KRT31 and PRKAA2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRT31	PRKAA2
Description		keratin 31	protein kinase AMP-activated catalytic subunit alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Nucleotide-activated Protein Kinase Complex Ciliary Basal Body Neuronal Cell Body
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis	Nucleotide Binding Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Serine Kinase Activity Histone H2BS36 Kinase Activity
	Biological Process	Morphogenesis Of An Epithelium Epidermis Development Epithelial Cell Differentiation Intermediate Filament Organization	Cytoplasmic Translation Chromatin Organization Chromatin Remodeling Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidylcholine Biosynthetic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Autophagy Signal Transduction Steroid Metabolic Process Cholesterol Metabolic Process Lipid Biosynthetic Process Cellular Response To Starvation Regulation Of Gene Expression Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Response To Muscle Activity Wnt Signaling Pathway Sterol Biosynthetic Process Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress TORC1 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Glycolytic Process Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Rhythmic Process Fatty Acid Homeostasis Protein Localization To Lysosome Regulation Of Stress Granule Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Xenobiotic Stimulus Protein K6-linked Ubiquitination Positive Regulation Of Release Of Cytochrome C From Mitochondria Energy Homeostasis Hepatocyte Apoptotic Process Positive Regulation Of Protein Localization Negative Regulation Of Hepatocyte Apoptotic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly Protein Localization To Lipid Droplet
Pathways		Keratinization Formation of the cornified envelope	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs Nuclear events mediated by NFE2L2 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Brown vs. black hair color ( 30531825)	Lymphocyte count ( 22286170)
Interacting Genes		397 interacting genes: A1CF ABI2 ABI3 ABL1 ACTR10 AGR2 AGXT AIMP2 AIRIM AKR7A3 ALDH3B1 ALG13 AMOT AMOTL2 ANKRD36BP1 ANKS1A AQP1 AQP5 ARHGAP35 ARID3A ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 ATXN7L2 AVPI1 B4GALT7 BAD BAG4 BCAS2 BEX1 BEX2 BFSP2 BHLHA9 BRME1 BTC BYSL C19orf73 C1orf216 C3 CA6 CARD9 CATIP CATSPER1 CATSPERT CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC17 CCDC187 CCDC196 CCDC198 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK13 CDK18 CDKN1A CDKN2C CDR2L CEP55 CEP57 CEP57L1 CEP70 CFAP206 CFAP53 CFAP90 CFTR CHCHD2 CHRNG CIMIP4 CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COMT COX5A COX5B CPSF7 CRACR2A CREB5 CRH CTSG CXCL16 CYSRT1 DEF6 DGCR6L DHX37 DHX57 DMRT3 DOCK2 DTNB EIF4E2 EIF4ENIF1 EIF4G1 ENKD1 EPDR1 ESS2 EXOC8 EXOSC5 EXOSC7 FADS2 FAM110A FAM124B FAM50B FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FGF16 FKBP1B FOXB1 FRS3 GAD1 GADD45GIP1 GARIN6 GEM GFAP GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GOLGA6L2 GPS2 GRN GSTP1 HAPLN2 HAUS1 HBA1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB5 HOXC8 HS6ST1 HSD3B7 HSF4 HSPA12B HSPD1 HYAL2 ICAM4 IL16 INPP5D INPP5K INSR ITGB2 ITGB4 ITGB5 JOSD1 KANK2 KCTD9 KDM1A KIAA1217 KIFC3 KLC1 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP4-12 KRTAP5-6 KRTAP9-2 KRTAP9-3 LATS1 LCE1B LCE3C LCE3D LCE3E LCE4A LENG1 LIF LIN37 LINC00526 LMF2 LMNTD2 LMO3 LMO4 LONRF1 LRRC41 MAB21L2 MAP3K7CL MAPKBP1 MARK4 MAZ MID2 MOS MRPL40 MRPL44 MRPS11 MSRB3 MTA1 MXD3 MXI1 MYO15B MYOM1 NAV1 NAXD NEK6 NODAL NPBWR2 NTAQ1 NUDT16L1 NUFIP2 NXF1 OTUB2 OTX1 P2RX7 P3H3 PATL1 PBX3 PDE4DIP PDGFRB PGAP6 PGLS PHC2 PHLDA1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 POLDIP3 POU4F2 POU4F3 PPP1R18 PRF1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRPF6 PRPH PRR19 PRR3 PRR35 PSMA1 PSMB1 PSMC5 PSMG2 PSPC1 PTGER3 PTPMT1 R3HDM2 RAB33A RADIL RAMAC RBFOX2 RBM15 RBM22 RBM7 RCOR3 RHPN1 RIBC1 RPL5 RPS19BP1 RPUSD3 RSPH14 RTP5 SAMD11 SAXO4 SCNM1 SEC14L4 SEMA4C SF1 SFPQ SHC3 SHFL SHISA6 SIRPA SLAIN1 SLC15A3 SLC23A1 SLC25A42 SLC25A6 SLIRP SMARCD1 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SNRPB SNRPC SNW1 SPATA24 SPATA31J1 SPG21 SPON2 SPRING1 SPRY1 SRSF2 SSX2IP STK16 SUV39H1 TACO1 TAPBPL TCEANC TEAD4 TEPSIN TEX28 TFAP2D THAP7 TIAL1 TLE5 TMEM106C TMEM174 TMEM231 TMSB4X TRAF4 TRIML2 TROAP TSEN54 TSG101 TSHZ3 TSNAX TTC23 TTC9C TXLNA TXNL4A TYK2 UACA UBASH3A UNKL USHBP1 USP2 UTP14A UTP23 UXT VASN VPS9D1 WDR25 WFDC6 ZC3H8 ZDHHC1 ZFHX3 ZFYVE21 ZGPAT ZIC1 ZMAT5 ZNF124 ZNF148 ZNF20 ZNF250 ZNF414 ZNF417 ZNF446 ZNF564 ZNF569 ZNF572 ZNF587 ZNF648 ZNF688 ZNF69 ZNF835 ZNRF2P1	122 interacting genes: ABI1 ABI2 ACACA ACACB AIMP2 AKAP8L AMOT AMOTL2 ANAPC11 APPBP2 ARRDC3 AVPI1 C19orf47 CALCOCO1 CALCOCO2 CCDC172 CCDC33 CCNB1IP1 CDC42EP1 CDR2 CDX4 CPSF7 CTAG2 CYSRT1 DNAAF6 DNM2 DNMT1 DVL3 EEF2K EMILIN1 EPM2A EPN2 FNDC3B FOS GIGYF1 GLI1 GOLGA2 GOLGA6A GRAP2 HAT1 HMBOX1 HNF4A HOMEZ IKZF1 IKZF3 KCTD1 KCTD9 KIAA1328 KIF16B KIF24 KIFC3 KRT16 KRT31 KRTAP1-3 KRTAP10-3 KRTAP10-9 L3MBTL3 LCN2 LEP LZTS2 MKRN3 MORN3 MRFAP1 MTUS2 MYCL MYOZ1 NAB2 NECAB2 NONO NOTCH2NLA NRAP NRBF2 NUTM1 PBXIP1 PFKFB2 PLEKHN1 PRDM6 PRKAB1 PRKAG1 PRKAR1B PRKN PRPH RASAL3 RBBP7 RBPMS REL RFX6 RPTOR SAXO4 SERTAD3 SKIC2 SLA2 SNW1 SOHLH1 SPRY1 STAC2 STK11 TCF4 TFAP2A TIFA TLE5 TMOD1 TRIP13 TRIP6 TSC22D4 UBC UBE2I USH1C USH1G USHBP1 VPS28 VPS37B VPS52 WASHC1 WWP1 WWP2 YPEL3 ZBTB8A ZMYND12 ZNF212 ZNF397 ZSCAN23
Entrez ID		3881	5563
HPRD ID		03047	02735
Ensembl ID		ENSG00000094796	ENSG00000162409
Uniprot IDs		Q15323	P54646
PDB IDs			2H6D 2LTU 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6B2E 6BX6 7MYJ 8BIK
Enriched GO Terms of Interacting Partners?		Protein Binding Keratinization Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Epidermis Development Organelle Organization Carbon Dioxide Transport Spliceosomal Complex MRNA Processing Cytoskeleton Nuclear Speck Positive Regulation Of Urine Volume MRNA Metabolic Process Nitric Oxide Transport Nucleus RNA Processing	Protein Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cytosol Supramolecular Fiber Organization Cytoplasm Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Malonyl-CoA Biosynthetic Process Acetyl-CoA Carboxylase Activity Nucleus Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Prolactin Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Cytoskeleton Cellular Component Assembly Autophagy Regulation Of Growth Transcription Factor Binding Equilibrioception Keratin Filament Microtubule Motor Activity Cullin Family Protein Binding Microtubule
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