APBA1 and HTR2C

Number of citations: 52 (PubMedID 12006486)
Data Source: BioGRID (pull down), HPRD (in vivo)

		APBA1	HTR2C
Name		amyloid beta precursor protein binding family A member 1	5-hydroxytryptamine receptor 2C
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Membrane Dendritic Spine Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Plasma Membrane Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex
	Molecular Function	Amyloid-beta Binding Protein Binding	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Serotonin Receptor Activity
	Biological Process	In Utero Embryonic Development Intracellular Protein Transport Cell Adhesion Chemical Synaptic Transmission Nervous System Development Locomotory Behavior Axo-dendritic Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Protein Transport Multicellular Organism Growth Establishment Of Localization In Cell Protein-containing Complex Assembly Presynaptic Modulation Of Chemical Synaptic Transmission	Behavioral Fear Response Intracellular Calcium Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Appetite Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Calcium-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Serotonin receptors G alpha (q) signalling events
Drugs		None	Tramadol Ziprasidone Methysergide Cabergoline Dihydroergotamine Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Flupentixol Cyclobenzaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Lofexidine Pimavanserin Epicept NP-1 Cariprazine Sertindole Mianserin Pizotifen Asenapine Ocaperidone Dotarizine Deramciclane Agomelatine Esmirtazapine Nandrolone decanoate Captodiame Viloxazine Etoperidone Lorpiprazole Setiptiline Dihydroergocornine m-Chlorophenylpiperazine Gilteritinib Sarpogrelate Eplivanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine Aripiprazole lauroxil
GWAS		Cognitive ability ( 29186694 ) Cognitive ability (MTAG) ( 29186694 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Extremely high intelligence ( 29520040 ) Intelligence ( 28530673 ) Intelligence (MTAG) ( 29326435 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Refractive error ( 32231278 )	No GWAS studies recorded
Interacting Genes		18 interacting genes: APP ARF3 ARF4 CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1 TJAP1	34 interacting genes: APBA1 ARLN ARRB2 ATP2B3 ATP6AP2 ATP6V0C CALM1 CBX3 CNIH1 CRELD1 DLG4 EMP1 ERG28 GHITM GJA1 GNAQ GPR37 GPRC5B LIN7C MPDZ PLP1 RTN4 SGCB SLC29A1 SLC39A1 SLC39A9 SLC71A1 SNTA1 SPNS1 TM9SF2 TMBIM6 TMEM147 TMEM94 TPI1
Entrez ID		320	3358
HPRD ID		03879	02429
Ensembl ID		ENSG00000107282	ENSG00000147246
Uniprot IDs		Q02410	K9J958 P28335
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N	6BQG 6BQH 8DPF 8DPG 8DPH 8DPI 8ZMF
GO Terms Enriched among Interactors		Modulation Of Chemical Synaptic Transmission Plasma Membrane Establishment Of Localization In Cell Regulation Of Calcium Ion-dependent Exocytosis Synapse Regulation Of Regulated Secretory Pathway Presynaptic Membrane Positive Regulation Of Synaptic Transmission Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Vesicle-mediated Transport Positive Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Establishment Of Protein Localization Regulation Of Neurotransmitter Secretion Intracellular Protein Localization Neurotransmitter Transport Positive Regulation Of Excitatory Postsynaptic Potential Protein Transport Calcium-ion Regulated Exocytosis Regulation Of Synaptic Transmission, GABAergic Astrocyte Activation Involved In Immune Response Regulation Of Nervous System Process Cellular Localization Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Vesicle-mediated Transport Neurotransmitter Secretion Regulation Of Transport Regulation Of Synapse Organization Intracellular Transport Chemical Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Cell Adhesion Regulation Of System Process Glutamatergic Synapse Positive Regulation Of Regulated Secretory Pathway Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Trans-synaptic Signaling Signal Release Synaptic Signaling Regulation Of Secretion Response To Amyloid-beta Positive Regulation Of ERK1 And ERK2 Cascade Secretion By Cell Exocytosis Regulation Of Synaptic Vesicle Priming Regulation Of Synaptic Transmission, Glutamatergic SNARE Complex Assembly Regulation Of Amine Transport	Membrane Endoplasmic Reticulum Membrane Plasma Membrane Transmembrane Transport Cellular Homeostasis Intracellular Chemical Homeostasis Homeostatic Process Chemical Homeostasis Synapse Monoatomic Ion Transmembrane Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Cation Transmembrane Transport Endoplasmic Reticulum PDZ Domain Binding Monoatomic Cation Transmembrane Transport Ubiquitin Protein Ligase Binding Monoatomic Cation Homeostasis Regulation Of Lysosomal Lumen PH Monoatomic Ion Homeostasis Inorganic Ion Transmembrane Transport Monoatomic Ion Transport D1 Dopamine Receptor Binding Monoatomic Cation Transport Glutamatergic Synapse Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Regulation Of Membrane Potential Neuron Cellular Homeostasis Glutamate Secretion Endosomal Lumen Acidification G Protein-coupled Receptor Binding Dystrophin-associated Glycoprotein Complex Proton-transporting V-type ATPase Complex Synaptic Vesicle Lumen Acidification Regulation Of Intracellular PH Bounding Membrane Of Organelle Regulation Of Cellular PH Regulation Of System Process Metal Ion Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Regulation Of Biological Quality Metal Ion Transport Regulation Of PH Zinc Ion Transmembrane Transporter Activity Positive Regulation Of Macrophage Cytokine Production Postsynapse Lysosomal Lumen Acidification Anchoring Junction Zinc Ion Transmembrane Transport