KCNJ12 and ABLIM1

Number of citations of the paper that reports this interaction (PMID 15024025)
29

Data Source:
HPRD (in vitro)

		KCNJ12	ABLIM1
Gene Name		potassium channel, inwardly rectifying subfamily J, member 12	actin binding LIM protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Membrane	Stress Fiber Cytoplasm Actin Cytoskeleton Lamellipodium
	Molecular Function	Inward Rectifier Potassium Channel Activity	Actin Binding Protein Binding Zinc Ion Binding
	Biological Process	Potassium Ion Transport Muscle Contraction Synaptic Transmission Regulation Of Heart Contraction Potassium Ion Import Regulation Of Ion Transmembrane Transport Protein Homotetramerization	Cytoskeleton Organization Axon Guidance Visual Perception Organ Morphogenesis Lamellipodium Assembly Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses	Axon guidance DCC mediated attractive signaling Netrin-1 signaling
Drugs		Dofetilide
Diseases
GWAS		Height ( 20881960)	Obesity-related traits ( 23251661) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		16 interactors: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2	17 interactors: ACTB ACTG1 APP BEGAIN CALCOCO2 CARD9 GOLGA2 HOOK2 KCNJ12 KRT15 LDOC1 SREBF2 TRAF2 TSC22D4 USHBP1 VIM YWHAG
Entrez ID		3768	3983
HPRD ID		09083	03819
Ensembl ID		ENSG00000184185	ENSG00000099204
Uniprot IDs		Q14500	B3KSG3 B3KVH2 B4DQA3 B7Z4H1 O14639
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Synaptic Transmission Maintenance Of Cell Polarity Nucleotide Phosphorylation Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Protein Localization To Membrane Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Membrane Organization Cellular Protein Localization Receptor Clustering Regulation Of Ion Transmembrane Transport Muscle Contraction Muscle System Process Protein Localization Asymmetric Protein Localization Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Ion Transport Regulation Of Sodium Ion Transmembrane Transport Secretion Protein Localization To Plasma Membrane Cellular Localization Endomembrane System Organization Regulation Of Sodium Ion Transport Plasma Membrane Organization Secretion By Cell Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Movement Of Cell Or Subcellular Component Anatomical Structure Development Nucleotide Metabolic Process Regulation Of Membrane Potential Regulation Of Striated Muscle Contraction Chemotaxis Nervous System Development System Development Nucleobase-containing Small Molecule Metabolic Process Neurotransmitter Secretion Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Exocytosis Developmental Process Signaling Cellular Component Assembly Cell Communication Axon Guidance	Innate Immune Response Immune Response Regulation Of Protein Binding Defense Response Immune Response-regulating Signaling Pathway Platelet Activation Platelet Aggregation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Binding Positive Regulation Of Immune Response Retina Homeostasis Endocytosis Response To Stress Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Adherens Junction Organization Immune System Process Ephrin Receptor Signaling Pathway Collateral Sprouting In Absence Of Injury Axon Guidance Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Blood Coagulation Hemostasis Cholesterol Metabolic Process Generation Of Neurons Positive Regulation Of JNK Cascade Apoptotic Process Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cholesterol Efflux Sterol Metabolic Process Pattern Recognition Receptor Signaling Pathway Neurogenesis Innate Immune Response-activating Signal Transduction Positive Regulation Of Stress-activated MAPK Cascade Programmed Cell Death Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Activation Of Innate Immune Response Cell Death Death Positive Regulation Of Peptidase Activity Axon Choice Point Recognition Negative Regulation Of Glial Cell Apoptotic Process Axonogenesis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway
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