ITGA1 and TLN1

Number of citations of the paper that reports this interaction (PubMedID 11336656)
36

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		ITGA1	TLN1
Description		integrin subunit alpha 1	talin 1
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Perikaryon Basal Part Of Cell Extracellular Exosome	Ruffle Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Membrane Ruffle Membrane Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Signaling Receptor Binding Protein Binding Collagen Binding Phosphatase Activator Activity Protein Phosphatase Binding Signaling Receptor Activity Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion	Phosphatidylserine Binding Actin Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Neutrophil Chemotaxis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation Neuron Projection Morphogenesis Cell Chemotaxis Cell-cell Adhesion	Cell-cell Junction Assembly Cell-substrate Junction Assembly Cell Adhesion Integrin-mediated Signaling Pathway Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Integrin Activation Cortical Microtubule Organization Regulation Of Focal Adhesion Assembly Platelet Aggregation Cell-cell Adhesion
Pathways		Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen	Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Alzheimer's disease biomarkers ( 23419831) Apolipoprotein B levels ( 32203549) Attention deficit hyperactivity disorder ( 28809852) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 26708285) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 33339817 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1/FVC) ( 30804560 28166213) Metabolite levels ( 23823483) Myocardial infarction ( 26708285) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30578418 30224653) Red blood cell count ( 32888494) Response to platinum-based agents ( 22020760) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 33547301) Serum thyroid-stimulating hormone levels ( 25436638) Serum total protein levels ( 29403010) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969 29926116 30718926 32499647 30130595) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494)
Interacting Genes		10 interacting genes: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1	37 interacting genes: ABI1 ACTA1 ARHGAP31 AZIN2 CDK5 CEBPA DAG1 DOK1 EGFR ERBB2 FMO1 HSP90AA1 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP NYAP1 PIP5K1C PKD1 PTK2 PTK2B PXN RET SMURF1 SUMO2 TES TPTE TUBA1A VCL YWHAQ
Entrez ID		3672	7094
HPRD ID		01892	01726
Ensembl ID		ENSG00000213949	ENSG00000137076
Uniprot IDs		P56199	Q9Y490
PDB IDs		1PT6 1QC5 1QCY 2L8S 2M32 4A0Q 5HGJ	1SYQ 2MWN 4DJ9 6R9T
Enriched GO Terms of Interacting Partners?		Cell Differentiation Extracellular Matrix Basement Membrane Cell Adhesion Integrin Binding Lipid Tube Assembly Regulation Of Multicellular Organismal Development Cellular Developmental Process Negative Regulation Of Cardiac Muscle Cell Contraction Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Regulation Of Cell Adhesion Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Collagen Type VIII Trimer Anatomical Structure Morphogenesis Collagen Type XIII Trimer Myoblast Fate Specification Integrin Alpha6-beta1 Complex Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Integrin Alpha8-beta1 Complex Integrin Alpha1-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alphav-beta1 Complex Integrin Alpha11-beta1 Complex Cardiac Cell Fate Specification Integrin Alpha3-beta1 Complex Integrin Alpha9-beta1 Complex Growth Plate Cartilage Chondrocyte Morphogenesis Negative Regulation Of Interleukin-4-mediated Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Protease Binding Developmental Process Ubiquitin Binding Lipophagy Cell-matrix Adhesion Ruffle Integrin-mediated Signaling Pathway Integrin Alpha4-beta1 Complex Integrin Alpha2-beta1 Complex Ruffle Membrane Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Laminin-1 Complex Laminin-3 Complex	Focal Adhesion Cell-matrix Adhesion Cell-substrate Adhesion Integrin Complex Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Cell Motility Cell Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Signal Transduction Cell Adhesion Mediated By Integrin Lamellipodium Enzyme-linked Receptor Protein Signaling Pathway Filopodium Virus Receptor Activity Regulation Of Protein Metabolic Process Cell Surface Anchoring Junction Cell Projection Symbiont Entry Into Host Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Exosome Signal Complex Assembly Developmental Process Integrin Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Protein Metabolic Process Heterotypic Cell-cell Adhesion Biological Process Involved In Interaction With Host Neuron Projection Morphogenesis Protein Phosphatase Binding Vinculin Binding Cell Projection Morphogenesis Cell Projection Organization Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Wound Healing, Spreading Of Epidermal Cells Integrin Alpha1-beta1 Complex Regulation Of Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?