LCAT

Gene Name		lecithin-cholesterol acyltransferase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space High-density Lipoprotein Particle Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylcholine-sterol O-acyltransferase Activity Protein Binding Apolipoprotein A-I Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylcholine Biosynthetic Process Cholesterol Metabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Cholesterol Esterification Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Small Molecule Metabolic Process Regulation Of High-density Lipoprotein Particle Assembly
Pathways		Lipoprotein metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Lipid digestion, mobilization, and transport
Drugs
Diseases
GWAS		Coronary heart disease ( 21347282) HDL cholesterol ( 18193043 20864672 19060906 19060910 20686565)
Protein-protein Interactions		4 interactors: A2M APOA1 APOE EXOSC10
Entrez ID		3931
HPRD ID		06098
Ensembl ID		ENSG00000213398
Uniprot IDs		P04180
PDB IDs
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Esterification High-density Lipoprotein Particle Assembly Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Phospholipid Efflux High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Reverse Cholesterol Transport Plasma Lipoprotein Particle Remodeling Regulation Of Inflammatory Response Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Regulation Of Cdc42 Protein Signal Transduction Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Axon Regeneration Anion Homeostasis Neuron Projection Regeneration Regulation Of Plasma Lipoprotein Particle Levels Positive Regulation Of Lipid Biosynthetic Process Cholesterol Transport Sterol Transport Response To Axon Injury Platelet Degranulation Phototransduction, Visible Light Cholesterol Homeostasis Sterol Homeostasis Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phospholipid Transport Regulation Of Lipid Transport Phototransduction Regulation Of Steroid Metabolic Process Response To Wounding Cellular Localization Negative Regulation Of Inflammatory Response Detection Of Light Stimulus Regulation Of Small GTPase Mediated Signal Transduction Cholesterol Metabolic Process Lipid Homeostasis Lipoprotein Biosynthetic Process Negative Regulation Of Catalytic Activity Isoprenoid Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier
Tagcloud ?		abca1 apoa apoe astrocytes believed catalyzed cerebrospinal cholesteryl clearance cns deficiency discoidal ester esterification facilitating hdl hdls lipidation lipoprotein lipoproteins maturation nascent paralleled particles pathology pronounced ps1 spherical unaffected