KIFC3 and BCL6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KIFC3	BCL6
Description		kinesin family member C3	BCL6 transcription repressor
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Cytoskeleton Kinesin Complex Microtubule Adherens Junction Zonula Adherens Microtubule Cytoskeleton Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome Anchoring Junction	Nucleus Nucleoplasm Replication Fork Nucleolus Golgi Apparatus Paraspeckles
	Molecular Function	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding Identical Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Microtubule-based Process Microtubule-based Movement Golgi Organization Visual Perception Zonula Adherens Maintenance Epithelial Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Cytokine Production Negative Regulation Of Cell-matrix Adhesion Plasma Cell Differentiation Immune System Process Germinal Center Formation Regulation Of Germinal Center Formation Regulation Of Immune System Process Negative Regulation Of Type 2 Immune Response Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response DNA Damage Response Cell-matrix Adhesion Rho Protein Signal Transduction Spermatogenesis Intracellular Protein Localization Cell Population Proliferation Pyramidal Neuron Differentiation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Heterochromatin Formation Negative Regulation Of Mast Cell Cytokine Production Mononuclear Cell Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response B Cell Proliferation Regulation Of Cell Population Proliferation Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Memory T Cell Differentiation T-helper 2 Cell Differentiation Regulation Of T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Isotype Switching To IgE Isotypes Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Cell Motility Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation Negative Regulation Of Plasma Cell Differentiation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Cell Motility Negative Regulation Of Cellular Senescence
Pathways			Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes
Drugs
Diseases			Hairy-cell leukemia
GWAS			Adverse response to drug ( 30420678) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Appendicular lean mass ( 33097823) Asthma ( 31959851) B cell non-Hodgkin lymphoma ( 23749188) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood urea nitrogen levels ( 29403010) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) PR interval ( 23534349) Pulmonary function (smoking interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Triglyceride levels ( 32203549) Type 2 diabetes ( 25760438)
Interacting Genes		213 interacting genes: ABI2 ABI3 AIRIM ANKRD23 ANXA13 APP APPL2 ARNT2 ATF2 AXIN2 BARD1 BCL6 BEGAIN BFSP1 BYSL CARD9 CATSPERT CBFA2T2 CBX8 CBY2 CCDC102B CCDC136 CCDC146 CCDC187 CCDC198 CCDC28A CCDC33 CCHCR1 CCND3 CDC37 CDK18 CDKN1A CDR2 CEP55 CEP57L1 CLIP4 COG3 COG7 CREB5 CWF19L2 CYTH4 DCTN2 DCX DEUP1 DISC1 DSCAM DTNBP1 EIF3D ENKD1 ESRRG EXOC5 EXOC7 EXOC8 FAM124A FAM161A FAM90A1 FANCL FBXO7 FCHSD2 FEM1A FLYWCH1 FOSL1 GADD45GIP1 GEM GIGYF1 GMCL1 GOLGA1 GOLGA2 GORASP2 HAUS1 HMG20A HOMEZ HSBP1 HSF2BP ICA1L IGFN1 IHO1 IKZF3 IL16 IQUB ITGB3BP KANK2 KANSL1 KDM1A KIAA0753 KRT14 KRT15 KRT16 KRT18 KRT19 KRT26 KRT3 KRT31 KRT32 KRT35 KRT38 KRT4 KRT40 KRT5 KRT6A KRT6B KRT6C KRT75 KRT76 KRT8 KRTAP19-5 KRTAP19-6 LBX1 LENG1 LIN37 LNX1 LZTS1 LZTS2 MBD3L1 MCC MCM7 MED4 MFAP1 MID2 MKRN3 MOS MRFAP1 MTUS2 MYO15B NAB2 NDC80 NDEL1 NEBL NECAB2 NEDD4 NEDD4L NEFL NSMF NUP62 PFDN6 PHC2 PIAS2 PIBF1 PIN1 PNMA5 PPP1R13B PRDM6 PRKAA2 PRPF18 PRPF31 PRPH PSMB1 RABIF RAD51D RAD54L2 RBM41 RSPH14 RUNX1T1 SCEL SCNM1 SCOC SHISA6 SIAH1 SMARCE1 SNAP29 SORBS3 SOX30 SOX5 SPATA2 SPATC1L SSX2IP STMN3 STX11 STX1A SVIL SYCE1 SYCE2 SYT6 SYTL4 TASOR2 TBC1D22B TCEANC TFIP11 TLE5 TNIP1 TNNI1 TPM3 TRAF2 TRIM14 TRIM23 TRIM27 TRIM41 TRIM54 TSG101 TSGA10IP TSR2 UBC USH1G USP2 VIM VPS52 WASF3 ZBED1 ZBTB16 ZBTB8A ZGPAT ZNF180 ZNF20 ZNF250 ZNF417 ZNF446 ZNF572 ZNF655 ZNF688 ZNF774 ZNF785 ZNF835 ZRANB1	91 interacting genes: ANKRD53 ARHGEF9 ARRDC3 ATP23 BCL11A BCL6B BCOR BLZF1 CABP4 CDK19 CDK8 CFAP161 CFAP97D1 CHD3 CNOT2 CRBN CREBBP CTNNB1 CUTC DVL2 ENO1 EP300 FBXO11 GATA1 GLRX3 GOLGA2 HDAC1 HDAC4 HDAC5 HDAC7 HDAC9 IHO1 IRF4 JUN JUNB JUND KIFC3 KLHL12 KLHL20 KRTAP13-1 KRTAP13-2 KRTAP19-1 LIMS3 LIMS4 MAPK1 MDFI MED17 MED6 MTA3 MTUS2 NCOR1 NCOR2 PAK1 PBX4 PELI1 PFDN5 PIN1 PML POF1B PPARD PPTC7 PRKD3 PSMB4 RAF1 REL RUNX1T1 SIAH1 SIN3A SNCA SP1 SPI1 SPMIP2 SPMIP4 SPMIP6 SSX2IP TEKT4 TFIP11 TLE5 TP53 TP53BP1 TRAF1 TRAF2 TRIB3 TWIST1 WDR83 WNK4 ZBTB16 ZBTB17 ZBTB7A ZBTB7B ZNHIT1
Entrez ID		3801	604
HPRD ID		05171	00180
Ensembl ID		ENSG00000140859	ENSG00000113916
Uniprot IDs		B7Z5U4 B7Z808 B7Z896 F5H3M2 H3BMZ5 Q9BVG8	B5B0A5 P41182
PDB IDs		5WDE	1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 4U2M 5H7G 5H7H 5MW2 5MW6 5MWD 5N1X 5N1Z 5N20 5N21 5X4M 5X4N 5X4O 5X4P 5X4Q 5X9O 5X9P 6C3L 6C3N 6CQ1 6EW6 6EW7 6EW8 6TBT 6TCJ 6TOF 6TOG 6TOH 6TOI 6TOJ 6TOK 6TOL 6TOM 6TON 6TOO 6XMX 6XWF 6XXS 6XYX 6XZZ 6Y17 6ZBU 7BDE 7GUD 7GUE 7GUF 7GUG 7GUH 7GUI 7GUJ 7GUK 7GUL 7GUM 7GUN 7GUO 7GUP 7GUQ 7GUR 7GUS 7GUT 7GUU 7GUV 7GUW 7GUX 7GUY 7GUZ 7GV0 7GV1 7GV2 7GV3 7GV4 7GV5 7GV6 7GV7 7GV8 7GV9 7GVA 7GVB 7GVC 7GVD 7GVE 7GVF 7GVG 7GVH 7GVI 7GVJ 7GVK 7GVL 7GVM 7GVN 7GVO 7GVP 7GVQ 7GVR 7GVS 7GVT 7GVU 7GVV 7GVW 7GVX 7GVY 7GVZ 7GW0 7GW1 7GW2 7GW3 7GW4 7GW5 7GW6 7GW7 7GW8 7GW9 7GWA 7GWB 7GWC 7GWD 7GWE 7GWF 7GWG 7GWH 7GWI 7GWJ 7GWK 7GWL 7GWM 7GWN 7GWO 7GWP 7GWQ 7GWR 7GWS 7GWT 7GWU 7GWV 7GWW 7GWX 7GWY 7GWZ 7GX0 7GX1 7GX2 7GX3 7GX4 7GX5 7GX6 7GX7 7GX8 7GX9 7GXA 7GXB 7GXC 7GXD 7GXE 7GXF 7GXG 7GXH 7GXI 7GXJ 7GXK 7GXL 7GXM 7GXN 7GXO 7GXP 7GXQ 7GXR 7GXS 7GXT 7GXU 7GXV 7GXW 7GXX 7GXY 7GXZ 7GY0 7GY1 7GY2 7GY3 7LWE 7LWF 7LWG 7LZQ 7LZR 7LZS 7OKD 7OKE 7OKF 7OKG 7OKH 7OKI 7OKJ 7OKK 7OKL 7OKM 7Q7R 7Q7S 7Q7T 7Q7U 7Q7V 7QK0 7RUW 7RUX 7RUY 7RUZ 7RV0 7RV1 7RV2 7RV3 7RV4 7RV5 7RV6 7RV7 7RV8 7RV9 7T0S 7T0T 7T0U 7ZWN 7ZWO 7ZWP 7ZWQ 7ZWR 7ZWS 7ZWT 7ZWU 7ZWV 7ZWW 7ZWX 7ZWY 7ZWZ 8AS9 8C78
Enriched GO Terms of Interacting Partners?		Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Structural Constituent Of Skin Epidermis Keratin Filament Protein Binding Cytoskeleton Organization Supramolecular Fiber Organization Organelle Organization Cytoskeleton Structural Constituent Of Cytoskeleton Identical Protein Binding Structural Molecule Activity Nucleus Keratinization Centrosome Organelle Localization Microtubule-based Process Microtubule Organizing Center Epithelial Cell Differentiation Positive Regulation Of Actin Nucleation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Differentiation Hepatocyte Apoptotic Process Microtubule Cytoskeleton Organization Flemming Body Cytosol Regulation Of Transcription By RNA Polymerase II Chromosome Localization Epidermis Development Metaphase Chromosome Alignment Cellular Developmental Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Zinc Ion Binding Regulation Of Neuron Projection Development Post-translational Protein Modification Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Activity Intermediate Filament Polymerization Or Depolymerization Vesicle Tethering Involved In Exocytosis Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Neurofilament Cytoskeleton Organization Scaffold Protein Binding Negative Regulation Of DNA-templated Transcription Developmental Process Epithelial Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Transcription Repressor Complex DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Transcription Corepressor Activity Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Nucleoplasm Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Histone Deacetylase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Protein Lysine Deacetylase Activity Transcription Corepressor Binding Positive Regulation Of Metabolic Process Transcription Coactivator Binding Chromatin Organization Negative Regulation Of Developmental Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?