KCNJ12 and APBA1

Number of citations: 0 (PubMedID 15024025)
Data Source: HPRD (in vitro, in vivo)

		KCNJ12	APBA1
Name		potassium inwardly rectifying channel subfamily J member 12	amyloid beta precursor protein binding family A member 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane T-tubule Monoatomic Ion Channel Complex	Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Membrane Dendritic Spine Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding Metal Ion Binding	Amyloid-beta Binding Protein Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Homotetramerization Potassium Ion Import Across Plasma Membrane	In Utero Embryonic Development Intracellular Protein Transport Cell Adhesion Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Axo-dendritic Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Protein Transport Multicellular Organism Growth Establishment Of Localization In Cell Protein-containing Complex Assembly Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Dofetilide Ranolazine Ritodrine Miconazole Yohimbine Dronedarone Butamben	None
GWAS		Adult body size ( 32376654 ) Appendicular lean mass ( 33097823 ) Body mass index ( 25673413 28892062 ) Height ( 20881960 31562340 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Immature fraction of reticulocytes ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Red blood cell count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Waist-hip ratio ( 25673412 )	Cognitive ability ( 29186694 ) Cognitive ability (MTAG) ( 29186694 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Extremely high intelligence ( 29520040 ) Intelligence ( 28530673 ) Intelligence (MTAG) ( 29326435 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Refractive error ( 32231278 )
Interacting Genes		18 interacting genes: ABLIM1 APBA1 CASK CAV3 DLG1 DLG2 DLG3 DLG4 DMD DTNA EMD LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2	18 interacting genes: APP ARF3 ARF4 CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1 TJAP1
Entrez ID		3768	320
HPRD ID		09083	03879
Ensembl ID		ENSG00000184185	ENSG00000107282
Uniprot IDs		Q14500	Q02410
PDB IDs		Not available	1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N
GO Terms Enriched among Interactors		Neuromuscular Junction Dystrophin-associated Glycoprotein Complex MPP7-DLG1-LIN7 Complex Postsynaptic Density Membrane Synapse L27 Domain Binding Sarcolemma Basolateral Plasma Membrane Muscle System Process Intracellular Protein Localization PDZ Domain Binding Ionotropic Glutamate Receptor Binding Synaptic Signaling Plasma Membrane Cell-cell Junction Muscle Contraction Regulation Of Sodium Ion Transmembrane Transport GMP Kinase Activity Anchoring Junction Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Communication Bicellular Tight Junction GDP Metabolic Process Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Nitric-oxide Synthase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse System Process Chemical Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Trans-synaptic Signaling Regulation Of Metal Ion Transport Regulation Of Cardiac Muscle Contraction Cell-cell Signaling Regulation Of Heart Contraction Protein Localization To Cell Junction Actin Binding Signaling Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction GMP Metabolic Process Postsynaptic Membrane Kinase Binding Regulation Of Heart Rate Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Syntrophin Complex	Modulation Of Chemical Synaptic Transmission Plasma Membrane Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Synapse Regulation Of Regulated Secretory Pathway Presynaptic Membrane Positive Regulation Of Synaptic Transmission Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle-mediated Transport Positive Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Establishment Of Protein Localization Regulation Of Neurotransmitter Secretion Intracellular Protein Localization Neurotransmitter Transport Positive Regulation Of Excitatory Postsynaptic Potential Protein Transport Calcium-ion Regulated Exocytosis Regulation Of Synaptic Transmission, GABAergic Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Cellular Localization Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Vesicle-mediated Transport Neurotransmitter Secretion Regulation Of Transport Regulation Of Synapse Organization Intracellular Transport Chemical Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Cell Adhesion Regulation Of System Process Glutamatergic Synapse Positive Regulation Of Regulated Secretory Pathway Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Trans-synaptic Signaling Signal Release Synaptic Signaling Regulation Of Secretion Response To Amyloid-beta Positive Regulation Of ERK1 And ERK2 Cascade Secretion By Cell Exocytosis Regulation Of Synaptic Vesicle Priming Regulation Of Synaptic Transmission, Glutamatergic SNARE Complex Assembly Regulation Of Amine Transport