesteryl clearance cns deficiency discoidal ester esterification facilitating hdl hdls lipidation lipoprotein lipoproteins maturation nascent paralleled particles pathology pronounced ps1 spherical unaffected	a1at aptt clauss coaliza eclt euglobulin fbg fibrinolysis fibrinolytic foetopathy foetus gdm haemostasis hemocoagulation interleukins kabi les leucocytic macroglobulin microturbidimetry orm orosomucoid prea prealbumin proteinases thrombocytes thrombophilia varicosities wither
Tagcloud (Intersection) ?