APBA1 and CACNA1B

Number of citations of the paper that reports this interaction (PubMedID 12177192)
68

Data Source:
HPRD (in vivo, two hybrid)

		APBA1	CACNA1B
Description		amyloid beta precursor protein binding family A member 1	calcium voltage-gated channel subunit alpha1 B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Membrane Dendritic Spine Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Neuronal Cell Body Synapse
	Molecular Function	Amyloid-beta Binding Protein Binding	Nucleotide Binding Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding ATP Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding
	Biological Process	In Utero Embryonic Development Intracellular Protein Transport Cell Adhesion Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Axo-dendritic Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Protein Transport Multicellular Organism Growth Establishment Of Localization In Cell Protein-containing Complex Assembly Presynaptic Modulation Of Chemical Synaptic Transmission	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Response To Amyloid-beta
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Presynaptic depolarization and calcium channel opening
Drugs			Eptifibatide Ergocalciferol Enflurane Amlodipine Amlodipine Spironolactone Nicardipine Verapamil Verapamil Gabapentin Levetiracetam Seletracetam Contulakin-G Ziconotide Agmatine Benidipine Cilnidipine Efonidipine Butamben Bioallethrin
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Refractive error ( 32231278)	Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Bipolar disorder ( 31043756) Body mass index ( 28552196) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Parkinson's disease ( 32201043) Weight ( 28552196)
Interacting Genes		18 interacting genes: APP ARF3 ARF4 CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1 TJAP1	10 interacting genes: APBA1 CACNB3 CAMK2A GNAO1 GNB1 PDLIM5 PPM1A RGS12 RIMS1 RXRB
Entrez ID		320	774
HPRD ID		03879	03005
Ensembl ID		ENSG00000107282	ENSG00000148408
Uniprot IDs		Q02410	Q00975
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N	2LCM 7MIX 7MIY 7VFS 7VFU 7VFV 7VFW
Enriched GO Terms of Interacting Partners?		Modulation Of Chemical Synaptic Transmission Plasma Membrane Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Synapse Regulation Of Regulated Secretory Pathway Presynaptic Membrane Positive Regulation Of Synaptic Transmission Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle-mediated Transport Positive Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Establishment Of Protein Localization Regulation Of Neurotransmitter Secretion Intracellular Protein Localization Neurotransmitter Transport Positive Regulation Of Excitatory Postsynaptic Potential Protein Transport Calcium-ion Regulated Exocytosis Regulation Of Synaptic Transmission, GABAergic Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Cellular Localization Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Vesicle-mediated Transport Neurotransmitter Secretion Regulation Of Transport Regulation Of Synapse Organization Intracellular Transport Chemical Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Cell Adhesion Regulation Of System Process Glutamatergic Synapse Positive Regulation Of Regulated Secretory Pathway Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Trans-synaptic Signaling Signal Release Synaptic Signaling Regulation Of Secretion Response To Amyloid-beta Positive Regulation Of ERK1 And ERK2 Cascade Secretion By Cell Exocytosis Regulation Of Synaptic Vesicle Priming Regulation Of Synaptic Transmission, Glutamatergic SNARE Complex Assembly Regulation Of Amine Transport	Synapse Modulation Of Chemical Synaptic Transmission G Protein-coupled Dopamine Receptor Signaling Pathway GTPase Regulator Activity Heterotrimeric G-protein Complex Cytosol Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Transport Positive Regulation Of High Voltage-gated Calcium Channel Activity Peptidyl-threonine Autophosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion Mu-type Opioid Receptor Binding Membrane Docking GTPase Activity Vesicle Docking Organelle Localization By Membrane Tethering Regulation Of Endocannabinoid Signaling Pathway G Protein-coupled Serotonin Receptor Binding Cytoplasm Dendrite Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity N-terminal Protein Myristoylation Dendritic Spine Gamma-aminobutyric Acid Secretion Intracellular Protein Transport Positive Regulation Of Voltage-gated Calcium Channel Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Presynaptic Membrane Calmodulin-dependent Protein Phosphatase Activity Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Acrosomal Vesicle Exocytosis Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Secretion By Cell Glutamate Receptor Binding Cell Projection Retinoic Acid-responsive Element Binding Structural Constituent Of Presynaptic Active Zone Modulation Of Inhibitory Postsynaptic Potential
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