KCNJ12 and DTNA

Number of citations of the paper that reports this interaction (PubMedID 15024025)
0

Data Source:
HPRD (in vitro, in vivo)

		KCNJ12	DTNA
Description		potassium inwardly rectifying channel subfamily J member 12	dystrobrevin alpha
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane T-tubule Monoatomic Ion Channel Complex	Nucleoplasm Cytoplasm Plasma Membrane Membrane Cell Junction Axon Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Sarcolemma Cell Projection Intermediate Filament Cytoskeleton Synapse
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding Metal Ion Binding	Protein Binding Zinc Ion Binding PDZ Domain Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Homotetramerization Potassium Ion Import Across Plasma Membrane	Striated Muscle Contraction Signal Transduction Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Synaptic Signaling
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Dofetilide Ranolazine Ritodrine Miconazole Yohimbine Dronedarone Butamben
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Height ( 20881960 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip ratio ( 25673412)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) PR interval ( 32439900) Urate levels in overweight individuals ( 25811787)
Interacting Genes		18 interacting genes: ABLIM1 APBA1 CASK CAV3 DLG1 DLG2 DLG3 DLG4 DMD DTNA EMD LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2	16 interacting genes: ACTA1 APPL1 DMD DRP2 DTNBP1 GFI1B KCNJ12 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 STAT3 SYNC SYNM UTRN
Entrez ID		3768	1837
HPRD ID		09083	03141
Ensembl ID		ENSG00000184185	ENSG00000134769
Uniprot IDs		Q14500	A0A7P0T9L1 A0A7P0TBH9 A0A7P0Z4D7 B7Z3X3 Q9Y4J8
PDB IDs			2E5R
Enriched GO Terms of Interacting Partners?		Neuromuscular Junction Dystrophin-associated Glycoprotein Complex MPP7-DLG1-LIN7 Complex Postsynaptic Density Membrane Synapse L27 Domain Binding Sarcolemma Basolateral Plasma Membrane Muscle System Process Intracellular Protein Localization PDZ Domain Binding Ionotropic Glutamate Receptor Binding Synaptic Signaling Plasma Membrane Cell-cell Junction Muscle Contraction Regulation Of Sodium Ion Transmembrane Transport GMP Kinase Activity Anchoring Junction Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Communication Bicellular Tight Junction GDP Metabolic Process Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Nitric-oxide Synthase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse System Process Chemical Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Trans-synaptic Signaling Regulation Of Metal Ion Transport Regulation Of Cardiac Muscle Contraction Cell-cell Signaling Regulation Of Heart Contraction Protein Localization To Cell Junction Actin Binding Signaling Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction GMP Metabolic Process Postsynaptic Membrane Kinase Binding Regulation Of Heart Rate Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Syntrophin Complex	Dystrophin-associated Glycoprotein Complex Sarcolemma Syntrophin Complex Muscle Contraction Muscle System Process Actin Binding Vinculin Binding Structural Molecule Activity Cytoskeleton Regulation Of Sodium Ion Transmembrane Transport System Process Regulation Of Sodium Ion Transport Protein-containing Complex Filopodium Nitric-oxide Synthase Binding Neuromuscular Junction PDZ Domain Binding Plasma Membrane Costamere Structural Constituent Of Cytoskeleton Regulation Of Monoatomic Ion Transmembrane Transport Synapse Filopodium Membrane Myosin Binding Regulation Of Transport Positive Regulation Of Endocytosis Anchoring Junction Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Monoatomic Ion Transport Cardiac Muscle Cell Action Potential Structural Constituent Of Muscle Calmodulin Binding Regulation Of Heart Contraction Fast-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cytoplasm Postsynaptic Membrane Regulation Of Blood Circulation Lateral Plasma Membrane Regulation Of Monoatomic Cation Transmembrane Transport Postsynaptic Density Glutamatergic Synapse Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Neurofilament Cytoskeleton Positive Regulation Of Macropinocytosis Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Actin Cytoskeleton Signaling Striated Muscle Contraction Cell Communication
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