LCAT and APOA1

Number of citations of the paper that reports this interaction (PubMedID 1587806)
0

Data Source:
HPRD (in vivo)

		LCAT	APOA1
Description		lecithin-cholesterol acyltransferase	apolipoprotein A1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Exosome	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Endocytic Vesicle Cytoplasmic Vesicle Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Secretory Granule Lumen Chylomicron Extracellular Exosome Endocytic Vesicle Lumen Blood Microparticle Extracellular Vesicle
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phosphatidylcholine-sterol O-acyltransferase Activity Phospholipase A2 Activity Sterol Ester Esterase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Apolipoprotein A-I Binding Platelet-activating Factor Acetyltransferase Activity	Amyloid-beta Binding Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Apolipoprotein Receptor Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding Protein Homodimerization Activity Chemorepellent Activity Receptor Ligand Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Lipoprotein Particle Binding Cholesterol Transfer Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Aflatoxin Metabolic Process Phosphatidylcholine Metabolic Process Response To Copper Ion Response To Glucocorticoid Regulation Of High-density Lipoprotein Particle Assembly	Endothelial Cell Proliferation Negative Regulation Of Cytokine Production Involved In Immune Response Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Biosynthetic Process Lipid Transport Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Steroid Metabolic Process Cholesterol Metabolic Process Glucocorticoid Metabolic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Lipid Storage Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Adrenal Gland Development Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of Interleukin-1 Beta Production Cholesterol Efflux Phospholipid Efflux Negative Regulation Of Heterotypic Cell-cell Adhesion Amyloid-beta Formation High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Positive Regulation Of Rho Protein Signal Transduction Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Reverse Cholesterol Transport Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Protein Stabilization Negative Chemotaxis Vitamin Transport Positive Regulation Of Stress Fiber Assembly Acylglycerol Homeostasis Phospholipid Homeostasis Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Response To Cytokine Stimulus Triglyceride Homeostasis ERK1 And ERK2 Cascade Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Phospholipid Efflux Cellular Response To Amyloid-beta
Pathways		HDL remodeling	Platelet degranulation ABC transporters in lipid homeostasis PPARA activates gene expression Scavenging of heme from plasma Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective ABCA1 causes TGD Post-translational protein phosphorylation Chylomicron assembly HDL assembly Chylomicron remodeling HDL clearance HDL remodeling Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport Amyloid fiber formation
Drugs			Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Lecithin:cholesterol acyltransferase deficiency; Norum disease; Fish-eye disease	Hypoalphalipoproteinemia Familial amyloidosis
GWAS		HDL cholesterol ( 19060906 25961943 24507774 24097068 21347282 20864672 20686565 19060910 18193043) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 31217584) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Total cholesterol levels ( 30275531) Total cholesterol levels in HDL ( 29084231)	Allergic rhinitis ( 30013184) Apolipoprotein A1 levels ( 32203549) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565 24097068) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Delirium ( 29631748) Diastolic blood pressure ( 27841878) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 19060906 26582766 20686565 24097068 20864672) HDL cholesterol levels ( 28334899) Hearing function ( 25060954) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 27599772 23505323) Infantile hypertrophic pyloric stenosis ( 23989729) LDL cholesterol ( 20864672 24097068 18179892 20686565 19060911) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 24386095) Metabolite levels ( 22916037) Postprandial triglyceride levels ( 32603185) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899 32759990) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 28371326 28548082 26763881 32759990) Triglycerides ( 24097068 26582766 21909109 20864672 20686565 20139978 19074352 19060911 19060906 18193046 18193044 18193043) Very low density lipoprotein cholesterol levels ( 28548082)
Interacting Genes		4 interacting genes: A2M APOA1 APOE EXOSC10	38 interacting genes: ABCA1 ABCA13 AKT2 APOB APOC1 APOF APOL1 APP ATP5F1B BRAP CETP CFHR1 CLEC4G CMTM5 FBLN1 GPLD1 HPR HSP90AA1 JAK3 LBP LCAT MAP7D1 NAXE NDRG1 PCMT1 PDE1A PLTP POLR1H PON1 SCARB1 SPP1 TNFRSF10C TOMM20 TREM2 TRIM15 TTR VKORC1 VWF
Entrez ID		3931	335
HPRD ID		06098	02517
Ensembl ID		ENSG00000213398	ENSG00000118137
Uniprot IDs		A0A140VK24 P04180	A0A024R3E3 P02647
PDB IDs		4X96 4XWG 4XX1 5BV7 5TXF 6MVD	1AV1 1GW3 1GW4 1ODP 1ODQ 1ODR 2MSC 2MSD 2MSE 2N5E 3K2S 3R2P 4V6M 6CC9 6CCH 6CCX 6CLZ 6CM1 6PTS 6PTW 6W4E 6W4F 7KJR 7RSC 7RSE 8EQS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipid Efflux Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process High-density Lipoprotein Particle Clearance Lipoprotein Particle Binding Blood Microparticle High-density Lipoprotein Particle Assembly Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Reverse Cholesterol Transport Endocytic Vesicle Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Negative Regulation Of Defense Response Cholesterol Efflux Positive Regulation Of Cholesterol Metabolic Process Lipoprotein Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Triglyceride Homeostasis Acylglycerol Homeostasis Positive Regulation Of Steroid Metabolic Process Regulation Of Cholesterol Efflux Signaling Receptor Binding Enzyme Binding Regulation Of Cholesterol Metabolic Process Cellular Response To Amyloid-beta Response To Amyloid-beta Regulation Of Cholesterol Transport Cholesterol Transport Sterol Transport Positive Regulation Of Lipid Transport Phospholipid Transport Amyloid-beta Binding Extracellular Vesicle Regulation Of Rho Protein Signal Transduction Cholesterol Homeostasis	High-density Lipoprotein Particle Regulation Of Lipid Transport Regulation Of Cholesterol Transport Lipid Transport Cholesterol Metabolic Process Sterol Metabolic Process Sterol Transport Steroid Metabolic Process Lipoprotein Metabolic Process Apolipoprotein A-I Binding Cholesterol Transport Positive Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Extracellular Space Positive Regulation Of Lipid Transport Regulation Of Cholesterol Efflux High-density Lipoprotein Particle Remodeling Extracellular Region Organic Hydroxy Compound Transport Cholesterol Efflux High-density Lipoprotein Particle Binding Alcohol Metabolic Process Lipid Metabolic Process Apolipoprotein Binding Reverse Cholesterol Transport Lipid Homeostasis Extracellular Exosome Very-low-density Lipoprotein Particle Small Molecule Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Transfer Activity Positive Regulation Of Cholesterol Efflux Phosphatidylcholine Binding Positive Regulation Of Transport Phospholipid Transport Cholesterol Homeostasis Sterol Homeostasis Detection Of Molecule Of Bacterial Origin Regulation Of Lipid Storage Regulation Of Transport Low-density Lipoprotein Particle Glycerolipid Metabolic Process Lipopolysaccharide Transport Low-density Lipoprotein Particle Binding Regulation Of Lipid Catabolic Process Triglyceride Metabolic Process Phosphatidylcholine Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly Organophosphate Ester Transport
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