APBA1 and KCNJ12

Number of citations of the paper that reports this interaction (PMID 14960569)
32

Data Source:
HPRD (in vivo, in vitro)

		APBA1	KCNJ12
Gene Name		amyloid beta (A4) precursor protein-binding, family A, member 1	potassium channel, inwardly rectifying subfamily J, member 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Synaptic Vesicle Protein Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Membrane
	Molecular Function	Beta-amyloid Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding PDZ Domain Binding Protein Complex Binding	Inward Rectifier Potassium Channel Activity
	Biological Process	In Utero Embryonic Development Protein Complex Assembly Intracellular Protein Transport Cell Adhesion Synaptic Transmission Nervous System Development Locomotory Behavior Axon Cargo Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Multicellular Organism Growth	Potassium Ion Transport Muscle Contraction Synaptic Transmission Regulation Of Heart Contraction Potassium Ion Import Regulation Of Ion Transmembrane Transport Protein Homotetramerization
Pathways			GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs			Dofetilide
Diseases
GWAS			Height ( 20881960)
Protein-Protein Interactions		15 interactors: APP CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1	16 interactors: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2
Entrez ID		320	3768
HPRD ID		03879	09083
Ensembl ID		ENSG00000107282	ENSG00000184185
Uniprot IDs		Q02410	Q14500
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N
Enriched GO Terms of Interacting Partners?		Secretion Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion By Cell Neurotransmitter Transport Cell-cell Signaling Synaptic Transmission Establishment Of Localization In Cell Transport Cellular Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Synaptic Transmission Exocytosis Cell Adhesion Ion Transport Regulation Of Grooming Behavior Metal Ion Transport Vesicle Localization Regulation Of Peptide Hormone Secretion Regulation Of Synaptic Vesicle Priming Establishment Of Protein Localization Dicarboxylic Acid Transport Regulation Of Hormone Secretion Regulation Of Membrane Potential Behavior Regulation Of Secretion Synaptic Vesicle Transport Cation Transport Regulation Of Receptor Activity Membrane Depolarization Notch Receptor Processing Extracellular Matrix Organization Extracellular Structure Organization Protein Localization Notch Signaling Pathway Glutamate Secretion Organelle Localization Regulation Of Ion Transmembrane Transport Regulation Of Exocytosis Amino Acid Transport Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Single-organism Behavior Vesicle-mediated Transport Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Behavior Calcium Ion Import Regulation Of Synaptic Vesicle Exocytosis Regulation Of Signaling	Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Synaptic Transmission Maintenance Of Cell Polarity Nucleotide Phosphorylation Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Protein Localization To Membrane Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Membrane Organization Cellular Protein Localization Receptor Clustering Regulation Of Ion Transmembrane Transport Muscle Contraction Muscle System Process Protein Localization Asymmetric Protein Localization Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Ion Transport Regulation Of Sodium Ion Transmembrane Transport Secretion Protein Localization To Plasma Membrane Cellular Localization Endomembrane System Organization Regulation Of Sodium Ion Transport Plasma Membrane Organization Secretion By Cell Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Movement Of Cell Or Subcellular Component Anatomical Structure Development Nucleotide Metabolic Process Regulation Of Membrane Potential Regulation Of Striated Muscle Contraction Chemotaxis Nervous System Development System Development Nucleobase-containing Small Molecule Metabolic Process Neurotransmitter Secretion Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Exocytosis Developmental Process Signaling Cellular Component Assembly Cell Communication Axon Guidance
Tagcloud ?		abpa1 cask compromised consisting cortical distinctly dysregulated glutamate hypofunction involve kif17 layer mediating microtubule mlin7 mlin7a mlin7c neurotransmission nmda nr2a nr2b overlapped pathophysiology postmortem prominent schizophrenia separate trafficking transcripts
Tagcloud (Difference) ?		abpa1 cask compromised consisting cortical distinctly dysregulated glutamate hypofunction involve kif17 layer mediating microtubule mlin7 mlin7a mlin7c neurotransmission nmda nr2a nr2b overlapped pathophysiology postmortem prominent schizophrenia separate trafficking transcripts
Tagcloud (Intersection) ?