ITGA7 and MYOC

Number of citations of the paper that reports this interaction (PMID 16289162)
20

Data Source:
HPRD (two hybrid)

		ITGA7	MYOC
Gene Name		integrin, alpha 7	myocilin, trabecular meshwork inducible glucocorticoid response
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Muscle Tendon Junction Cell Surface Neuromuscular Junction Integrin Alpha7-beta1 Complex Sarcolemma	Proteinaceous Extracellular Matrix Extracellular Space Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Cilium Cytoplasmic Membrane-bounded Vesicle Extracellular Matrix Cytoplasmic Vesicle Node Of Ranvier Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Laminin Binding Metal Ion Binding Protein Heterodimerization Activity	Fibronectin Binding Frizzled Binding Protein Binding Receptor Tyrosine Kinase Binding Myosin Light Chain Binding
	Biological Process	Cell-matrix Adhesion Integrin-mediated Signaling Pathway Muscle Organ Development Skeletal Muscle Tissue Development Regulation Of Cell Shape Cell Migration Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Blood Vessel Morphogenesis	Osteoblast Differentiation Negative Regulation Of Cell-matrix Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Skeletal Muscle Hypertrophy Myelination In Peripheral Nervous System Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Non-canonical Wnt Signaling Pathway Via JNK Cascade ERBB2-ERBB3 Signaling Pathway Regulation Of MAPK Cascade Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Bone Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Laminin interactions ECM proteoglycans Integrin cell surface interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CHRNA1 FHL2 FHL3 MYOC	40 interactors: A2M ACTA2 ACTB ACTG1 ALDOA ANXA2 C1QB CAP1 CD81 CKM CLIC1 COL1A2 COL3A1 ECE1 EEF1A1 ENO1 FBN1 FN1 FTL FUBP1 GAPDH GGTLC1 HAGH IGLL1 ITGA7 LAMA5 LGALS3 MAEA MYL2 NOTCH2 OLFM3 OLFML3 PKLR PKM RFC1 SERPINF1 TGFBR1 TIMP1 TKT TNFRSF1A
Entrez ID		3679	4653
HPRD ID		02761	03387
Ensembl ID		ENSG00000135424	ENSG00000034971
Uniprot IDs		J3KNV4 Q13683 Q4LE35	Q99972
PDB IDs
Enriched GO Terms of Interacting Partners?		Muscle Structure Development Skeletal Muscle Hypertrophy ERBB2-ERBB3 Signaling Pathway Osteoblast Differentiation Organ Development ERBB2 Signaling Pathway Atrial Cardiac Muscle Cell Development Skeletal Muscle Tissue Growth Muscle System Process Muscle Organ Development Ossification Non-canonical Wnt Signaling Pathway Via JNK Cascade System Development Striated Muscle Tissue Development Neuron Cellular Homeostasis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Muscle Tissue Development Clustering Of Voltage-gated Sodium Channels Skeletal Muscle Adaptation Positive Regulation Of Mitochondrial Depolarization Multicellular Organismal Development Negative Regulation Of Stress Fiber Assembly Anatomical Structure Development Neuronal Ion Channel Clustering Negative Regulation Of Actin Filament Bundle Assembly Heart Trabecula Formation Developmental Process Regulation Of Mitochondrial Depolarization Ventricular Cardiac Muscle Cell Development Negative Regulation Of Rho Protein Signal Transduction Neuromuscular Synaptic Transmission Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Muscle Cell Cellular Homeostasis Heart Trabecula Morphogenesis Muscle Hypertrophy Ventricular Cardiac Muscle Cell Differentiation Skeletal Muscle Contraction Neuron Maturation Neuronal Action Potential Non-canonical Wnt Signaling Pathway Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Membrane Depolarization Negative Regulation Of Cell-matrix Adhesion Androgen Receptor Signaling Pathway Musculoskeletal Movement Positive Regulation Of Stress Fiber Assembly Myelination In Peripheral Nervous System Regulation Of Focal Adhesion Assembly	Extracellular Matrix Organization Extracellular Structure Organization Platelet Activation Extracellular Matrix Disassembly Cell Activation Response To Wounding Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Cardiovascular System Development Collagen Fibril Organization System Development Developmental Process Blood Vessel Development Platelet Degranulation Multicellular Organismal Development Vasculature Development Glycolytic Process Organ Development Pyruvate Metabolic Process Pathogenesis Anatomical Structure Development Response To Stress Anatomical Structure Morphogenesis Monosaccharide Metabolic Process Carbohydrate Catabolic Process Locomotion Cell Development Glucose Metabolic Process Cell Differentiation Regulation Of Cellular Component Movement Vesicle-mediated Transport Response To Stimulus Movement Of Cell Or Subcellular Component Hexose Metabolic Process Immune System Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Skeletal System Development Platelet Aggregation Generation Of Precursor Metabolites And Energy Blood Vessel Morphogenesis Secretion Regulation Of Cell Motility Regulation Of Immune Response Organic Acid Metabolic Process Tissue Development Regulation Of Locomotion Cell Adhesion
Tagcloud ?			accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Difference) ?			accessible applicability atomic biomedically bladed broader continue deciphering detail differentiating distinctive divergent glaucoma glycerol hubs hydrophilic inherited mapped movements myocilin ocular olf olfactomedin onto overlapping propellers pursuit solved synonymous
Tagcloud (Intersection) ?