KCNJ12 and SNTB1

Number of citations of the paper that reports this interaction (PMID 15024025)
29

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		KCNJ12	SNTB1
Gene Name		potassium channel, inwardly rectifying subfamily J, member 12	syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Membrane	Cytoplasm Cytoskeleton Focal Adhesion Dystrophin-associated Glycoprotein Complex Sarcolemma Protein Complex Synapse
	Molecular Function	Inward Rectifier Potassium Channel Activity	Actin Binding Protein Binding Calmodulin Binding PDZ Domain Binding
	Biological Process	Potassium Ion Transport Muscle Contraction Synaptic Transmission Regulation Of Heart Contraction Potassium Ion Import Regulation Of Ion Transmembrane Transport Protein Homotetramerization	Muscle Contraction
Pathways		GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs		Dofetilide
Diseases
GWAS		Height ( 20881960)	Myopia (pathological) ( 23406873)
Protein-Protein Interactions		16 interactors: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2	11 interactors: ABCA1 ADRA1D BAI1 DGKZ DMD DTNA KCNJ12 MAPK12 SCN4A SCN5A UTRN
Entrez ID		3768	6641
HPRD ID		09083	02490
Ensembl ID		ENSG00000184185	ENSG00000172164
Uniprot IDs		Q14500	Q13884
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Synaptic Transmission Maintenance Of Cell Polarity Nucleotide Phosphorylation Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Protein Localization To Membrane Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Membrane Organization Cellular Protein Localization Receptor Clustering Regulation Of Ion Transmembrane Transport Muscle Contraction Muscle System Process Protein Localization Asymmetric Protein Localization Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Ion Transport Regulation Of Sodium Ion Transmembrane Transport Secretion Protein Localization To Plasma Membrane Cellular Localization Endomembrane System Organization Regulation Of Sodium Ion Transport Plasma Membrane Organization Secretion By Cell Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Movement Of Cell Or Subcellular Component Anatomical Structure Development Nucleotide Metabolic Process Regulation Of Membrane Potential Regulation Of Striated Muscle Contraction Chemotaxis Nervous System Development System Development Nucleobase-containing Small Molecule Metabolic Process Neurotransmitter Secretion Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Exocytosis Developmental Process Signaling Cellular Component Assembly Cell Communication Axon Guidance	Muscle Contraction Muscle System Process Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Sodium Ion Transport Regulation Of Ion Transport Signaling Cell Communication Action Potential Striated Muscle Contraction Cell-cell Signaling Regulation Of Sodium Ion Transmembrane Transporter Activity Neuronal Action Potential Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Positive Regulation Of Sodium Ion Transport Regulation Of Membrane Potential Muscle Organ Development Cardiac Muscle Contraction Positive Regulation Of Cell-matrix Adhesion Transmission Of Nerve Impulse Blood Circulation Heart Contraction Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cellular Process Regulation Of Striated Muscle Contraction Establishment Of Glial Blood-brain Barrier Peripheral Nervous System Development Membrane Depolarization Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion G-protein Coupled Receptor Signaling Pathway Muscle Structure Development Negative Regulation Of Peptidyl-cysteine S-nitrosylation Membrane Depolarization During SA Node Cell Action Potential Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Interleukin-1 Beta Secretion Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Synaptic Transmission Ion Transmembrane Transport Regulation Of Muscle Contraction SA Node Cell Action Potential Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Establishment Of Blood-nerve Barrier AV Node Cell To Bundle Of His Cell Communication Cellular Response To Stimulus
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