KCNJ12 and SNTB2

Number of citations of the paper that reports this interaction (PubMedID 15024025)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		KCNJ12	SNTB2
Description		potassium inwardly rectifying channel subfamily J member 12	syntrophin beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane T-tubule Monoatomic Ion Channel Complex	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Focal Adhesion Dystrophin-associated Glycoprotein Complex Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Centriolar Satellite Ciliary Basal Body Synapse Anchoring Junction
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding Metal Ion Binding	RNA Binding Actin Binding Structural Molecule Activity Protein Binding Calmodulin Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Muscle Contraction Regulation Of Heart Contraction Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Homotetramerization Potassium Ion Import Across Plasma Membrane
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Dofetilide Ranolazine Ritodrine Miconazole Yohimbine Dronedarone Butamben
Diseases
GWAS		Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 25673413 28892062) Height ( 20881960 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip ratio ( 25673412)	Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Left-handedness ( 32989287) Logical memory (delayed recall) in normal cognition ( 29274321)
Interacting Genes		18 interacting genes: ABLIM1 APBA1 CASK CAV3 DLG1 DLG2 DLG3 DLG4 DMD DTNA EMD LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2	16 interacting genes: ABCA1 ADGRB1 ADRA1D DGKZ DMD DTNA ERBB4 KCNJ12 MAST1 MAST2 PTEN PTPRN SCN4A SCN5A UBC UTRN
Entrez ID		3768	6645
HPRD ID		09083	02491
Ensembl ID		ENSG00000184185	ENSG00000168807
Uniprot IDs		Q14500	Q13425
PDB IDs			2VRF
Enriched GO Terms of Interacting Partners?		Neuromuscular Junction Dystrophin-associated Glycoprotein Complex MPP7-DLG1-LIN7 Complex Postsynaptic Density Membrane Synapse L27 Domain Binding Sarcolemma Basolateral Plasma Membrane Muscle System Process Intracellular Protein Localization PDZ Domain Binding Ionotropic Glutamate Receptor Binding Synaptic Signaling Plasma Membrane Cell-cell Junction Muscle Contraction Regulation Of Sodium Ion Transmembrane Transport GMP Kinase Activity Anchoring Junction Regulation Of Synaptic Assembly At Neuromuscular Junction Cell Communication Bicellular Tight Junction GDP Metabolic Process Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Nitric-oxide Synthase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse System Process Chemical Synaptic Transmission Regulation Of Sodium Ion Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Trans-synaptic Signaling Regulation Of Metal Ion Transport Regulation Of Cardiac Muscle Contraction Cell-cell Signaling Regulation Of Heart Contraction Protein Localization To Cell Junction Actin Binding Signaling Regulation Of Monoatomic Ion Transport Regulation Of Striated Muscle Contraction GMP Metabolic Process Postsynaptic Membrane Kinase Binding Regulation Of Heart Rate Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Syntrophin Complex	Plasma Membrane Muscle Contraction Muscle System Process Sarcolemma Regulation Of System Process Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Membrane Cell Communication System Process Regulation Of Sodium Ion Transport PDZ Domain Binding Vinculin Binding Striated Muscle Contraction Nitric-oxide Synthase Binding Voltage-gated Sodium Channel Complex Regulation Of Multicellular Organismal Process Regulation Of Blood Circulation Dystrophin-associated Glycoprotein Complex Regulation Of Striated Muscle Contraction Voltage-gated Sodium Channel Activity Synapse Regulation Of Monoatomic Ion Transmembrane Transport Filopodium Membrane Action Potential Regulation Of Skeletal Muscle Contraction Regulation Of Biological Quality Cell-cell Signaling Muscle Organ Development Monoatomic Ion Channel Complex Signaling Synaptic Signaling Muscle Structure Development Regulation Of Transport Phagocytosis, Engulfment Phosphorylation Monoatomic Cation Channel Activity Regulation Of Monoatomic Ion Transport Sodium Channel Activity Regulation Of Muscle Contraction Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Membrane Potential Cell Projection Cardiac Muscle Contraction Membrane Invagination Sphingolipid Floppase Activity Regulation Of Heart Contraction Positive Regulation Of Epithelial Cell Proliferation Establishment Of Planar Polarity Involved In Nephron Morphogenesis T-tubule
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