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KIFC3 and PHC2
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
KIFC3
PHC2
Description
kinesin family member C3
polyhomeotic homolog 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Golgi Apparatus
Centrosome
Cytoskeleton
Kinesin Complex
Microtubule
Adherens Junction
Zonula Adherens
Microtubule Cytoskeleton
Membrane
Cytoplasmic Vesicle Membrane
Cytoplasmic Vesicle
Extracellular Exosome
Anchoring Junction
Heterochromatin
Nucleus
Nucleoplasm
PcG Protein Complex
PRC1 Complex
Molecular Function
Nucleotide Binding
Microtubule Motor Activity
Protein Binding
ATP Binding
Microtubule Binding
Identical Protein Binding
DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
Histone Binding
Identical Protein Binding
Metal Ion Binding
Biological Process
Microtubule-based Process
Microtubule-based Movement
Golgi Organization
Visual Perception
Zonula Adherens Maintenance
Epithelial Cell-cell Adhesion
Spermatogenesis
Negative Regulation Of DNA-templated Transcription
Pathways
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Drugs
Diseases
GWAS
Adventurousness (
30643258
)
Appendicular lean mass (
33097823
)
Blood urea nitrogen levels (
29403010
31152163
)
General risk tolerance (MTAG) (
30643258
)
Pancreas volume (
34128465
)
Pulse pressure (
30224653
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Smoking status (ever vs never smokers) (
30643258
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31630189
)
Interacting Genes
213 interacting genes:
ABI2
ABI3
AIRIM
ANKRD23
ANXA13
APP
APPL2
ARNT2
ATF2
AXIN2
BARD1
BCL6
BEGAIN
BFSP1
BYSL
CARD9
CATSPERT
CBFA2T2
CBX8
CBY2
CCDC102B
CCDC136
CCDC146
CCDC187
CCDC198
CCDC28A
CCDC33
CCHCR1
CCND3
CDC37
CDK18
CDKN1A
CDR2
CEP55
CEP57L1
CLIP4
COG3
COG7
CREB5
CWF19L2
CYTH4
DCTN2
DCX
DEUP1
DISC1
DSCAM
DTNBP1
EIF3D
ENKD1
ESRRG
EXOC5
EXOC7
EXOC8
FAM124A
FAM161A
FAM90A1
FANCL
FBXO7
FCHSD2
FEM1A
FLYWCH1
FOSL1
GADD45GIP1
GEM
GIGYF1
GMCL1
GOLGA1
GOLGA2
GORASP2
HAUS1
HMG20A
HOMEZ
HSBP1
HSF2BP
ICA1L
IGFN1
IHO1
IKZF3
IL16
IQUB
ITGB3BP
KANK2
KANSL1
KDM1A
KIAA0753
KRT14
KRT15
KRT16
KRT18
KRT19
KRT26
KRT3
KRT31
KRT32
KRT35
KRT38
KRT4
KRT40
KRT5
KRT6A
KRT6B
KRT6C
KRT75
KRT76
KRT8
KRTAP19-5
KRTAP19-6
LBX1
LENG1
LIN37
LNX1
LZTS1
LZTS2
MBD3L1
MCC
MCM7
MED4
MFAP1
MID2
MKRN3
MOS
MRFAP1
MTUS2
MYO15B
NAB2
NDC80
NDEL1
NEBL
NECAB2
NEDD4
NEDD4L
NEFL
NSMF
NUP62
PFDN6
PHC2
PIAS2
PIBF1
PIN1
PNMA5
PPP1R13B
PRDM6
PRKAA2
PRPF18
PRPF31
PRPH
PSMB1
RABIF
RAD51D
RAD54L2
RBM41
RSPH14
RUNX1T1
SCEL
SCNM1
SCOC
SHISA6
SIAH1
SMARCE1
SNAP29
SORBS3
SOX30
SOX5
SPATA2
SPATC1L
SSX2IP
STMN3
STX11
STX1A
SVIL
SYCE1
SYCE2
SYT6
SYTL4
TASOR2
TBC1D22B
TCEANC
TFIP11
TLE5
TNIP1
TNNI1
TPM3
TRAF2
TRIM14
TRIM23
TRIM27
TRIM41
TRIM54
TSG101
TSGA10IP
TSR2
UBC
USH1G
USP2
VIM
VPS52
WASF3
ZBED1
ZBTB16
ZBTB8A
ZGPAT
ZNF180
ZNF20
ZNF250
ZNF417
ZNF446
ZNF572
ZNF655
ZNF688
ZNF774
ZNF785
ZNF835
ZRANB1
78 interacting genes:
AEN
AFG3L2
AIRIM
AP1M1
BMI1
BSDC1
BYSL
CARD9
CRK
CRKL
DNMT1
DRG1
ENKD1
FAM124A
FAM13C
FAM161A
FAM74A1
FAM74A4
FHL3
FOSB
FXR1
FXR2
GFI1B
GRB2
H3-4
HDAC7
KAT5
KBTBD7
KDM1A
KIFC3
KLHDC7B
KRT31
L3MBTL3
LMO1
LMO2
LMO3
MAB21L3
MAGEB6
MAPK14
MAPK6
MAPKAPK2
MCM2
MCRS1
MFAP1
MLLT6
MORF4L2
NCK1
PCGF3
PHC1
PLAGL2
PLK1
POLR2L
PPP1R16B
PRKAA1
PRPF3
PRPF31
RBM39
RNF2
RPL7
RWDD2B
SCMH1
SDCBP
SFMBT1
SIAH1
SMAD3
SPATC1L
SSX2IP
SYT16
TAB1
THAP7
TMEM70
TRIM41
TRIM55
TRIM63
ZBTB24
ZGPAT
ZMAT2
ZNF417
Entrez ID
3801
1912
HPRD ID
05171
10340
Ensembl ID
ENSG00000140859
ENSG00000134686
Uniprot IDs
B7Z5U4
B7Z808
B7Z896
F5H3M2
H3BMZ5
Q9BVG8
A0A0A0MSI2
A0A994J5J9
Q8IXK0
PDB IDs
5WDE
Enriched GO Terms of Interacting Partners
?
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Intermediate Filament Organization
Intermediate Filament
Structural Constituent Of Skin Epidermis
Keratin Filament
Protein Binding
Cytoskeleton Organization
Supramolecular Fiber Organization
Organelle Organization
Cytoskeleton
Structural Constituent Of Cytoskeleton
Identical Protein Binding
Structural Molecule Activity
Nucleus
Keratinization
Centrosome
Organelle Localization
Microtubule-based Process
Microtubule Organizing Center
Epithelial Cell Differentiation
Positive Regulation Of Actin Nucleation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Cell Differentiation
Hepatocyte Apoptotic Process
Microtubule Cytoskeleton Organization
Flemming Body
Cytosol
Regulation Of Transcription By RNA Polymerase II
Chromosome Localization
Epidermis Development
Metaphase Chromosome Alignment
Cellular Developmental Process
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Zinc Ion Binding
Regulation Of Neuron Projection Development
Post-translational Protein Modification
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Ubiquitin Protein Ligase Activity
Intermediate Filament Polymerization Or Depolymerization
Vesicle Tethering Involved In Exocytosis
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Neurofilament Cytoskeleton Organization
Scaffold Protein Binding
Negative Regulation Of DNA-templated Transcription
Developmental Process
Epithelial Cell Apoptotic Process
Nucleus
Nucleoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Negative Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
PRC1 Complex
Negative Regulation Of Macromolecule Metabolic Process
Chromatin Binding
Negative Regulation Of Metabolic Process
Protein Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Zinc Ion Binding
Diapedesis
Negative Regulation Of Biosynthetic Process
PcG Protein Complex
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Chromatin Remodeling
Identical Protein Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Rac Protein Signal Transduction
Regulation Of Primary Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Helper T Cell Diapedesis
DNA-binding Transcription Factor Binding
Response To Ionizing Radiation
RING-like Zinc Finger Domain Binding
Cerebellar Neuron Development
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
Regulation Of Protein Localization To Nucleus
U2-type Precatalytic Spliceosome
Heterochromatin
Response To Muramyl Dipeptide
Regulation Of Macromolecule Metabolic Process
Histone H2AK119 Ubiquitin Ligase Activity
Histone Binding
Metal Ion Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Metabolic Process
Epigenetic Regulation Of Gene Expression
Ephrin Receptor Binding
Promoter-specific Chromatin Binding
MLL1 Complex
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