APBA1 and KIF17

Number of citations of the paper that reports this interaction (PubMedID 12514209)
43

Data Source:
HPRD (in vivo)

		APBA1	KIF17
Description		amyloid beta precursor protein binding family A member 1	kinesin family member 17
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Membrane Dendritic Spine Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Microtubule Organizing Center Cytosol Cytoskeleton Kinesin Complex Microtubule Cilium Axoneme Microtubule Cytoskeleton Dendrite Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Basal Body Cell Projection Neuron Projection Postsynapse Periciliary Membrane Compartment
	Molecular Function	Amyloid-beta Binding Protein Binding	Nucleotide Binding Microtubule Motor Activity ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity
	Biological Process	In Utero Embryonic Development Intracellular Protein Transport Cell Adhesion Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Axo-dendritic Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Protein Transport Multicellular Organism Growth Establishment Of Localization In Cell Protein-containing Complex Assembly Presynaptic Modulation Of Chemical Synaptic Transmission	Microtubule-based Process Microtubule-based Movement Protein Transport Vesicle-mediated Transport Cell Projection Organization Protein-containing Complex Localization Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Intraflagellar transport Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Refractive error ( 32231278)	Ceramide levels (C24:0) ( 32489964) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Type 1 diabetes (age at diagnosis) ( 33179336)
Interacting Genes		18 interacting genes: APP ARF3 ARF4 CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1 TJAP1	8 interacting genes: APBA1 FHL5 FXR1 GFI1B MAP3K10 MAP3K11 PHAF1 XPO1
Entrez ID		320	57576
HPRD ID		03879	10388
Ensembl ID		ENSG00000107282	ENSG00000117245
Uniprot IDs		Q02410	A0A0A0MRS8 Q9P2E2
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N
Enriched GO Terms of Interacting Partners?		Modulation Of Chemical Synaptic Transmission Plasma Membrane Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Synapse Regulation Of Regulated Secretory Pathway Presynaptic Membrane Positive Regulation Of Synaptic Transmission Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle-mediated Transport Positive Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Establishment Of Protein Localization Regulation Of Neurotransmitter Secretion Intracellular Protein Localization Neurotransmitter Transport Positive Regulation Of Excitatory Postsynaptic Potential Protein Transport Calcium-ion Regulated Exocytosis Regulation Of Synaptic Transmission, GABAergic Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Cellular Localization Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Vesicle-mediated Transport Neurotransmitter Secretion Regulation Of Transport Regulation Of Synapse Organization Intracellular Transport Chemical Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Cell Adhesion Regulation Of System Process Glutamatergic Synapse Positive Regulation Of Regulated Secretory Pathway Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Trans-synaptic Signaling Signal Release Synaptic Signaling Regulation Of Secretion Response To Amyloid-beta Positive Regulation Of ERK1 And ERK2 Cascade Secretion By Cell Exocytosis Regulation Of Synaptic Vesicle Priming Regulation Of Synaptic Transmission, Glutamatergic SNARE Complex Assembly Regulation Of Amine Transport	JUN Kinase Kinase Kinase Activity Positive Regulation Of JUN Kinase Activity MAP Kinase Kinase Kinase Activity Positive Regulation Of MAP Kinase Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Protein Serine/threonine Kinase Activity JNK Cascade Regulation Of MAP Kinase Activity Cellular Localization Dendritic Spine Regulation Of Macromolecule Metabolic Process Gamma-aminobutyric Acid Secretion Positive Regulation Of Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of RNA Metabolic Process Protein Autophosphorylation Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of JNK Cascade Protein Homodimerization Activity Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Annulate Lamellae Cellular Response To Salt Ribosomal Small Subunit Export From Nucleus Response To Triglyceride Ribosomal Large Subunit Export From Nucleus MRNA Transport Cellular Response To Triglyceride RNA Transport RNA Strand Annealing Activity Nuclear Pore Localization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intracellular Membraneless Organelle Regulation Of Metabolic Process Nucleobase-containing Compound Transport Nuclear Envelope Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation MAPK Cascade Mitogen-activated Protein Kinase Kinase Binding Nuclear Export Signal Receptor Activity Ribosomal Subunit Export From Nucleus Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Nuclear Pore Complex Assembly Positive Regulation Of Phosphorylation Regulation Of Kinase Activity
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