KCNJ12 and LIN7C

Number of citations of the paper that reports this interaction (PubMedID 15024025)
0

Data Source:
HPRD (in vitro, in vivo)

		KCNJ12	LIN7C
Description		potassium inwardly rectifying channel subfamily J member 12	lin-7 cell polarity scaffold C
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane T-tubule Monoatomic Ion Channel Complex	Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding Metal Ion Binding	Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding Protein-macromolecule Adaptor Activity L27 Domain Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Homotetramerization Potassium Ion Import Across Plasma Membrane	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Dofetilide Ranolazine Ritodrine Miconazole Yohimbine Dronedarone Butamben
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Height ( 20881960 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip ratio ( 25673412)	Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Hip circumference ( 25673412) Lumbar spine bone mineral density ( 22504420) Menarche (age at onset) ( 27182965) Morning person ( 30696823) Survival in pancreatic cancer ( 28470677)
Interacting Genes		18 interacting genes: ABLIM1 APBA1 CASK CAV3 DLG1 DLG2 DLG3 DLG4 DMD DTNA EMD LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2	9 interacting genes: ABCA1 BAIAP2 DNAJC5 HTR2C KCNJ12 MPP2 MPP7 SNCA YES1
Entrez ID		3768	55327
HPRD ID		09083	17279
Ensembl ID		ENSG00000184185	ENSG00000148943
Uniprot IDs		Q14500	Q9NUP9
PDB IDs			3LRA
Enriched GO Terms of Interacting Partners?		Neuromuscular Junction Dystrophin-associated Glycoprotein Complex MPP7-DLG1-LIN7 Complex Postsynaptic Density Membrane Synapse L27 Domain Binding Sarcolemma Basolateral Plasma Membrane Muscle System Process Intracellular Protein Localization PDZ Domain Binding Ionotropic Glutamate Receptor Binding Synaptic Signaling Plasma Membrane Cell-cell Junction Muscle Contraction Regulation Of Sodium Ion Transmembrane Transport GMP Kinase Activity Anchoring Junction Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Communication Bicellular Tight Junction GDP Metabolic Process Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Nitric-oxide Synthase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse System Process Chemical Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Trans-synaptic Signaling Regulation Of Metal Ion Transport Regulation Of Cardiac Muscle Contraction Cell-cell Signaling Regulation Of Heart Contraction Protein Localization To Cell Junction Actin Binding Signaling Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction GMP Metabolic Process Postsynaptic Membrane Kinase Binding Regulation Of Heart Rate Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Syntrophin Complex	Positive Regulation Of Protein-containing Complex Assembly Plasma Membrane Regulation Of Transport Regulation Of Protein-containing Complex Assembly Signal Release Positive Regulation Of Cellular Component Biogenesis Regulation Of Synaptic Plasticity Synaptic Vesicle Exocytosis Cellular Response To Retinoic Acid Cellular Component Assembly Sphingolipid Floppase Activity Membrane Protein Complex Oligomerization Long-term Synaptic Potentiation Excitatory Postsynaptic Potential Dendritic Shaft Response To Desipramine Presynapse Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dendritic Spine Cytoplasm Neuron Projection Branch Point Regulation Of Biological Quality Response To Vitamin B3 Secretion By Cell Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Protein Tetramerization Vesicle-mediated Transport In Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Protein Localization To Cell Junction Response To Retinoic Acid Regulation Of Multicellular Organismal Process Regulation Of High-density Lipoprotein Particle Assembly Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Postsynaptic Membrane Potential Regulation Of Membrane Potential Negative Regulation Of Serotonin Uptake Neuron Apoptotic Process Transporter Regulator Activity Regulated Exocytosis Negative Regulation Of Chaperone-mediated Autophagy
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