ITGA7 and FHL2

Number of citations of the paper that reports this interaction (PubMedID 15117962)
0

Data Source:
BioGRID (imaging technique)
HPRD (in vitro, two hybrid)

		ITGA7	FHL2
Description		integrin subunit alpha 7	four and a half LIM domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Z Disc
	Molecular Function	Protein Binding Signaling Receptor Activity Metal Ion Binding	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding BHLH Transcription Factor Binding Metal Ion Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Regulation Of Cell Shape Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Leukocyte Migration Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Response To Hormone Negative Regulation Of Apoptotic Process Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Integrin cell surface interactions Laminin interactions Laminin interactions ECM proteoglycans	PPARA activates gene expression
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278)	Appendicular lean mass ( 33097823) Bipolar disorder x sex interaction ( 34099189) Body fat mass ( 28552196) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) PR interval ( 32439900) Pulse pressure ( 30224653 30578418) Walking pace ( 33128006)
Interacting Genes		5 interacting genes: CHRNA1 FHL2 FHL3 HTRA2 MYOC	175 interacting genes: A1CF ABI1 ABLIM1 ADAM17 AK1 AKIP1 AMOT ANKRD55 APP AR ARHGAP9 ATOSB ATXN1 BANP BARX2 BIN1 BLZF1 BMPR2 BRCA1 CACNA1C CAND2 CAPN1 CARD8 CATSPERT CCDC198 CCDC92 CDC73 CFTR CIMIP1 CKM CREBBP CSK CSN2 CTNNB1 DAPL1 DCP1A DDIT4L DLGAP1 DPF2 DRC4 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FAM204A FHL1 FHL3 FHL5 FOXO1 GATAD2B GLYR1 GMEB2 GNG12 GNG4 GOLGA6A GTF2F2 GTF2H1 HAND1 HCK HSF2BP HSPB2 ID3 IDH1 IER3 IFI35 IGFBP5 IKZF1 IKZF4 IL16 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 KIF5B KLF12 KLHL20 KPRP LDLRAP1 LRIF1 MAGEL2 MBD3L1 MCM7 MDM2 MISP MYBPC1 MYO15B NBPF6 NIBAN1 NRF1 PFKM PHB2 PHF1 PHF21A PKNOX1 PKNOX2 POGZ POU6F2 PRDM11 PRDM6 PRR5L PSEN2 PUF60 QRICH1 RAI2 REL REV1 RFX3 RIPPLY1 RUNX2 SAP30BP SAXO1 SAXO2 SAXO4 SCNM1 SFPQ SH3RF1 SIGLEC6 SLAIN1 SLC34A1 SMAD2 SMAD3 SMAD4 SNAI1 SOX30 SP2 SPRY4 SREBF2 SRF STAT3 SUMO1P1 TCP10L TNFRSF11A TOX3 TRAF6 TRIM55 TRIM63 TRIM73 TTN TXNRD3 VXN WASHC1 WT1 YPEL3 YY1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF143 ZNF200 ZNF212 ZNF23 ZNF3 ZNF331 ZNF408 ZNF410 ZNF417 ZNF620 ZNF626 ZNF638 ZNF655 ZNF85 ZSCAN9
Entrez ID		3679	2274
HPRD ID		02761	04026
Ensembl ID		ENSG00000135424	ENSG00000115641
Uniprot IDs		J3KNV4 Q13683	Q14192 Q2XQU9 Q6I9R8
PDB IDs			1X4K 1X4L 2D8Z 2MIU
Enriched GO Terms of Interacting Partners?		Osteoblast Differentiation Atrial Cardiac Muscle Cell Development Z Disc Mitochondrial Intermembrane Space Skeletal Muscle Hypertrophy Pentacyclic Triterpenoid Metabolic Process Negative Regulation Of Type 2 Mitophagy Negative Regulation Of Intracellular Signal Transduction Muscle Cell Cellular Homeostasis Acetylcholine Binding Muscle System Process Acetylcholine Receptor Activity Regulation Of Cell Communication Skeletal Muscle Tissue Growth Synaptic Transmission, Cholinergic Musculoskeletal Movement Regulation Of Membrane Potential Acetylcholine-gated Monoatomic Cation-selective Channel Activity Regulation Of Signaling Acetylcholine-gated Channel Complex Negative Regulation Of Signal Transduction Negative Regulation Of Calcineurin-NFAT Signaling Cascade Heart Trabecula Formation Focal Adhesion Ventricular Cardiac Muscle Cell Development Negative Regulation Of Calcium-mediated Signaling Transcription Factor Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Membrane Depolarization Node Of Ranvier ERBB2-ERBB3 Signaling Pathway Negative Regulation Of Rho Protein Signal Transduction ERBB3 Signaling Pathway Neuronal Ion Channel Clustering ERBB2 Signaling Pathway Myosin Light Chain Binding Regulation Of Mitochondrial Depolarization Positive Regulation Of Mitochondrial Depolarization Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Myelination In Peripheral Nervous System Positive Regulation Of Execution Phase Of Apoptosis Response To Herbicide Mitochondrial Protein Catabolic Process Ubiquitin Ligase Inhibitor Activity CD40 Receptor Complex Serine-type Endopeptidase Complex Negative Regulation Of Mitophagy Execution Phase Of Apoptosis	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Sequence-specific DNA Binding Zinc Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Positive Regulation Of Metabolic Process Transcription Regulator Complex Metal Ion Binding Regulation Of MiRNA Transcription Sequence-specific Double-stranded DNA Binding Chromatin Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-templated Transcription Formation Of Primary Germ Layer Integrin Complex Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex
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