KIFC3 and PRKAA2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KIFC3	PRKAA2
Gene Name		kinesin family member C3	protein kinase, AMP-activated, alpha 2 catalytic subunit
Image
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Centrosome Kinesin Complex Microtubule Zonula Adherens Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytosol
	Molecular Function	Microtubule Motor Activity ATP Binding Microtubule Binding ATPase Activity	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity
	Biological Process	Microtubule-based Movement Golgi Organization Visual Perception Metabolic Process Zonula Adherens Maintenance Epithelial Cell-cell Adhesion	Energy Reserve Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Autophagy Response To Stress Organelle Organization Mitochondrion Organization Cell Cycle Arrest Signal Transduction Insulin Receptor Signaling Pathway Lipid Biosynthetic Process Positive Regulation Of Autophagy Wnt Signaling Pathway Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Histone-serine Phosphorylation Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Membrane Organization Regulation Of Energy Homeostasis
Pathways			Organelle biogenesis and maintenance Integration of energy metabolism Metabolism of lipids and lipoproteins Regulation of Rheb GTPase activity by AMPK IRS-mediated signalling mTOR signalling Translocation of GLUT4 to the plasma membrane Import of palmitoyl-CoA into the mitochondrial matrix mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade Signaling by Insulin receptor Fatty acid, triacylglycerol, and ketone body metabolism Insulin receptor signalling cascade Regulation of AMPK activity via LKB1 IRS-related events Mitochondrial biogenesis IRS-mediated signalling Activation of PPARGC1A (PGC-1alpha) by phosphorylation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS			Lymphocyte counts ( 22286170)
Protein-Protein Interactions		91 interactors: ABI2 AES ANXA13 APP ARNT2 ATF2 BCL6 C1orf109 CBX8 CCDC102B CCDC136 CCDC28A CCDC33 CCDC67 CDK18 CDR2 CEP170P1 CEP55 CEP57L1 CLIP4 CREB5 CYTH4 DCTN2 DCX DTNBP1 ESRRG FAM124A FANCL FCHSD2 GMCL1 GOLGA2 GORASP2 HAUS1 HSBP1 ICA1L ITGB3BP KANSL1 KDM1A KRT15 KRT19 KRT31 KRT40 KRT5 KRT6A KRT6B KRT6C LENG1 LIN37 LZTS2 MCM7 MED4 MFAP1 MID2 MOS NDEL1 NECAB2 NEDD4 NEDD4L NEFL NUP62 PHC2 PRKAA2 PSMB1 RAD51D RSPH14 SCEL SIAH1 SMARCE1 SNAP29 SOX30 SOX5 SPERT SVIL SYCE1 TCEANC TNIP1 TPM3 TRAF2 TRIM23 TRIM27 TRIM41 TRIM54 TSG101 TSR2 USP2 ZBTB8A ZGPAT ZNF180 ZNF20 ZNF572 ZNF655	48 interactors: ABI2 ACACA ACACB AES AIMP2 APPBP2 C19orf47 CCNB1IP1 EEF2K EPM2A FOS GLI1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NL NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAB2 PRKAG1 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 VPS52 WWP1 ZBTB8A ZNF397
Entrez ID		3801	5563
HPRD ID		05171	02735
Ensembl ID		ENSG00000140859	ENSG00000162409
Uniprot IDs		B7Z484 B7Z896 F5H4I9 Q9BVG8	P54646
PDB IDs		2H58	2H6D 2LTU 2YZA 3AQV
Enriched GO Terms of Interacting Partners?		Cell Cycle Organelle Organization Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Gene Expression Regulation Of RNA Metabolic Process Mitotic Cell Cycle RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Gene Expression Cytoskeleton Organization Mitotic Cell Cycle Process RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Developmental Process Axon Cargo Transport Microtubule-based Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Macromolecule Biosynthetic Process Cellular Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Protein Binding Regulation Of Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Protein K63-linked Ubiquitination Retrograde Axon Cargo Transport Protein Polyubiquitination Anatomical Structure Development Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Chromosome Organization Protein Monoubiquitination Cellular Nitrogen Compound Metabolic Process Reproduction Heterocycle Metabolic Process Microtubule Cytoskeleton Organization Cellular Aromatic Compound Metabolic Process	Energy Reserve Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Insulin Receptor Signaling Pathway Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Carnitine Shuttle Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Response To Insulin Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Carnitine Transmembrane Transport Energy Derivation By Oxidation Of Organic Compounds Macromolecule Biosynthetic Process Carnitine Transport Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Gene Expression Cellular Response To Insulin Stimulus Negative Regulation Of Biosynthetic Process RNA Metabolic Process Malonyl-CoA Biosynthetic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Quaternary Ammonium Group Transport Regulation Of Carbohydrate Metabolic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Peptide Hormone Heterocycle Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Fatty Acid Metabolic Process Response To Peptide Cellular Response To Peptide Regulation Of Insulin Secretion Glucose Homeostasis Response To Hormone Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		18b 20b 5b ancca atad2 bromodomain concerted coregulator deregulation drives impeded kif10 kif11 kif15 kif18a kif1a kif1c kif20a kif21 kif23 kif24 kif25 kif4a kif5a kif7 kifc1 kinesin kinesins mll1	amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172
Tagcloud (Difference) ?		18b 20b 5b ancca atad2 bromodomain concerted coregulator deregulation drives impeded kif10 kif11 kif15 kif18a kif1a kif1c kif20a kif21 kif23 kif24 kif25 kif4a kif5a kif7 kifc1 kinesin kinesins mll1	amyloidogenesis apmk appswe arc biogenesis functionality igf1 igf2 igfbp2 igfr impairments insoluble insr intolerant irs1 irs2 nrf1 oxphos pampk pgc pgc1 plaque precede ps1 ps1de9 reinforce sensors tfam thr172
Tagcloud (Intersection) ?