KCNJ12 and DMD

Number of citations of the paper that reports this interaction (PubMedID 15024025)
0

Data Source:
HPRD (in vitro, in vivo)

		KCNJ12	DMD
Description		potassium inwardly rectifying channel subfamily J member 12	dystrophin
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane T-tubule Monoatomic Ion Channel Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Surface Actin Cytoskeleton Dystrophin-associated Glycoprotein Complex Syntrophin Complex Membrane Lateral Plasma Membrane Myofibril Z Disc Cell-substrate Junction Filopodium Filopodium Membrane Protein-containing Complex Sarcolemma Costamere Neuron Projection Terminus Membrane Raft Synapse Postsynaptic Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding Metal Ion Binding	Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Metal Ion Binding Nitric-oxide Synthase Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Homotetramerization Potassium Ion Import Across Plasma Membrane	Regulation Of Heart Rate Muscle Contraction Cytoskeleton Organization Muscle Organ Development Skeletal Muscle Tissue Development Intracellular Protein Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Maintenance Of Blood-brain Barrier Response To Muscle Stretch Peptide Biosynthetic Process Regulation Of System Process Motile Cilium Assembly Positive Regulation Of Neuron Differentiation Muscle Cell Cellular Homeostasis Neuron Development Muscle Cell Development Cardiac Muscle Contraction Protein-containing Complex Assembly Cardiac Muscle Cell Action Potential Regulation Of Muscle System Process Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Non-integrin membrane-ECM interactions Striated Muscle Contraction Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Dofetilide Ranolazine Ritodrine Miconazole Yohimbine Dronedarone Butamben	Golodirsen
Diseases			Dilated cardiomyopathy (DCM) Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM)
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Height ( 20881960 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip ratio ( 25673412)	Ankle-brachial index ( 31388106) Anxiety in major depressive disorder ( 24047446) Body mass index ( 28892062) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Major depressive disorder ( 34099189) Mild influenza (H1N1) infection ( 26379185) Response to anti-depressant treatment in major depressive disorder ( 22041458) Temporomandibular joint disorder ( 28081371) Waist circumference ( 28552196)
Interacting Genes		18 interacting genes: ABLIM1 APBA1 CASK CAV3 DLG1 DLG2 DLG3 DLG4 DMD DTNA EMD LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2	32 interacting genes: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG FOXP1 HAUS1 HNF4A KCNJ12 KRT19 KRT8 MAP3K5 PGM5 PICK1 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 TRIM63 USP7 UTRN
Entrez ID		3768	1756
HPRD ID		09083	02303
Ensembl ID		ENSG00000184185	ENSG00000198947
Uniprot IDs		Q14500	A0A087WV90 A0A0S2Z3B5 A0A0S2Z3J7 A0A5H1ZRP9 A0A5H1ZRQ1 A0A5H1ZRQ8 A0A5H1ZRR9 A0A804HKY9 A7E212 P11532 Q16484 Q4G0X0
PDB IDs			1DXX 1EG3 1EG4 3UUN 9D58
Enriched GO Terms of Interacting Partners?		Neuromuscular Junction Dystrophin-associated Glycoprotein Complex MPP7-DLG1-LIN7 Complex Postsynaptic Density Membrane Synapse L27 Domain Binding Sarcolemma Basolateral Plasma Membrane Muscle System Process Intracellular Protein Localization PDZ Domain Binding Ionotropic Glutamate Receptor Binding Synaptic Signaling Plasma Membrane Cell-cell Junction Muscle Contraction Regulation Of Sodium Ion Transmembrane Transport GMP Kinase Activity Anchoring Junction Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Communication Bicellular Tight Junction GDP Metabolic Process Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Nitric-oxide Synthase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse System Process Chemical Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Trans-synaptic Signaling Regulation Of Metal Ion Transport Regulation Of Cardiac Muscle Contraction Cell-cell Signaling Regulation Of Heart Contraction Protein Localization To Cell Junction Actin Binding Signaling Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction GMP Metabolic Process Postsynaptic Membrane Kinase Binding Regulation Of Heart Rate Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Syntrophin Complex	Dystrophin-associated Glycoprotein Complex Sarcolemma Cytoskeleton Muscle Contraction Muscle System Process Syntrophin Complex Structural Molecule Activity Synapse Cytoplasm Actin Binding Costamere Filopodium Cell Body PDZ Domain Binding Mesenchyme Migration Skeletal Muscle Thin Filament Assembly Protein-containing Complex Contractile Ring Dense Core Granule Exocytosis Intermediate Filament Cytoskeleton Z Disc Cell Communication Positive Regulation Of Cell-matrix Adhesion System Process Glial Cell Development Vinculin Binding Ciliary Basal Body Lamellipodium Synaptic Signaling Regulation Of Transport Regulation Of System Process Glutamatergic Synapse Secretory Granule Localization Programmed Necrotic Cell Death Heart Contraction Cell-cell Signaling Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development Presynapse Myosin Binding Signaling Focal Adhesion Plasma Membrane Actomyosin Structure Organization Positive Regulation Of Receptor Internalization Cellular Response To Nutrient Levels Myofibril Assembly Heart Process Organelle Assembly Amyloid-beta Complex
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