ITGA7 and FHL2

Number of citations of the paper that reports this interaction (PMID 15117962)
20

Data Source:
BioGRID (imaging technique)
HPRD (two hybrid, in vitro)

		ITGA7	FHL2
Gene Name		integrin, alpha 7	four and a half LIM domains 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Muscle Tendon Junction Cell Surface Neuromuscular Junction Integrin Alpha7-beta1 Complex Sarcolemma	Nucleus Nucleoplasm Focal Adhesion Actin Cytoskeleton Z Disc M Band
	Molecular Function	Integrin Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Identical Protein Binding Androgen Receptor Binding
	Biological Process	Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Skeletal Muscle Tissue Development Regulation Of Cell Shape Cell Migration Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Blood Vessel Morphogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Transcription, DNA-templated Response To Hormone Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation
Pathways		Laminin interactions ECM proteoglycans Integrin cell surface interactions	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CHRNA1 FHL2 FHL3 MYOC	92 interactors: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EIF6 EP300 ESR1 FAM129A FAM154A FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HIF1A ID3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MYBPC1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638
Entrez ID		3679	2274
HPRD ID		02761	04026
Ensembl ID		ENSG00000135424	ENSG00000115641
Uniprot IDs		J3KNV4 Q13683 Q4LE35	J3KNW4 Q14192 Q2XQU9 Q6I9R8
PDB IDs			1X4K 1X4L 2D8Z
Enriched GO Terms of Interacting Partners?		Muscle Structure Development Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Osteoblast Differentiation Organ Development ERBB2 Signaling Pathway Atrial Cardiac Muscle Cell Development Skeletal Muscle Tissue Growth Muscle System Process Muscle Organ Development Ossification Non-canonical Wnt Signaling Pathway Via JNK Cascade System Development Striated Muscle Tissue Development Neuron Cellular Homeostasis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Muscle Tissue Development Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Positive Regulation Of Mitochondrial Depolarization Multicellular Organismal Development Negative Regulation Of Stress Fiber Assembly Anatomical Structure Development Neuronal Ion Channel Clustering Negative Regulation Of Actin Filament Bundle Assembly Heart Trabecula Formation Developmental Process Regulation Of Mitochondrial Depolarization Ventricular Cardiac Muscle Cell Development Negative Regulation Of Rho Protein Signal Transduction Neuromuscular Synaptic Transmission Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Cell Cellular Homeostasis Heart Trabecula Morphogenesis Muscle Hypertrophy Ventricular Cardiac Muscle Cell Differentiation Skeletal Muscle Contraction Neuron Maturation Neuronal Action Potential Non-canonical Wnt Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Membrane Depolarization Negative Regulation Of Cell-matrix Adhesion Androgen Receptor Signaling Pathway Musculoskeletal Movement Positive Regulation Of Stress Fiber Assembly Myelination In Peripheral Nervous System Regulation Of Focal Adhesion Assembly	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Transcription, DNA-templated Biosynthetic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Developmental Process Negative Regulation Of Transcription, DNA-templated Formation Of Primary Germ Layer Negative Regulation Of Cellular Metabolic Process Tissue Development Anatomical Structure Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gastrulation Regulation Of Signaling Anatomical Structure Development Response To Organic Substance Organ Morphogenesis Embryonic Morphogenesis
Tagcloud ?			acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Difference) ?			acted adapter converts cytoplasm cytoskeleton deprived deregulated direction e2 ehd2 enrichment homer3 hydroxytamoxifen mcf modulator oestrogen oht organelle overlap pf rationale remarkable remodelling reorganisation reprogrammed rhof transcriptome uncovered unexpectedly
Tagcloud (Intersection) ?