KCNJ12

Description		potassium inwardly rectifying channel subfamily J member 12
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane T-tubule Monoatomic Ion Channel Complex
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Homotetramerization Potassium Ion Import Across Plasma Membrane
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Dofetilide Ranolazine Ritodrine Miconazole Yohimbine Dronedarone Butamben
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Height ( 20881960 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip ratio ( 25673412)
Interacting Genes		18 interacting genes: ABLIM1 APBA1 CASK CAV3 DLG1 DLG2 DLG3 DLG4 DMD DTNA EMD LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2
Entrez ID		3768
HPRD ID		09083
Ensembl ID		ENSG00000184185
Uniprot IDs		Q14500
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuromuscular Junction Dystrophin-associated Glycoprotein Complex MPP7-DLG1-LIN7 Complex Postsynaptic Density Membrane Synapse L27 Domain Binding Sarcolemma Basolateral Plasma Membrane Muscle System Process Intracellular Protein Localization PDZ Domain Binding Ionotropic Glutamate Receptor Binding Synaptic Signaling Plasma Membrane Cell-cell Junction Muscle Contraction Regulation Of Sodium Ion Transmembrane Transport GMP Kinase Activity Anchoring Junction Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Communication Bicellular Tight Junction GDP Metabolic Process Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Nitric-oxide Synthase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse System Process Chemical Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Trans-synaptic Signaling Regulation Of Metal Ion Transport Regulation Of Cardiac Muscle Contraction Cell-cell Signaling Regulation Of Heart Contraction Protein Localization To Cell Junction Actin Binding Signaling Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction GMP Metabolic Process Postsynaptic Membrane Kinase Binding Regulation Of Heart Rate Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Syntrophin Complex
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