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KRT31 and CDKN1A
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
KRT31
CDKN1A
Description
keratin 31
cyclin dependent kinase inhibitor 1A
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Cytosol
Cytoskeleton
Intermediate Filament
Keratin Filament
Extracellular Exosome
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Body
Protein-containing Complex
PCNA-p21 Complex
Molecular Function
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Structural Constituent Of Skin Epidermis
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Cyclin Binding
Ubiquitin Protein Ligase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Serine/threonine Kinase Binding
Protein Sequestering Activity
Molecular Function Activator Activity
Molecular Function Inhibitor Activity
Biological Process
Morphogenesis Of An Epithelium
Epidermis Development
Epithelial Cell Differentiation
Intermediate Filament Organization
G1/S Transition Of Mitotic Cell Cycle
In Utero Embryonic Development
Protein Import Into Nucleus
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Ras Protein Signal Transduction
Regulation Of Mitotic Cell Cycle
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Epidermis Development
Response To UV
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Keratinocyte Differentiation
Negative Regulation Of Cell Growth
DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of B Cell Proliferation
Mitotic G1 DNA Damage Checkpoint Signaling
Cellular Response To Amino Acid Starvation
Wound Healing
Tissue Regeneration
Signal Transduction In Response To DNA Damage
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Programmed Cell Death
Keratinocyte Proliferation
Positive Regulation Of DNA Replication
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Growth
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Import Into Nucleus
Regulation Of Cell Cycle
Cellular Response To Cell-matrix Adhesion
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To UV-B
Signal Transduction By P53 Class Mediator
Cellular Senescence
Replicative Senescence
Stress-induced Premature Senescence
Oncogene-induced Cell Senescence
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of DNA Biosynthetic Process
Negative Regulation Of DNA Biosynthetic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Keratinization
Formation of the cornified envelope
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional activation of cell cycle inhibitor p21
The role of GTSE1 in G2/M progression after G2 checkpoint
TFAP2 (AP-2) family regulates transcription of cell cycle factors
Transcriptional regulation by RUNX2
RUNX3 regulates CDKN1A transcription
Neddylation
Transcriptional regulation of granulopoiesis
FOXO-mediated transcription of cell cycle genes
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 fusion proteins
Signaling by ALK fusions and activated point mutants
KEAP1-NFE2L2 pathway
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
Drugs
Valproic acid
Arsenic trioxide
Diseases
Cervical cancer
GWAS
Brown vs. black hair color (
30531825
)
Abdominal aortic aneurysm (
32981348
)
Alanine aminotransferase levels (
34315874
33547301
)
Aspartate aminotransferase levels (
34315874
33547301
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
30529582
31826910
22634755
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
29212778
)
Dilated cardiomyopathy (MTAG) (
33495596
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic conduction measures (
23463857
)
Electrocardiographic traits (
20062063
)
Electrocardiographic traits (multivariate) (
32602732
)
Glaucoma (primary open-angle) (
29891935
)
Heart failure (
31919418
)
Hypertrophic cardiomyopathy (
33495597
33495596
)
Hypertrophic cardiomyopathy (MTAG) (
33495596
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
JT interval (
29874175
)
Left ventricle wall thickness (
33495596
)
Left ventricular fractional shortening (
28394258
)
Left ventricular global circumferential strain (
33495596
)
Left ventricular global radial strain (
33495596
)
Left ventricular mass to end-diastolic volume ratio (
33495596
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
QRS complex (Cornell) (
27659466
)
QRS duration (
31251759
31217584
30679814
27659466
27577874
25035420
21076409
)
Triglyceride levels (
32203549
)
Triglycerides (
27036123
)
Interacting Genes
397 interacting genes:
A1CF
ABI2
ABI3
ABL1
ACTR10
AGR2
AGXT
AIMP2
AIRIM
AKR7A3
ALDH3B1
ALG13
AMOT
AMOTL2
ANKRD36BP1
ANKS1A
AQP1
AQP5
ARHGAP35
ARID3A
ARMC7
ARSJ
ASMTL
ASPSCR1
ATG9A
ATN1
ATXN7L1
ATXN7L2
AVPI1
B4GALT7
BAD
BAG4
BCAS2
BEX1
BEX2
BFSP2
BHLHA9
BRME1
BTC
BYSL
C19orf73
C1orf216
C3
CA6
CARD9
CATIP
CATSPER1
CATSPERT
CBX8
CCDC112
CCDC116
CCDC120
CCDC146
CCDC17
CCDC187
CCDC196
CCDC198
CCDC93
CCER1
CCHCR1
CCNC
CD33
CDC20B
CDK13
CDK18
CDKN1A
CDKN2C
CDR2L
CEP55
CEP57
CEP57L1
CEP70
CFAP206
CFAP53
CFAP90
CFTR
CHCHD2
CHRNG
CIMIP4
CLCNKA
CLDN19
CLDN2
CLEC18A
CNNM3
CNTF
COA5
COMT
COX5A
COX5B
CPSF7
CRACR2A
CREB5
CRH
CTSG
CXCL16
CYSRT1
DEF6
DGCR6L
DHX37
DHX57
DMRT3
DOCK2
DTNB
EIF4E2
EIF4ENIF1
EIF4G1
ENKD1
EPDR1
ESS2
EXOC8
EXOSC5
EXOSC7
FADS2
FAM110A
FAM124B
FAM50B
FAM74A4
FAM90A1
FARS2
FBF1
FBXW5
FGF16
FKBP1B
FOXB1
FRS3
GAD1
GADD45GIP1
GARIN6
GEM
GFAP
GFOD1
GLRX3
GNAI2
GNE
GNG10
GNG5
GOLGA6L2
GPS2
GRN
GSTP1
HAPLN2
HAUS1
HBA1
HBA2
HBZ
HCK
HDAC4
HGS
HNRNPLL
HOXA1
HOXB5
HOXC8
HS6ST1
HSD3B7
HSF4
HSPA12B
HSPD1
HYAL2
ICAM4
IL16
INPP5D
INPP5K
INSR
ITGB2
ITGB4
ITGB5
JOSD1
KANK2
KCTD9
KDM1A
KIAA1217
KIFC3
KLC1
KLC4
KLHL38
KLK8
KRT1
KRT2
KRT20
KRT3
KRT4
KRT5
KRT6A
KRT6B
KRT6C
KRT71
KRT72
KRT73
KRT74
KRT75
KRT76
KRT77
KRT78
KRT79
KRT8
KRT80
KRT81
KRT82
KRT83
KRT85
KRT86
KRTAP4-12
KRTAP5-6
KRTAP9-2
KRTAP9-3
LATS1
LCE1B
LCE3C
LCE3D
LCE3E
LCE4A
LENG1
LIF
LIN37
LINC00526
LMF2
LMNTD2
LMO3
LMO4
LONRF1
LRRC41
MAB21L2
MAP3K7CL
MAPKBP1
MARK4
MAZ
MID2
MOS
MRPL40
MRPL44
MRPS11
MSRB3
MTA1
MXD3
MXI1
MYO15B
MYOM1
NAV1
NAXD
NEK6
NODAL
NPBWR2
NTAQ1
NUDT16L1
NUFIP2
NXF1
OTUB2
OTX1
P2RX7
P3H3
PATL1
PBX3
PDE4DIP
PDGFRB
PGAP6
PGLS
PHC2
PHLDA1
PIN1
PKN1
PKN3
PKP2
PLEKHN1
POLDIP3
POU4F2
POU4F3
PPP1R18
PRF1
PRKAA2
PRKAB2
PRPF18
PRPF31
PRPF6
PRPH
PRR19
PRR3
PRR35
PSMA1
PSMB1
PSMC5
PSMG2
PSPC1
PTGER3
PTPMT1
R3HDM2
RAB33A
RADIL
RAMAC
RBFOX2
RBM15
RBM22
RBM7
RCOR3
RHPN1
RIBC1
RPL5
RPS19BP1
RPUSD3
RSPH14
RTP5
SAMD11
SAXO4
SCNM1
SEC14L4
SEMA4C
SF1
SFPQ
SHC3
SHFL
SHISA6
SIRPA
SLAIN1
SLC15A3
SLC23A1
SLC25A42
SLC25A6
SLIRP
SMARCD1
SMARCE1
SMCP
SMG9
SNAI1
SNRNP25
SNRPB
SNRPC
SNW1
SPATA24
SPATA31J1
SPG21
SPON2
SPRING1
SPRY1
SRSF2
SSX2IP
STK16
SUV39H1
TACO1
TAPBPL
TCEANC
TEAD4
TEPSIN
TEX28
TFAP2D
THAP7
TIAL1
TLE5
TMEM106C
TMEM174
TMEM231
TMSB4X
TRAF4
TRIML2
TROAP
TSEN54
TSG101
TSHZ3
TSNAX
TTC23
TTC9C
TXLNA
TXNL4A
TYK2
UACA
UBASH3A
UNKL
USHBP1
USP2
UTP14A
UTP23
UXT
VASN
VPS9D1
WDR25
WFDC6
ZC3H8
ZDHHC1
ZFHX3
ZFYVE21
ZGPAT
ZIC1
ZMAT5
ZNF124
ZNF148
ZNF20
ZNF250
ZNF414
ZNF417
ZNF446
ZNF564
ZNF569
ZNF572
ZNF587
ZNF648
ZNF688
ZNF69
ZNF835
ZNRF2P1
207 interacting genes:
A1BG
A2M
ABL1
ACTB
ACTL6B
ADAMTS10
AKT1
AKT2
ALAS1
ANGPT2
APLP1
APP
ATP5F1B
ATP6V1A
ATXN3
BAD
BAG6
BCCIP
CASP3
CCDC85B
CCN3
CCNA1
CCNA2
CCNB1
CCNB2
CCND1
CCND2
CCND3
CCNE1
CCNE2
CCT7
CDC45
CDC5L
CDC6
CDC7
CDK1
CDK14
CDK2
CDK3
CDK4
CDK6
CEBPA
CELF3
CENPB
CHEK2
CHGB
CIZ1
CLEC3B
COL4A5
COPS6
CPNE2
CPNE6
CSAD
CSNK2A1
CSNK2B
CTSB
CZIB
DAPK3
DCAF11
DDAH2
DEAF1
DOCK7
DTL
DYNC1I1
EEF1A1
ESR1
EXT2
F13A1
FAF1
FBN3
FGB
FHL3
FLAD1
FNDC11
GADD45A
GADD45B
GADD45G
GAPDH
GCKR
GDF9
GET4
GMNN
GNB2
GNB5
GOLGA2
H1-5
HADHB
HDAC1
HDAC11
HDAC2
HDAC4
HDAC6
HERC5
HMGXB3
HNRNPK
HOOK2
HOXD8
HPD
IKBKG
IKZF3
INCA1
ING5
INPP5K
KIFC3
KLHL23
KMT2B
KRT31
KRTAP3-1
LATS2
LRIF1
LRP2BP
LRR1
LZTS2
MAP3K5
MAPK8
MCM10
MED31
MEOX2
MSH2
MTUS2
NFYA
NGFR
NKD2
NMRK2
NPRL2
NR1H2
NRBP1
NSUN2
OTUB1
PARP1
PCNA
PDE4DIP
PDHB
PIM1
POLD2
PPM1D
PRKACA
PRKAR1B
PRKN
PSMA3
PSMC2
QARS1
RAB1A
RACK1
RAI1
RANBP9
RB1
RBBP4
RBM48
REL
RNF144B
RPL18
RPL35
RPS2
RRM2B
S100A8
SCML2
SDF4
SET
SETDB1
SHISA6
SIPA1
SKP1
SLC25A11
SP110
SPRED1
STAT3
STAT5B
STUB1
SUMO3
TAF5L
TCF4
TEX11
TFIP11
TK1
TLE1
TMSB4X
TNIP1
TNIP2
TNKS
TRAF1
TRIM21
TRIM3
TRIM54
TRIM71
TRMT2A
TSG101
TTLL5
TUBA1A
TUBB2B
TUBB3
TXN
TXNDC11
UBE2D1
UNC119
USHBP1
USP4
VIM
VPS51
WDR73
WIZ
XRCC6
YWHAQ
ZBTB16
ZBTB48
ZNF135
ZNF431
Entrez ID
3881
1026
HPRD ID
03047
00298
Ensembl ID
ENSG00000094796
ENSG00000124762
Uniprot IDs
Q15323
P38936
PDB IDs
1AXC
2ZVV
2ZVW
4RJF
5E0U
6CBI
6CEJ
6CIV
6CIX
6P8H
7KQ0
7KQ1
8GJF
Enriched GO Terms of Interacting Partners
?
Protein Binding
Keratinization
Intermediate Filament Organization
Keratin Filament
Structural Constituent Of Skin Epidermis
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Intermediate Filament
Supramolecular Fiber Organization
Cytoskeleton Organization
Epidermis Development
Organelle Organization
Carbon Dioxide Transport
Spliceosomal Complex
MRNA Processing
Cytoskeleton
Nuclear Speck
Positive Regulation Of Urine Volume
MRNA Metabolic Process
Nitric Oxide Transport
Nucleus
RNA Processing
Nucleus
Nucleoplasm
Regulation Of Primary Metabolic Process
Cytoplasm
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Regulation Of Cell Cycle
Cyclin-dependent Protein Kinase Holoenzyme Complex
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Cyclin Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Cytosol
Regulation Of Programmed Cell Death
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Macromolecule Metabolic Process
Regulation Of Cell Cycle Phase Transition
Cell Division
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Mitotic Cell Cycle
Negative Regulation Of Signal Transduction
Cellular Response To Stress
Negative Regulation Of Intracellular Signal Transduction
Protein Binding
Regulation Of Macromolecule Biosynthetic Process
Protein Kinase Binding
Regulation Of DNA-templated Transcription
Negative Regulation Of Cell Cycle
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
DNA Damage Response
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Cell Cycle
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Fibroblast Proliferation
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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