APBA1 and TJAP1

Number of citations of the paper that reports this interaction (PubMedID 38072052)
120

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		APBA1	TJAP1
Description		amyloid beta precursor protein binding family A member 1	tight junction associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Membrane Dendritic Spine Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Bicellular Tight Junction Membrane Anchoring Junction
	Molecular Function	Amyloid-beta Binding Protein Binding	Protein Binding
	Biological Process	In Utero Embryonic Development Intracellular Protein Transport Cell Adhesion Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Axo-dendritic Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Protein Transport Multicellular Organism Growth Establishment Of Localization In Cell Protein-containing Complex Assembly Presynaptic Modulation Of Chemical Synaptic Transmission	Golgi Organization
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Refractive error ( 32231278)	PR interval in Tripanosoma cruzi seropositivity ( 24324551) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: APP ARF3 ARF4 CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1 TJAP1	7 interacting genes: APBA1 DLG1 DLG4 GOLGA6L9 KRT75 MEOX2 TRIM54
Entrez ID		320	93643
HPRD ID		03879	10269
Ensembl ID		ENSG00000107282	ENSG00000137221
Uniprot IDs		Q02410	Q5JTD0
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N
Enriched GO Terms of Interacting Partners?		Modulation Of Chemical Synaptic Transmission Plasma Membrane Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Synapse Regulation Of Regulated Secretory Pathway Presynaptic Membrane Positive Regulation Of Synaptic Transmission Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle-mediated Transport Positive Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Establishment Of Protein Localization Regulation Of Neurotransmitter Secretion Intracellular Protein Localization Neurotransmitter Transport Positive Regulation Of Excitatory Postsynaptic Potential Protein Transport Calcium-ion Regulated Exocytosis Regulation Of Synaptic Transmission, GABAergic Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Cellular Localization Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Vesicle-mediated Transport Neurotransmitter Secretion Regulation Of Transport Regulation Of Synapse Organization Intracellular Transport Chemical Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Cell Adhesion Regulation Of System Process Glutamatergic Synapse Positive Regulation Of Regulated Secretory Pathway Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Trans-synaptic Signaling Signal Release Synaptic Signaling Regulation Of Secretion Response To Amyloid-beta Positive Regulation Of ERK1 And ERK2 Cascade Secretion By Cell Exocytosis Regulation Of Synaptic Vesicle Priming Regulation Of Synaptic Transmission, Glutamatergic SNARE Complex Assembly Regulation Of Amine Transport	Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Ionotropic Glutamate Receptor Binding Chemical Synaptic Transmission Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Trans-synaptic Signaling Protein Localization To Synapse Synaptic Signaling Synaptic Membrane Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels P2Y1 Nucleotide Receptor Binding Neuromuscular Junction Protein Localization To Cell Junction Kinase Binding Postsynaptic Density Membrane Nervous System Development Glutamatergic Synapse Structural Constituent Of Postsynaptic Density L27 Domain Binding Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Synaptic Vesicle Cell-cell Signaling Cell Communication Dendritic Spine Signaling MPP7-DLG1-LIN7 Complex Maintenance Of Postsynaptic Density Structure Lateral Loop Myelin Sheath Abaxonal Region Muscle Tissue Development Establishment Or Maintenance Of Cell Polarity AMPA Glutamate Receptor Clustering Neuroligin Family Protein Binding Somite Specification Gamma-aminobutyric Acid Secretion Regulation Of Potassium Ion Import Adherens Junction NMDA Selective Glutamate Receptor Signaling Pathway Locomotory Behavior Cell Junction D1 Dopamine Receptor Binding Microtubule-based Process Cerebellar Mossy Fiber Synaptic Vesicle Maturation
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