KIFC3 and BARD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KIFC3	BARD1
Description		kinesin family member C3	BRCA1 associated RING domain 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Cytoskeleton Kinesin Complex Microtubule Adherens Junction Zonula Adherens Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome Anchoring Junction	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Nuclear Speck BRCA1-BARD1 Complex Cytoplasmic Ribonucleoprotein Granule BRCA1-A Complex BRCA1-B Complex BRCA1-C Complex
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Identical Protein Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Kinase Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Ubiquitin Protein Ligase Activity Ubiquitin-modified Histone Reader Activity Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity
	Biological Process	Microtubule-based Process Microtubule-based Movement Golgi Organization Visual Perception Zonula Adherens Maintenance Epithelial Cell-cell Adhesion	Tissue Homeostasis DNA Repair Regulation Of DNA Repair Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Protein Ubiquitination Negative Regulation Of MRNA 3'-end Processing Homologous Recombination Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Mitotic G2/M Transition Checkpoint Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Protein Export From Nucleus Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Protein K6-linked Ubiquitination DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Damage Checkpoint
Pathways			HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) UCH proteinases Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective DNA double strand break response due to BRCA1 loss of function Defective DNA double strand break response due to BARD1 loss of function Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS			Feeling fed-up ( 29500382) General risk tolerance (MTAG) ( 30643258) Neuroblastoma ( 21124317 22941191) Neuroblastoma (high-risk) ( 19412175) Neuroblastoma (MYCN amplification) ( 28924153) Neurociticism ( 29500382) Sporadic neuroblastoma ( 28545128)
Interacting Genes		213 interacting genes: ABI2 ABI3 AIRIM ANKRD23 ANXA13 APP APPL2 ARNT2 ATF2 AXIN2 BARD1 BCL6 BEGAIN BFSP1 BYSL CARD9 CATSPERT CBFA2T2 CBX8 CBY2 CCDC102B CCDC136 CCDC146 CCDC187 CCDC198 CCDC28A CCDC33 CCHCR1 CCND3 CDC37 CDK18 CDKN1A CDR2 CEP55 CEP57L1 CLIP4 COG3 COG7 CREB5 CWF19L2 CYTH4 DCTN2 DCX DEUP1 DISC1 DSCAM DTNBP1 EIF3D ENKD1 ESRRG EXOC5 EXOC7 EXOC8 FAM124A FAM161A FAM90A1 FANCL FBXO7 FCHSD2 FEM1A FLYWCH1 FOSL1 GADD45GIP1 GEM GIGYF1 GMCL1 GOLGA1 GOLGA2 GORASP2 HAUS1 HMG20A HOMEZ HSBP1 HSF2BP ICA1L IGFN1 IHO1 IKZF3 IL16 IQUB ITGB3BP KANK2 KANSL1 KDM1A KIAA0753 KRT14 KRT15 KRT16 KRT18 KRT19 KRT26 KRT3 KRT31 KRT32 KRT35 KRT38 KRT4 KRT40 KRT5 KRT6A KRT6B KRT6C KRT75 KRT76 KRT8 KRTAP19-5 KRTAP19-6 LBX1 LENG1 LIN37 LNX1 LZTS1 LZTS2 MBD3L1 MCC MCM7 MED4 MFAP1 MID2 MKRN3 MOS MRFAP1 MTUS2 MYO15B NAB2 NDC80 NDEL1 NEBL NECAB2 NEDD4 NEDD4L NEFL NSMF NUP62 PFDN6 PHC2 PIAS2 PIBF1 PIN1 PNMA5 PPP1R13B PRDM6 PRKAA2 PRPF18 PRPF31 PRPH PSMB1 RABIF RAD51D RAD54L2 RBM41 RSPH14 RUNX1T1 SCEL SCNM1 SCOC SHISA6 SIAH1 SMARCE1 SNAP29 SORBS3 SOX30 SOX5 SPATA2 SPATC1L SSX2IP STMN3 STX11 STX1A SVIL SYCE1 SYCE2 SYT6 SYTL4 TASOR2 TBC1D22B TCEANC TFIP11 TLE5 TNIP1 TNNI1 TPM3 TRAF2 TRIM14 TRIM23 TRIM27 TRIM41 TRIM54 TSG101 TSGA10IP TSR2 UBC USH1G USP2 VIM VPS52 WASF3 ZBED1 ZBTB16 ZBTB8A ZGPAT ZNF180 ZNF20 ZNF250 ZNF417 ZNF446 ZNF572 ZNF655 ZNF688 ZNF774 ZNF785 ZNF835 ZRANB1	131 interacting genes: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 AXIN2 BCCIP BCL3 BGLT3 BRCA1 BRD7 CAP1 CBX1 CBX3 CBX5 CCDC136 CDK1 CDK2 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CSTF1 DCAF8L2 DCC DDX39B DNAI7 ELP1 ESR1 EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AC20 H2AC4 H2BC3 H3C1 HAP1 HNRNPC HNRNPLL HSF2BP HSPA14 IDI1 IKZF1 ING5 KAT5 KAT7 KBTBD7 KIFC3 KRT40 LARP7 LDOC1 LGALS8 LRIF1 MACROH2A1 MAGED1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT-ND1 MT2A MTUS2 NFKB1 NFKBIA NPC2 PCBP2 PDXK PDZD8 PIAS1 PIAS4 PIN1 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RABEP1 RAD51 RBBP8 RBMY2BP RNF10 RPS20 SELENBP1 SETDB1 SKIC8 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TERF2 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WRN XRCC6 ZFP64 ZHX1 ZNF121 ZNF655
Entrez ID		3801	580
HPRD ID		05171	03354
Ensembl ID		ENSG00000140859	ENSG00000138376
Uniprot IDs		B7Z5U4 B7Z808 B7Z896 F5H3M2 H3BMZ5 Q9BVG8	A0A087WZ19 A0AVN2 C9IYG1 F6MDI0 F6MDI1 F6MDI2 Q99728
PDB IDs		5WDE	1JM7 2NTE 2R1Z 3C5R 3FA2 6M14 7E8I 7JZV 7LYB 7LYC 8GRQ
Enriched GO Terms of Interacting Partners?		Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament Protein Binding Cytoskeleton Organization Supramolecular Fiber Organization Organelle Organization Cytoskeleton Structural Constituent Of Cytoskeleton Identical Protein Binding Structural Molecule Activity Nucleus Keratinization Centrosome Organelle Localization Microtubule-based Process Microtubule Organizing Center Epithelial Cell Differentiation Positive Regulation Of Actin Nucleation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Differentiation Hepatocyte Apoptotic Process Microtubule Cytoskeleton Organization Flemming Body Cytosol Regulation Of Transcription By RNA Polymerase II Chromosome Localization Epidermis Development Metaphase Chromosome Alignment Cellular Developmental Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Zinc Ion Binding Regulation Of Neuron Projection Development Post-translational Protein Modification Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Activity Intermediate Filament Polymerization Or Depolymerization Vesicle Tethering Involved In Exocytosis Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Neurofilament Cytoskeleton Organization Scaffold Protein Binding Negative Regulation Of DNA-templated Transcription Developmental Process Epithelial Cell Apoptotic Process	DNA Damage Response Nucleoplasm DNA Repair Ubiquitin Conjugating Enzyme Activity DNA Metabolic Process Chromosome Nucleus Chromatin Organization Nucleic Acid Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Protein K48-linked Ubiquitination Double-strand Break Repair Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome Organization Enzyme Binding Modification-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA Metabolic Process Ubiquitin Protein Ligase Binding Post-translational Protein Modification Maintenance Of DNA Repeat Elements Heterochromatin Formation Negative Regulation Of DNA Recombination Chromatin Binding Protein Monoubiquitination Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Positive Regulation Of DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Single Guanine Insertion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression, Epigenetic
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