KRT31 and KANK2

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		KRT31	KANK2
Description		keratin 31	KN motif and ankyrin repeat domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Cytoplasm Mitochondrion
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Epidermis Development Epithelial Cell Differentiation Intermediate Filament Organization	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Population Proliferation Negative Regulation Of Actin Filament Polymerization Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Vitamin D Receptor Signaling Pathway Kidney Epithelium Development Podocyte Cell Migration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Brown vs. black hair color ( 30531825)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26780889) Coronary artery disease ( 29212778) HDL cholesterol ( 23505323) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 31959993) Low density lipoprotein cholesterol levels ( 32154731 32902719) Mean spheric corpuscular volume ( 32888494) Non-HDL cholesterol levels ( 32902719) Red cell distribution width ( 28957414 32888494 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Triglyceride levels ( 32203549)
Interacting Genes		397 interacting genes: A1CF ABI2 ABI3 ABL1 ACTR10 AGR2 AGXT AIMP2 AIRIM AKR7A3 ALDH3B1 ALG13 AMOT AMOTL2 ANKRD36BP1 ANKS1A AQP1 AQP5 ARHGAP35 ARID3A ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 ATXN7L2 AVPI1 B4GALT7 BAD BAG4 BCAS2 BEX1 BEX2 BFSP2 BHLHA9 BRME1 BTC BYSL C19orf73 C1orf216 C3 CA6 CARD9 CATIP CATSPER1 CATSPERT CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC17 CCDC187 CCDC196 CCDC198 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK13 CDK18 CDKN1A CDKN2C CDR2L CEP55 CEP57 CEP57L1 CEP70 CFAP206 CFAP53 CFAP90 CFTR CHCHD2 CHRNG CIMIP4 CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COMT COX5A COX5B CPSF7 CRACR2A CREB5 CRH CTSG CXCL16 CYSRT1 DEF6 DGCR6L DHX37 DHX57 DMRT3 DOCK2 DTNB EIF4E2 EIF4ENIF1 EIF4G1 ENKD1 EPDR1 ESS2 EXOC8 EXOSC5 EXOSC7 FADS2 FAM110A FAM124B FAM50B FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FGF16 FKBP1B FOXB1 FRS3 GAD1 GADD45GIP1 GARIN6 GEM GFAP GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GOLGA6L2 GPS2 GRN GSTP1 HAPLN2 HAUS1 HBA1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB5 HOXC8 HS6ST1 HSD3B7 HSF4 HSPA12B HSPD1 HYAL2 ICAM4 IL16 INPP5D INPP5K INSR ITGB2 ITGB4 ITGB5 JOSD1 KANK2 KCTD9 KDM1A KIAA1217 KIFC3 KLC1 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP4-12 KRTAP5-6 KRTAP9-2 KRTAP9-3 LATS1 LCE1B LCE3C LCE3D LCE3E LCE4A LENG1 LIF LIN37 LINC00526 LMF2 LMNTD2 LMO3 LMO4 LONRF1 LRRC41 MAB21L2 MAP3K7CL MAPKBP1 MARK4 MAZ MID2 MOS MRPL40 MRPL44 MRPS11 MSRB3 MTA1 MXD3 MXI1 MYO15B MYOM1 NAV1 NAXD NEK6 NODAL NPBWR2 NTAQ1 NUDT16L1 NUFIP2 NXF1 OTUB2 OTX1 P2RX7 P3H3 PATL1 PBX3 PDE4DIP PDGFRB PGAP6 PGLS PHC2 PHLDA1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 POLDIP3 POU4F2 POU4F3 PPP1R18 PRF1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRPF6 PRPH PRR19 PRR3 PRR35 PSMA1 PSMB1 PSMC5 PSMG2 PSPC1 PTGER3 PTPMT1 R3HDM2 RAB33A RADIL RAMAC RBFOX2 RBM15 RBM22 RBM7 RCOR3 RHPN1 RIBC1 RPL5 RPS19BP1 RPUSD3 RSPH14 RTP5 SAMD11 SAXO4 SCNM1 SEC14L4 SEMA4C SF1 SFPQ SHC3 SHFL SHISA6 SIRPA SLAIN1 SLC15A3 SLC23A1 SLC25A42 SLC25A6 SLIRP SMARCD1 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SNRPB SNRPC SNW1 SPATA24 SPATA31J1 SPG21 SPON2 SPRING1 SPRY1 SRSF2 SSX2IP STK16 SUV39H1 TACO1 TAPBPL TCEANC TEAD4 TEPSIN TEX28 TFAP2D THAP7 TIAL1 TLE5 TMEM106C TMEM174 TMEM231 TMSB4X TRAF4 TRIML2 TROAP TSEN54 TSG101 TSHZ3 TSNAX TTC23 TTC9C TXLNA TXNL4A TYK2 UACA UBASH3A UNKL USHBP1 USP2 UTP14A UTP23 UXT VASN VPS9D1 WDR25 WFDC6 ZC3H8 ZDHHC1 ZFHX3 ZFYVE21 ZGPAT ZIC1 ZMAT5 ZNF124 ZNF148 ZNF20 ZNF250 ZNF414 ZNF417 ZNF446 ZNF564 ZNF569 ZNF572 ZNF587 ZNF648 ZNF688 ZNF69 ZNF835 ZNRF2P1	187 interacting genes: ABI3 AEN ANKRD11 AP2B1 ARL14EP ASB15 BEND7 BIRC7 BLZF1 BORCS6 C2orf68 CADPS CAMK2G CAPN3 CARD10 CARD9 CBX8 CCDC33 CCDC57 CCDC88B CDC20B CDC5L CDKL3 CEACAM6 CEP55 CEP63 CEP70 CFAP68 CHCHD3 CHIC2 CINP COG6 CRX CSNK2A1 CUTC CWF19L2 CYTH4 DDIT4L DLGAP3 DPEP2NB DTX2 DYNLL1 EFHC2 EIF4E ELOA EXOSC8 FAM161A FAM90A1 FHL2 FHL3 FKBP6 GADD45GIP1 GATA1 GEMIN4 GKAP1 GMCL1 GMNN GOLGA2 GOLGA6A GOLGA6L9 GPANK1 GPKOW GPSM1 GRB10 HAND2 HOMER3 HSF2BP HSPB2 HSPB2-C11orf52 IHO1 IKZF3 IL16 KIF9 KIFAP3 KIFC3 KRT27 KRT31 KRT34 KRT40 KRT75 KRT86 KRTAP6-3 L3MBTL3 LBX1 LENG1 LHX1 LHX3 LMO1 LMO2 LMO3 LMO4 LZTS1 MAGEB4 MCCD1 MCRS1 MED19 MEOX1 MEOX2 MID2 MITD1 MKRN3 MOB1A MOB3C MORN3 MSS51 MTUS2 MYOZ3 NCOA1 NCOA5 NECAB2 NOS3 NRIP1 NUTM1 OIP5 PAX6 PCBD1 PDE9A PDLIM7 PFDN6 PIBF1 PLAGL2 PLEKHA2 PNKP PPP1CB PRDM14 PRDM6 PRKAR1B PRMT5 PRPF18 PRPF31 PRR5L PSEN1 PSMB4 PSTPIP1 RAB11FIP2 RALBP1 RBCK1 RHOH SCARA5 SCNM1 SERTAD3 SNAPIN SNW1 SORBS3 SRPK2 STAC SYT6 TAX1BP1 TEX11 TFIP11 TGM5 THAP1 THAP6 TIFA TLE5 TOP3B TRAF1 TRAF2 TRAF4 TRIB3 TRIM35 TRIM54 TSGA10 TSGA10IP TSPYL6 TXLNA UBAP2 UBC USHBP1 UTP14C VMAC VPS52 VWC2 WASF3 WASHC1 ZBTB42 ZFP57 ZMAT2 ZMYND12 ZNF212 ZNF414 ZNF512 ZNF648 ZNF774 ZNF784 ZNHIT1 ZRANB1
Entrez ID		3881	25959
HPRD ID		03047	12463
Ensembl ID		ENSG00000094796	ENSG00000197256
Uniprot IDs		Q15323	Q63ZY3
PDB IDs			4HBD 5YBV 6TMD
Enriched GO Terms of Interacting Partners?		Protein Binding Keratinization Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Epidermis Development Organelle Organization Carbon Dioxide Transport Spliceosomal Complex MRNA Processing Cytoskeleton Nuclear Speck Positive Regulation Of Urine Volume MRNA Metabolic Process Nitric Oxide Transport Nucleus RNA Processing	Protein Binding Identical Protein Binding Nucleus Structural Constituent Of Skin Epidermis
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