KHK and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KHK	APPBP2
Description		ketohexokinase	amyloid beta precursor protein binding protein 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Membrane Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Ketohexokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Fructose Binding	Microtubule Motor Activity Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Fructose Metabolic Process Response To Sucrose Response To Glucose Response To Fructose Response To Zinc Ion Response To Insulin Carbohydrate Phosphorylation Regulation Of Glycogen Metabolic Process	Intracellular Protein Transport Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport
Pathways		Essential fructosuria Fructose catabolism
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Self-reported risk-taking behaviour ( 30181555) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		4 interacting genes: APPBP2 GLP1R LHX2 LHX9	122 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ASCC3 ATP13A1 BCL7A BIN2 C1orf50 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MGAT4B MLLT3 MMP28 MRPL28 MSH2 MSLN MUL1 MYLK NFYA NHERF1 NPRL3 PCSK5 PEX39 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC33A2 SLC7A10 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		3795	10513
HPRD ID		11774	05616
Ensembl ID		ENSG00000138030	ENSG00000062725
Uniprot IDs		A0A140VJM6 C9JDL1 P50053	Q92624
PDB IDs		2HLZ 2HQQ 2HW1 3B3L 3NBV 3NBW 3NC2 3NC9 3NCA 3Q92 3QA2 3QAI 3RO4 5WBM 5WBO 5WBP 5WBQ 5WBR 5WBZ 6UL7 6W0N 6W0W 6W0X 6W0Y 6W0Z 8OME 8OMF 8OMJ 8OMK 8UG1 8UG3 9FHD 9FHE	8JAL 8JAQ 8JAR 8JAS 8JAU 8JAV
Enriched GO Terms of Interacting Partners?		Glucagon-like Peptide 1 Receptor Activity Gonad Morphogenesis Dorsal Spinal Cord Interneuron Anterior Axon Guidance Spinal Cord Interneuron Axon Guidance Glucagon Receptor Activity Interneuron Axon Guidance Neuron Projection Guidance Axon Guidance Response To Psychosocial Stress Maintenance Of Epithelial Cell Apical/basal Polarity Telencephalon Regionalization Anterior/posterior Axon Guidance Post-translational Protein Targeting To Membrane, Translocation Cellular Response To Glucagon Stimulus Neuron Differentiation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Activation Of Adenylate Cyclase Activity Maintenance Of Cell Polarity Positive Regulation Of Lyase Activity Positive Regulation Of Adenylate Cyclase Activity Response To Glucagon Sequence-specific DNA Binding Neuron Projection Development Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Cyclase Activity Intracellular Protein Transport Olfactory Bulb Development Female Gonad Development	Protein Binding
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