LCAT and EXOSC10

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		LCAT	EXOSC10
Gene Name		lecithin-cholesterol acyltransferase	exosome component 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Vesicular Exosome	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Transcriptionally Active Chromatin
	Molecular Function	Phosphatidylcholine-sterol O-acyltransferase Activity Protein Binding Apolipoprotein A-I Binding	Nucleotide Binding Exoribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Poly(A) RNA Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Cholesterol Esterification Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Small Molecule Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Histone MRNA Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Lipoprotein metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Lipid digestion, mobilization, and transport
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282) HDL cholesterol ( 18193043 20864672 19060906 19060910 20686565)
Protein-Protein Interactions		4 interactors: A2M APOA1 APOE EXOSC10	35 interactors: ALDH1B1 B9D1 CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 MPP6 NOMO1 NOMO2 PTGES2 RPE RUVBL2 SCRIB SKIV2L SSRP1 TARDBP TOX4 UPF2 USP16 USP21 XRN1 XRN2
Entrez ID		3931	5394
HPRD ID		06098	16180
Ensembl ID		ENSG00000213398	ENSG00000171824
Uniprot IDs		P04180	Q01780 Q96G78
PDB IDs			2CPR 3SAF 3SAG 3SAH
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Esterification High-density Lipoprotein Particle Assembly Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Phospholipid Efflux High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Reverse Cholesterol Transport Plasma Lipoprotein Particle Remodeling Regulation Of Inflammatory Response Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Axon Regeneration Anion Homeostasis Neuron Projection Regeneration Regulation Of Plasma Lipoprotein Particle Levels Positive Regulation Of Lipid Biosynthetic Process Cholesterol Transport Sterol Transport Response To Axon Injury Platelet Degranulation Phototransduction, Visible Light Cholesterol Homeostasis Sterol Homeostasis Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phospholipid Transport Regulation Of Lipid Transport Phototransduction Regulation Of Steroid Metabolic Process Response To Wounding Cellular Localization Negative Regulation Of Inflammatory Response Detection Of Light Stimulus Regulation Of Small GTPase Mediated Signal Transduction Cholesterol Metabolic Process Lipid Homeostasis Lipoprotein Biosynthetic Process Negative Regulation Of Catalytic Activity Isoprenoid Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process RRNA Metabolic Process RRNA Processing Aromatic Compound Catabolic Process Cellular Macromolecule Catabolic Process Ribosome Biogenesis Ribonucleoprotein Complex Biogenesis RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process RNA Metabolic Process NcRNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Deamination RNA Surveillance Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis Gene Expression Maturation Of 5.8S RRNA Histone MRNA Catabolic Process RRNA Catabolic Process Cellular Metabolic Process DNA Modification Protein K63-linked Deubiquitination Histone Deubiquitination Histone MRNA Metabolic Process DNA Metabolic Process Chromatin Modification Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Male Germ Cell Proliferation Metabolic Process Chromatin Remodeling MRNA Processing Regulation Of RNA Stability Chromatin Organization Thrombopoietin-mediated Signaling Pathway Posttranscriptional Regulation Of Gene Expression Histone H2A K63-linked Deubiquitination Regulation Of Male Germ Cell Proliferation Endomitotic Cell Cycle
Tagcloud ?		abca1 apoa apoe astrocytes believed catalyzed cerebrospinal cholesteryl clearance cns deficiency discoidal ester esterification facilitating hdl hdls lipidation lipoprotein lipoproteins maturation nascent paralleled particles pathology pronounced ps1 spherical unaffected	18s adopt assumed candidates carry defects exosome extensively functionally fundamental hela homolog its2 itss nucleolar polycistronic posing precede precursors processing recruit ribosomopathies rnas rrna rrnas rrp6 spacers transcribed yeast
Tagcloud (Difference) ?		abca1 apoa apoe astrocytes believed catalyzed cerebrospinal cholesteryl clearance cns deficiency discoidal ester esterification facilitating hdl hdls lipidation lipoprotein lipoproteins maturation nascent paralleled particles pathology pronounced ps1 spherical unaffected	18s adopt assumed candidates carry defects exosome extensively functionally fundamental hela homolog its2 itss nucleolar polycistronic posing precede precursors processing recruit ribosomopathies rnas rrna rrnas rrp6 spacers transcribed yeast
Tagcloud (Intersection) ?