KRT31 and EIF4G1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRT31	EIF4G1
Description		keratin 31	eukaryotic translation initiation factor 4 gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Nucleus Cytoplasm Cytosol Ribosome Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Eukaryotic Initiation Factor 4E Binding Translation Initiation Factor Binding Molecular Adaptor Activity
	Biological Process	Morphogenesis Of An Epithelium Epidermis Development Epithelial Cell Differentiation Intermediate Filament Organization	Behavioral Fear Response Cap-dependent Translational Initiation Translation Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Negative Regulation Of Autophagy Neuron Differentiation Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Response To Stress Energy Homeostasis Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Regulation Of Presynapse Assembly
Pathways		Keratinization Formation of the cornified envelope	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS		Brown vs. black hair color ( 30531825)	Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494)
Interacting Genes		397 interacting genes: A1CF ABI2 ABI3 ABL1 ACTR10 AGR2 AGXT AIMP2 AIRIM AKR7A3 ALDH3B1 ALG13 AMOT AMOTL2 ANKRD36BP1 ANKS1A AQP1 AQP5 ARHGAP35 ARID3A ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 ATXN7L2 AVPI1 B4GALT7 BAD BAG4 BCAS2 BEX1 BEX2 BFSP2 BHLHA9 BRME1 BTC BYSL C19orf73 C1orf216 C3 CA6 CARD9 CATIP CATSPER1 CATSPERT CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC17 CCDC187 CCDC196 CCDC198 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK13 CDK18 CDKN1A CDKN2C CDR2L CEP55 CEP57 CEP57L1 CEP70 CFAP206 CFAP53 CFAP90 CFTR CHCHD2 CHRNG CIMIP4 CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COMT COX5A COX5B CPSF7 CRACR2A CREB5 CRH CTSG CXCL16 CYSRT1 DEF6 DGCR6L DHX37 DHX57 DMRT3 DOCK2 DTNB EIF4E2 EIF4ENIF1 EIF4G1 ENKD1 EPDR1 ESS2 EXOC8 EXOSC5 EXOSC7 FADS2 FAM110A FAM124B FAM50B FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FGF16 FKBP1B FOXB1 FRS3 GAD1 GADD45GIP1 GARIN6 GEM GFAP GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GOLGA6L2 GPS2 GRN GSTP1 HAPLN2 HAUS1 HBA1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB5 HOXC8 HS6ST1 HSD3B7 HSF4 HSPA12B HSPD1 HYAL2 ICAM4 IL16 INPP5D INPP5K INSR ITGB2 ITGB4 ITGB5 JOSD1 KANK2 KCTD9 KDM1A KIAA1217 KIFC3 KLC1 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP4-12 KRTAP5-6 KRTAP9-2 KRTAP9-3 LATS1 LCE1B LCE3C LCE3D LCE3E LCE4A LENG1 LIF LIN37 LINC00526 LMF2 LMNTD2 LMO3 LMO4 LONRF1 LRRC41 MAB21L2 MAP3K7CL MAPKBP1 MARK4 MAZ MID2 MOS MRPL40 MRPL44 MRPS11 MSRB3 MTA1 MXD3 MXI1 MYO15B MYOM1 NAV1 NAXD NEK6 NODAL NPBWR2 NTAQ1 NUDT16L1 NUFIP2 NXF1 OTUB2 OTX1 P2RX7 P3H3 PATL1 PBX3 PDE4DIP PDGFRB PGAP6 PGLS PHC2 PHLDA1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 POLDIP3 POU4F2 POU4F3 PPP1R18 PRF1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRPF6 PRPH PRR19 PRR3 PRR35 PSMA1 PSMB1 PSMC5 PSMG2 PSPC1 PTGER3 PTPMT1 R3HDM2 RAB33A RADIL RAMAC RBFOX2 RBM15 RBM22 RBM7 RCOR3 RHPN1 RIBC1 RPL5 RPS19BP1 RPUSD3 RSPH14 RTP5 SAMD11 SAXO4 SCNM1 SEC14L4 SEMA4C SF1 SFPQ SHC3 SHFL SHISA6 SIRPA SLAIN1 SLC15A3 SLC23A1 SLC25A42 SLC25A6 SLIRP SMARCD1 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SNRPB SNRPC SNW1 SPATA24 SPATA31J1 SPG21 SPON2 SPRING1 SPRY1 SRSF2 SSX2IP STK16 SUV39H1 TACO1 TAPBPL TCEANC TEAD4 TEPSIN TEX28 TFAP2D THAP7 TIAL1 TLE5 TMEM106C TMEM174 TMEM231 TMSB4X TRAF4 TRIML2 TROAP TSEN54 TSG101 TSHZ3 TSNAX TTC23 TTC9C TXLNA TXNL4A TYK2 UACA UBASH3A UNKL USHBP1 USP2 UTP14A UTP23 UXT VASN VPS9D1 WDR25 WFDC6 ZC3H8 ZDHHC1 ZFHX3 ZFYVE21 ZGPAT ZIC1 ZMAT5 ZNF124 ZNF148 ZNF20 ZNF250 ZNF414 ZNF417 ZNF446 ZNF564 ZNF569 ZNF572 ZNF587 ZNF648 ZNF688 ZNF69 ZNF835 ZNRF2P1	42 interacting genes: A1CF ANXA5 ATPAF2 CCDC57 CDKN2D CENPU CIB1 CTBP2 DTX2 EIF1 EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 ENKD1 FXR2 GK HSPB1 HTRA2 HUNK KRT31 KRT34 MKNK1 MKNK2 NCBP1 NCBP2 NTAQ1 PABPC1 PAK2 PDCD4 PEF1 RNF10 SMARCD1 SRPK2 SUMO2 TRAF2 UBE3A UPF2 ZFYVE9
Entrez ID		3881	1981
HPRD ID		03047	06774
Ensembl ID		ENSG00000094796	ENSG00000114867
Uniprot IDs		Q15323	B2RU06 B2RU10 B4DSI9 O95065 Q04637 Q96I65
PDB IDs			1LJ2 1UG3 2W97 4AZA 4F02 5EHC 5EI3 5EIR 5T46 5ZK5 6ZMW 8HUJ 8J7R 8OZ0
Enriched GO Terms of Interacting Partners?		Protein Binding Keratinization Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Epidermis Development Organelle Organization Carbon Dioxide Transport Spliceosomal Complex MRNA Processing Cytoskeleton Nuclear Speck Positive Regulation Of Urine Volume MRNA Metabolic Process Nitric Oxide Transport Nucleus RNA Processing	Translational Initiation Translation Initiation Factor Activity Cytoplasmic Translational Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of Translation RNA Binding Regulation Of Protein Metabolic Process Regulation Of Translational Initiation RNA Cap Binding Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex Cytosol Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Translation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Binding Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RNA 7-methylguanosine Cap Binding Eukaryotic Translation Initiation Factor 3 Complex Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Transport Regulation Of MRNA Metabolic Process RNA Cap Binding Complex Nuclear Cap Binding Complex Multi-eIF Complex MRNA Export From Nucleus Protein Metabolic Process Protein Binding RNA Transport SnRNA Export From Nucleus Regulation Of Primary Metabolic Process RNA Export From Nucleus Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of MRNA 3'-end Processing Viral Translational Termination-reinitiation Regulation Of Gene Expression Calcium-dependent Protein Serine/threonine Kinase Activity Cap-dependent Translational Initiation Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Transport Nucleus Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of MRNA 3'-end Processing
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