LCAT and EXOSC10

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		LCAT	EXOSC10
Description		lecithin-cholesterol acyltransferase	exosome component 10
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Exosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Euchromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Small-subunit Processome Nucleolar Exosome (RNase Complex)
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phosphatidylcholine-sterol O-acyltransferase Activity Phospholipase A2 Activity Sterol Ester Esterase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Apolipoprotein A-I Binding Platelet-activating Factor Acetyltransferase Activity	Nucleotide Binding 3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Single-stranded RNA Binding Nuclease Activity Exonuclease Activity RNA Exonuclease Activity Protein Binding 3'-5' Exonuclease Activity Hydrolase Activity Metal Ion Binding Telomerase RNA Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Aflatoxin Metabolic Process Phosphatidylcholine Metabolic Process Response To Copper Ion Response To Glucocorticoid Regulation Of High-density Lipoprotein Particle Assembly	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair RRNA Processing RNA Processing RNA Catabolic Process DNA Damage Response Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribosomal Small Subunit Biogenesis Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
Pathways		HDL remodeling	Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases		Lecithin:cholesterol acyltransferase deficiency; Norum disease; Fish-eye disease
GWAS		HDL cholesterol ( 19060906 25961943 24507774 24097068 21347282 20864672 20686565 19060910 18193043) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 31217584) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Total cholesterol levels ( 30275531) Total cholesterol levels in HDL ( 29084231)	Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)
Interacting Genes		4 interacting genes: A2M APOA1 APOE EXOSC10	40 interacting genes: ALDH1B1 B9D1 CEBPA CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIC2 SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 USP36 USP7 XRN1 XRN2
Entrez ID		3931	5394
HPRD ID		06098	16180
Ensembl ID		ENSG00000213398	ENSG00000171824
Uniprot IDs		A0A140VK24 P04180	Q01780
PDB IDs		4X96 4XWG 4XX1 5BV7 5TXF 6MVD	2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R 7MQA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipid Efflux Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process High-density Lipoprotein Particle Clearance Lipoprotein Particle Binding Blood Microparticle High-density Lipoprotein Particle Assembly Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Reverse Cholesterol Transport Endocytic Vesicle Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Negative Regulation Of Defense Response Cholesterol Efflux Positive Regulation Of Cholesterol Metabolic Process Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Triglyceride Homeostasis Acylglycerol Homeostasis Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Efflux Signaling Receptor Binding Enzyme Binding Regulation Of Cholesterol Metabolic Process Cellular Response To Amyloid-beta Response To Amyloid-beta Regulation Of Cholesterol Transport Cholesterol Transport Sterol Transport Positive Regulation Of Lipid Transport Phospholipid Transport Amyloid-beta Binding Extracellular Vesicle Regulation Of Rho Protein Signal Transduction Cholesterol Homeostasis	Nuclear MRNA Surveillance MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nuclear Exosome (RNase Complex) RRNA Catabolic Process Exosome (RNase Complex) Nuclear RNA Surveillance RNA Catabolic Process RNA Surveillance Cytoplasmic Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nucleobase-containing Compound Catabolic Process Nucleolar Exosome (RNase Complex) MRNA Metabolic Process RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Exoribonuclease Complex SnRNA 3'-end Processing RNA Metabolic Process RRNA Metabolic Process Nucleobase-containing Compound Metabolic Process 3'-5'-RNA Exonuclease Activity SnRNA Processing Negative Regulation Of Gene Expression RRNA Processing Macromolecule Metabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing RNA 3'-end Processing 5'-3' Exonuclease Activity Macromolecule Catabolic Process RNA Processing DNA Deamination Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Exonuclease Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleolus Sno(s)RNA Metabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing 5'-3' RNA Exonuclease Activity MRNA 3'-UTR AU-rich Region Binding DNA Modification Cysteine-type Deubiquitinase Activity
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